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Entry version 100 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

ABC-type multidrug transporter with fused ATPase and permease domains

Gene

Bd2583

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi417 – 424ATPPROSITE-ProRule annotation8
Nucleotide bindingi1031 – 1038ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BBAC264462:BD_RS11795-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.37, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ABC-type multidrug transporter with fused ATPase and permease domainsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Bd2583Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri264462 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaOligoflexiaBdellovibrionalesBdellovibrionaceaeBdellovibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 89HelicalSequence analysisAdd BLAST18
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23
Transmembranei182 – 205HelicalSequence analysisAdd BLAST24
Transmembranei211 – 229HelicalSequence analysisAdd BLAST19
Transmembranei292 – 316HelicalSequence analysisAdd BLAST25
Transmembranei678 – 697HelicalSequence analysisAdd BLAST20
Transmembranei717 – 739HelicalSequence analysisAdd BLAST23
Transmembranei812 – 830HelicalSequence analysisAdd BLAST19
Transmembranei904 – 927HelicalSequence analysisAdd BLAST24
Transmembranei933 – 951HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
264462.Bd2583

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 351ABC transmembrane type-1InterPro annotationAdd BLAST279
Domaini383 – 611ABC transporterInterPro annotationAdd BLAST229
Domaini678 – 959ABC transmembrane type-1InterPro annotationAdd BLAST282
Domaini999 – 1228ABC transporterInterPro annotationAdd BLAST230

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1132, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_27_1_7

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFMLPMT

Database of Orthologous Groups

More...
OrthoDBi
643917at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6MK31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFFRRLLFT DVTPLVKLAK TKNIEESDLL ALPQELNPQH IKVDMQEISW
60 70 80 90 100
KSPRALLFSL IRALRDFTRP AYIWYLASSV LALLSPVFVN RFIGTISAGV
110 120 130 140 150
TAETLPTALI YGVALGLCGF LSGLCMQHYF FNSLKAYQVT TNILNERLFK
160 170 180 190 200
HSLKLSQKSR QKNQVGDIVN HMSSDSDNVS DFPMVFGDLI SASFLIIGVV
210 220 230 240 250
AMLFYYIGWS ALAALAVLFI LAPLTNYVAK KFTHLDEEMM EHRDRRVTLM
260 270 280 290 300
TQAMNAIRVV KYFAWEKSVA KEVTEVREKE LTSRRRLAKA EVVSSLGYLA
310 320 330 340 350
VSTLVLFVAL AVHAWRGEKL DAAVIFTCIS LFGLLEGPFG DLSRLISRAT
360 370 380 390 400
NAKVGARRIL DYLNEDEVEI STEERTDGAA VGLQMQHFSL RHDGAVSDVL
410 420 430 440 450
HDVNVHVPAG SSLAIVGPVG AGKSSLLMSL LGEVAPREGS LQFVPEMPGR
460 470 480 490 500
PRMAYVPQEA YIVNTSLLEN LQFGEEVSKE ELRRALHNSC LSRDLKEWSG
510 520 530 540 550
GLRTEIGEKG VNLSGGQKQR VALARAFLRK PQIVLLDDPL SAVDADTENL
560 570 580 590 600
LCERLIFGAW KDVTRIVVTH RLEHLAQFDQ VIYIQHGRVQ GQGTFSELVK
610 620 630 640 650
TCAPFAEFYK EHGKTQGEGH EVRPAETAQE AASINTELEA KTTRVTEDED
660 670 680 690 700
REVGAVKGSV YWDYISSLGG DGKFTKPLIL ATLLLGATAA TLLPLAQKAW
710 720 730 740 750
LSYYSGHQTE WVALTAIGIY GLIGVLVLVG SLLNHLFWLD RGIRAGKNMH
760 770 780 790 800
DKMLKSVLSS PVRFFDSTPV GRIIQRFSRD VESVDVYLQW SFDSAVHCAL
810 820 830 840 850
QVIVSIVLIL GLMPLMVFVI APVMALYYVL QRDYRRPARE VKRFDSVARS
860 870 880 890 900
PRYAHFKESL QGLVVIRSFN KGPWFMQNFY AKLSHSNRMF YSHVMINRWF
910 920 930 940 950
SSRIPLVGGL ISMATAVGVS LSAYYGVMDA GTAGLVTLYS LSFWGFLNWG
960 970 980 990 1000
VRIFADIESR MTSIERLKFF SNLPGEVSVL KPLPEPLRPT WPEFGEISVE
1010 1020 1030 1040 1050
GLKVRYASHL PQVLKGITFK VEAGSRVGII GRTGSGKSTF FQSLFRFIEA
1060 1070 1080 1090 1100
EEGSISIDGV NTASVPLEKL RRSLAIIPQD PTLFMGTIRN NLDRYNEYSD
1110 1120 1130 1140 1150
DEVMGALKHA SMWDYVQSLP DGMNSAVSEG GLNLSQGQRQ LLCLARALLT
1160 1170 1180 1190 1200
KARVIVMDEA TASVDVQTDA LLQKVIRTSF AGVTMLIIAH RLGTIADCDQ
1210 1220
IVEISAGEVK SIRRPTEFSQ EEIEESLV
Length:1,228
Mass (Da):136,603
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFD9468FE20A1800
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX842653 Genomic DNA Translation: CAE80378.1

NCBI Reference Sequences

More...
RefSeqi
WP_011164981.1, NC_005363.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAE80378; CAE80378; Bd2583

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bba:Bd2583

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842653 Genomic DNA Translation: CAE80378.1
RefSeqiWP_011164981.1, NC_005363.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi264462.Bd2583

Protein family/group databases

TCDBi3.A.1.208.37, the atp-binding cassette (abc) superfamily

Genome annotation databases

EnsemblBacteriaiCAE80378; CAE80378; Bd2583
KEGGibba:Bd2583

Phylogenomic databases

eggNOGiCOG1132, Bacteria
HOGENOMiCLU_000604_27_1_7
OMAiLFMLPMT
OrthoDBi643917at2

Enzyme and pathway databases

BioCyciBBAC264462:BD_RS11795-MONOMER

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MK31_BDEBA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MK31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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