RT1 class I, A1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-2-microglobulin binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model."
    Behrens D., Lange K., Fried A., Yoo-Ott K.A., Richter K., Fandrich F., Kronke M., Zavazava N.
    Transplantation 72:1974-1982(2001) [PubMed] [Europe PMC] [Abstract]
• peptide binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Peptide specificity of RT1-A1(c), an inhibitory rat major histocompatibility complex class I natural killer cell ligand."
    Stevens J., Jones R.C., Bordoli R.S., Trowsdale J., Gaskell S.J., Butcher G.W., Joly E.
    J Biol Chem 275:29217-29224(2000) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Expression of the rat MHC class I gene in the human B lymphoblastoid cell line Hmy 2 CIR."
    Salgar S.K., Kunz H.W., Gill T.J.
    Eur J Immunogenet 22:479-483(1995) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• immune response Source: InterPro
• negative regulation of natural killer cell mediated cytotoxicity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Self-MHC class Ia (RT1-A(n)) protects cells co-expressing the activatory allogeneic MHC class Ib molecule (RT1-E(u)) from NK lysis."
    Backman-Petersson E., Butcher G.W., Hedlund G.
    Int Immunol 12:843-850(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell mediated cytotoxicity Source: RGDInferred from direct assayⁱ
  • "Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model."
    Behrens D., Lange K., Fried A., Yoo-Ott K.A., Richter K., Fandrich F., Kronke M., Zavazava N.
    Transplantation 72:1974-1982(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tolerance induction to nonself antigen Source: RGDInferred from mutant phenotypeⁱ
  • "Recombinant dimeric MHC antigens protect cardiac allografts from rejection and visualize alloreactive T cells."
    Fried A., Berg M., Sharma B., Bonde S., Zavazava N.
    J Leukoc Biol 78:595-604(2005) [PubMed] [Europe PMC] [Abstract]
• T cell tolerance induction Source: RGDInferred from mutant phenotypeⁱ
  • "Recombinant dimeric MHC antigens protect cardiac allografts from rejection and visualize alloreactive T cells."
    Fried A., Berg M., Sharma B., Bonde S., Zavazava N.
    J Leukoc Biol 78:595-604(2005) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• beta-2-microglobulin binding Source: RGDInferred from physical interactionⁱ
  • "Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model."
    Behrens D., Lange K., Fried A., Yoo-Ott K.A., Richter K., Fandrich F., Kronke M., Zavazava N.
    Transplantation 72:1974-1982(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGAMAPRTLL LILAAALAPT QTRAGSHSMR YFDIAVSRPG LGEPRFIIVG 
        60         70         80         90        100
YVDDTEFVRF DSDAEKPRYE PRAPWMEPEG PEYWEEQTRR AKEGEQTFRV 
       110        120        130        140        150
NLRTALHYYN QSEDRSHTIQ RLSGCDVGSD GRLLRGYEQY AYDGRDYIAL 
       160        170        180        190        200
NEDLKTWTAA DFAARISRNK WDQAGVAERL RAYLEGECVE WLRRYLELGK 
       210        220        230        240        250
ETLLRSDPPK AHVTLHPRPE GDVTLRCWAL GFYPADITLT WQLNGEDLTQ 
       260        270        280        290        300
DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVEHEGL PEPLSQRWEP 
       310        320        330        340        350
PPSTDSNMET TVIYVVLGAV AIIAAVIIGA VVTVVRKRRR NTGGKGVYTP 
       360 
APGTDSSQSS DVSLPDCKA                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ