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Protein
Submitted name:

MHC class II antigen

Gene

RT1-Ba

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-RNO-202424 Downstream TCR signaling
R-RNO-202427 Phosphorylation of CD3 and TCR zeta chains
R-RNO-202430 Translocation of ZAP-70 to Immunological synapse
R-RNO-202433 Generation of second messenger molecules
R-RNO-2132295 MHC class II antigen presentation
R-RNO-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Submitted name:
RCG60724, isoform CRA_aImported
Submitted name:
RT1 class II, B alphaImported
Submitted name:
RT1 class II, locus BaImported
Submitted name:
RT1-BaImported
Submitted name:
Rano class II histocompatibility antigen, B alpha chainImported
Gene namesi
Name:RT1-BaImported
Synonyms:Arrb2-psImported, BA1Imported, Hla-dmaImported, Hla-dmbImported, Psmb9Imported, RT1-BbImported, RT1-DaImported, RT1-Db1Imported, RT1-Db2Imported, RT1-DObImported, Tap1Imported, Tap2Imported, TesbImported
ORF Names:rCG_60724Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1595867 RT1-Ba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei222 – 240HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501529857724 – 255Sequence analysisAdd BLAST232

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000000451 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000523

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 193Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IZMF Eukaryota
ENOG410YHX9 LUCA
GeneTreeiENSGT00900000140882
HOVERGENiHBG006862
KOiK06752
OMAiCFDSSDT
OrthoDBiEOG091G0IC9
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q6MGA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLSRALILG VLALTTMLSP CGGQDDIEAD HVAAYGINMY QYYESRGQYT
60 70 80 90 100
HEFDGDEEFY VDLDKKETIW RIPEFGQLTS FDPQGGLQEI ATAKYNLEIL
110 120 130 140 150
MKSNSTPATN KVPEATVFSK SPVLLGQPNT LICFVDNIFP PAINITWLRN
160 170 180 190 200
SKPVTEGTFE TSFLSNPDHS FHKMAYLTFI PSNDDIYDCK VEHWGLDEPV
210 220 230 240 250
LKHWEPEIPA PMSELTETVV CALGLSVGLV GIVVGTIFII QGLRSGGPSR

HPGPL
Length:255
Mass (Da):28,237
Last modified:July 5, 2004 - v1
Checksum:iC1F7D2870DEA39E4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P20037HA2B_RAT
Rano class II histocompatibility an...
RT1-Ba
256Annotation score:
A0A0G2JY95A0A0G2JY95_RAT
Rano class II histocompatibility an...
RT1-Ba
68Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072809 Genomic DNA No translation available.
BC086448 mRNA Translation: AAH86448.1
AY626197 mRNA Translation: AAV40626.1
KC222945 mRNA Translation: AGV39042.1
BX883043 Genomic DNA Translation: CAE83946.1
CH473988 Genomic DNA Translation: EDL96801.1
RefSeqiNP_001008831.1, NM_001008831.3
UniGeneiRn.25717

Genome annotation databases

EnsembliENSRNOT00000000523; ENSRNOP00000000523; ENSRNOG00000000451
GeneIDi309621
KEGGirno:309621

Similar proteinsi

Entry informationi

Entry nameiQ6MGA0_RAT
AccessioniPrimary (citable) accession number: Q6MGA0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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