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UniProtKB - Q6MGA6 (Q6MGA6_RAT)
Protein
Proteasome subunit beta
Gene
Psmb9
Organism
Rattus norvegicus (Rat)
Status
Functioni
Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
UniRule annotationCatalytic activityi
- Cleavage of peptide bonds with very broad specificity.ARBA annotation EC:3.4.25.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 21 | NucleophileUniRule annotation | 1 |
GO - Molecular functioni
- threonine-type endopeptidase activity Source: InterPro
GO - Biological processi
- immune system process Source: UniProtKB-KW
- proteolysis involved in cellular protein catabolic process Source: InterPro
Keywordsi
Biological process | ImmunityARBA annotation |
Protein family/group databases
MEROPSi | T01.013 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit betaUniRule annotation |
Gene namesi | Name:Psmb9Imported Synonyms:Arrb2-psImported, Hla-dmaImported, Hla-dmbImported, RT1-BaImported, RT1-BbImported, RT1-DaImported, RT1-Db1Imported, RT1-Db2Imported, RT1-DObImported, Tap1Imported, Tap2Imported, TesbImported ORF Names:rCG_60725Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3427, Psmb9 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- proteasome core complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation, ProteasomeUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000000459, Expressed in thymus and 22 other tissues |
Interactioni
Subunit structurei
Component of the proteasome complex.
UniRule annotationStructurei
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase T1B family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000159897 |
HOGENOMi | CLU_035750_5_2_1 |
OMAi | GWDHREG |
OrthoDBi | 1172133at2759 |
TreeFami | TF106221 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR034383, Proteasome_beta9 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF50, PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6MGA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQAGAPTAG SFRTGEVHTG TTIMAVEFDG GVVVGSDSRV SAGAAVVNRV
60 70 80 90 100
FDKLSPLHQR IYCALSGSAA DAQAIADMAA YQLELHGLEL EEPPLVLAAA
110 120 130 140 150
NIVKNISYKY REDLLAHLMV AGWDQREGGQ VYGTMGGMLI RQPFAIGGSG
160 170 180 190 200
STYIYGYVDA AYKPGMTPEE CRRFTTDAIT LAMNRDGSSG GVIYLVTITA
210
DGVDHRVILG DELPKFYDE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP28077 | PSB9_RAT | Proteasome subunit beta type-9 | Psmb9 Lmp2, Ring12 | 219 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098547 Genomic DNA No translation available. BC091161 mRNA Translation: AAH91161.1 KC222887 mRNA Translation: AGV38984.1 KC222889 mRNA Translation: AGV38986.1 BX883043 Genomic DNA Translation: CAE83940.1 CH473988 Genomic DNA Translation: EDL96811.1 |
RefSeqi | NP_036840.2, NM_012708.2 |
Genome annotation databases
Ensembli | ENSRNOT00000000532; ENSRNOP00000000532; ENSRNOG00000000459 |
GeneIDi | 24967 |
KEGGi | rno:24967 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098547 Genomic DNA No translation available. BC091161 mRNA Translation: AAH91161.1 KC222887 mRNA Translation: AGV38984.1 KC222889 mRNA Translation: AGV38986.1 BX883043 Genomic DNA Translation: CAE83940.1 CH473988 Genomic DNA Translation: EDL96811.1 |
RefSeqi | NP_036840.2, NM_012708.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | T01.013 |
Genome annotation databases
Ensembli | ENSRNOT00000000532; ENSRNOP00000000532; ENSRNOG00000000459 |
GeneIDi | 24967 |
KEGGi | rno:24967 |
Organism-specific databases
CTDi | 5698 |
RGDi | 3427, Psmb9 |
Phylogenomic databases
GeneTreei | ENSGT00940000159897 |
HOGENOMi | CLU_035750_5_2_1 |
OMAi | GWDHREG |
OrthoDBi | 1172133at2759 |
TreeFami | TF106221 |
Gene expression databases
Bgeei | ENSRNOG00000000459, Expressed in thymus and 22 other tissues |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR000243, Pept_T1A_subB IPR034383, Proteasome_beta9 IPR016050, Proteasome_bsu_CS IPR001353, Proteasome_sua/b IPR023333, Proteasome_suB-type |
PANTHERi | PTHR11599:SF50, PTHR11599:SF50, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit |
PRINTSi | PR00141, PROTEASOME |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00854, PROTEASOME_BETA_1, 1 hit PS51476, PROTEASOME_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6MGA6_RAT | |
Accessioni | Q6MGA6Primary (citable) accession number: Q6MGA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | January 19, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |