Daxx

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• androgen receptor binding Source: Ensembl
• DNA-binding transcription factor inhibitor activity Source: Ensembl
• histone binding Source: Ensembl
• p53 binding Source: Ensembl
• protein kinase activator activity Source: Ensembl
• protein kinase binding Source: Ensembl
• protein N-terminus binding Source: Ensembl
• sumo-dependent protein binding Source: Ensembl
• transcription coactivator activity Source: Ensembl
• transcription corepressor activity Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• androgen receptor signaling pathway Source: Ensembl
• apoptotic process Source: UniProtKB-KW
• cellular response to cadmium ion Source: Ensembl
• cellular response to copper ion Source: Ensembl
• cellular response to diamide Source: Ensembl
• cellular response to heat Source: Ensembl
• cellular response to sodium arsenite Source: Ensembl
• cellular response to unfolded protein Source: Ensembl
• chromatin remodeling Source: Ensembl
• negative regulation of transcription, DNA-templated Source: Ensembl
• nucleosome assembly Source: Ensembl
• positive regulation of neuron death Source: Ensembl
• regulation of protein ubiquitination Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• androgen receptor binding Source: Ensembl
• histone binding Source: Ensembl
• p53 binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein N-terminus binding Source: Ensembl
• sumo-dependent protein binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MATDDSIIVL DDDDEDEAAA QPGPSNPASN PVSPGPEASG PSESHGDGGS 
        60         70         80         90        100
SNSGSRKCYK LENEKLFEEF LELCKMQTSD HPEVVPFLHK LQQRAQSAFL 
       110        120        130        140        150
ASAEFRNILS RVLSRSRNRP AKLYVYINEL CTVLKAHSIK KKLNLAPAAS 
       160        170        180        190        200
AESSGDNPPT DPPSDLTNTE TTASEASRTR GSRRQIQRLE QLLALYVAEI 
       210        220        230        240        250
QRLQEKELDL SELDDPDSSY LQEARLKRKL IRLFGRLCEL KDCSSLTGRV 
       260        270        280        290        300
IEQRIPYRGT RYPEVNRRIE RLINKPGPDT FPDYGDVLRA VEKAATRHSL 
       310        320        330        340        350
GLPRQQLQLL AQDAFRDVGV RLQERRHLDL IYNFGCHLTD DYRPGVDPAL 
       360        370        380        390        400
TDPTLARRLR ENRTLAMSRL DEVISKYAMM QDKSEEGERQ KRRARLLATS 
       410        420        430        440        450
QSSDLPKASS DSGEGPSGVA SQEDPTTPKA ETEDEEDDEE SDDEEEEEEE 
       460        470        480        490        500
EEEEATEDED EDLEQLQEDQ DDEEEEEGDN EDDKSPTSPS PIFRRRNSAP 
       510        520        530        540        550
TEGLRSPEEQ QERGLTGTPA SPLEASPGLP STDAESSGEQ LQERLLAGES 
       560        570        580        590        600
PVSQLSELDM EALPEETIPS PEERGISSSR RKSDSSLPTI LENGAAMVTS 
       610        620        630        640        650
TSFNGRVSSH PCRDASPPSK RFRKEKKQLG PGPLENSYVK KQTMAQQDSG 
       660        670        680        690        700
WKISVLSTPS SPLASVGPVA DSSTRVDSPS HELVTSSLCN PSPSLILQTP 
       710        720        730
QSQSPRPCIY KTSVATQCDP EEIIVLSDSD                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ