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Entry version 147 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Notch homolog 4, [Drosophila]

Gene

Notch4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi452Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi455Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi472Calcium 2UniRule annotation1
Metal bindingi475Calcium 2UniRule annotation1
Metal bindingi489Calcium 2UniRule annotation1
Metal bindingi513Calcium 3UniRule annotation1
Metal bindingi527Calcium 3UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation, ReceptorARBA annotation
Biological processDifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1912420, Pre-NOTCH Processing in Golgi
R-RNO-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-RNO-9604323, Negative regulation of NOTCH4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Notch homolog 4, [Drosophila]Imported
Submitted name:
Notch homolog 4, isoform CRA_bImported
Submitted name:
Notch receptor 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Notch4Imported
Synonyms:AgerImported, Btnl6Imported, Cyp21a1-psImported, Ng5Imported, Rnf5Imported, Stk19-psImported, TnxImported
ORF Names:rCG_38227Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
1303282, Notch4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1403 – 1421HelicalSequence analysisAdd BLAST19
Transmembranei1441 – 1464HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501410644721 – 1961Sequence analysisAdd BLAST1941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 59PROSITE-ProRule annotation
Disulfide bondi102 ↔ 111PROSITE-ProRule annotation
Disulfide bondi142 ↔ 151PROSITE-ProRule annotation
Disulfide bondi179 ↔ 188PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi340 ↔ 349PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi398 ↔ 415PROSITE-ProRule annotation
Disulfide bondi417 ↔ 426PROSITE-ProRule annotation
Disulfide bondi433 ↔ 449UniRule annotation
Disulfide bondi443 ↔ 458UniRule annotation
Disulfide bondi460 ↔ 469UniRule annotation
Disulfide bondi476 ↔ 487UniRule annotation
Disulfide bondi481 ↔ 496UniRule annotation
Disulfide bondi498 ↔ 507UniRule annotation
Disulfide bondi514 ↔ 525UniRule annotation
Disulfide bondi519 ↔ 534UniRule annotation
Disulfide bondi536 ↔ 545UniRule annotation
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Disulfide bondi612 ↔ 621PROSITE-ProRule annotation
Disulfide bondi714 ↔ 723PROSITE-ProRule annotation
Disulfide bondi752 ↔ 761PROSITE-ProRule annotation
Disulfide bondi790 ↔ 799PROSITE-ProRule annotation
Disulfide bondi829 ↔ 838PROSITE-ProRule annotation
Disulfide bondi867 ↔ 876PROSITE-ProRule annotation
Disulfide bondi893 ↔ 903PROSITE-ProRule annotation
Disulfide bondi914 ↔ 923PROSITE-ProRule annotation
Disulfide bondi952 ↔ 961PROSITE-ProRule annotation
Disulfide bondi990 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1030 ↔ 1039PROSITE-ProRule annotation
Disulfide bondi1071 ↔ 1080PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1121PROSITE-ProRule annotation
Disulfide bondi1157 ↔ 1166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000442, Expressed in heart and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6MG89, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000000513

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 60EGF-likeInterPro annotationAdd BLAST40
Domaini61 – 112EGF-likeInterPro annotationAdd BLAST52
Domaini115 – 152EGF-likeInterPro annotationAdd BLAST38
Domaini153 – 189EGF-likeInterPro annotationAdd BLAST37
Domaini191 – 229EGF-likeInterPro annotationAdd BLAST39
Domaini231 – 271EGF-likeInterPro annotationAdd BLAST41
Domaini273 – 309EGF-likeInterPro annotationAdd BLAST37
Domaini311 – 350EGF-likeInterPro annotationAdd BLAST40
Domaini352 – 388EGF-likeInterPro annotationAdd BLAST37
Domaini389 – 427EGF-likeInterPro annotationAdd BLAST39
Domaini429 – 470EGF-likeInterPro annotationAdd BLAST42
Domaini472 – 508EGF-likeInterPro annotationAdd BLAST37
Domaini510 – 546EGF-likeInterPro annotationAdd BLAST37
Domaini548 – 584EGF-likeInterPro annotationAdd BLAST37
Domaini586 – 622EGF-likeInterPro annotationAdd BLAST37
Domaini688 – 724EGF-likeInterPro annotationAdd BLAST37
Domaini726 – 762EGF-likeInterPro annotationAdd BLAST37
Domaini764 – 800EGF-likeInterPro annotationAdd BLAST37
Domaini803 – 839EGF-likeInterPro annotationAdd BLAST37
Domaini841 – 877EGF-likeInterPro annotationAdd BLAST37
Domaini889 – 924EGF-likeInterPro annotationAdd BLAST36
Domaini926 – 962EGF-likeInterPro annotationAdd BLAST37
Domaini964 – 1000EGF-likeInterPro annotationAdd BLAST37
Domaini1002 – 1040EGF-likeInterPro annotationAdd BLAST39
Domaini1042 – 1081EGF-likeInterPro annotationAdd BLAST40
Domaini1083 – 1122EGF-likeInterPro annotationAdd BLAST40
Domaini1126 – 1167EGF-likeInterPro annotationAdd BLAST42
Domaini1166 – 1209LNRInterPro annotationAdd BLAST44
Domaini1210 – 1241LNRInterPro annotationAdd BLAST32
Domaini1247 – 1287LNRInterPro annotationAdd BLAST41
Domaini1578 – 1815ANK_REP_REGIONInterPro annotationAdd BLAST238
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1625 – 1657ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1658 – 1679ANKPROSITE-ProRule annotationAdd BLAST22
Repeati1692 – 1724ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1725 – 1757ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1758 – 1790ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1342 – 1371DisorderedSequence analysisAdd BLAST30
Regioni1874 – 1904DisorderedSequence analysisAdd BLAST31
Regioni1922 – 1961DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1353 – 1370PolarSequence analysisAdd BLAST18
Compositional biasi1890 – 1904PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000576_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWTGWDC

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 17 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01987, NOTCH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 28 hits
SM00179, EGF_CA, 21 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 3 hits
SSF90193, SSF90193, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 10 hits
PS00022, EGF_1, 27 hits
PS01186, EGF_2, 20 hits
PS50026, EGF_3, 27 hits
PS01187, EGF_CA, 3 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6MG89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC
60 70 80 90 100
APGFLGETCQ FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC
110 120 130 140 150
TCPSGFTGDR CQSPLEELCP PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ
160 170 180 190 200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP TGFEGHICER DVNECFLEPG
210 220 230 240 250
PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC LNGGTCQLVP
260 270 280 290 300
EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP
310 320 330 340 350
KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD
360 370 380 390 400
ENLDDCAAAT CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV
410 420 430 440 450
NAQCSTNPLT GSTLCICQPG YSGPTCHQDL DECQMAQQGP SPCEHGGSCI
460 470 480 490 500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFQCLCPP
510 520 530 540 550
GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF TGARCEKDMD
560 570 580 590 600
ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS
610 620 630 640 650
CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD
660 670 680 690 700
GSPGCVPAED DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG
710 720 730 740 750
GTCHPQPSGY NCSCLAGYTG LTCSEEITAC HSGPCLNGGS CSIHPEGYSC
760 770 780 790 800
TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM SKPGTFFCHC ATGFQGLHCE
810 820 830 840 850
KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC
860 870 880 890 900
PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG
910 920 930 940 950
GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC
960 970 980 990 1000
QCAPGYEGQN CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE
1010 1020 1030 1040 1050
GDVDECLDRP CHPSGTASCH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP
1060 1070 1080 1090 1100
CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC SRKAPACGNH HCHNGGLCLP
1110 1120 1130 1140 1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG SCTETPGLGN
1160 1170 1180 1190 1200
PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA
1260 1270 1280 1290 1300
YDQYCRDHFH NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS
1310 1320 1330 1340 1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGT
1360 1370 1380 1390 1400
RDSSSWERQA PHTQTPGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPRD
1410 1420 1430 1440 1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR LPWPILCSPV
1460 1470 1480 1490 1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL
1510 1520 1530 1540 1550
GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC
1560 1570 1580 1590 1600
EGLPQAVMLT PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL
1610 1620 1630 1640 1650
GLGNPEPWEP LLDRGACPQA HTVGTGETPL HLAARFSRPT AARRLLEAGA
1660 1670 1680 1690 1700
NPNQPDRAGR TPLHTAVAAD AREVCQLLLA SRQTAVDART DDGTTPLMLA
1710 1720 1730 1740 1750
ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR AARCLLQTGA
1760 1770 1780 1790 1800
DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR
1810 1820 1830 1840 1850
QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG
1860 1870 1880 1890 1900
ACLQARTWSV DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA
1910 1920 1930 1940 1950
RVSQDDWPRD WVALEACGSA CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE
1960
VPLNSGGRNQ N
Length:1,961
Mass (Da):206,076
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B1034E29EE07A3C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07044388 Genomic DNA No translation available.
BX883044 Genomic DNA Translation: CAE83957.1
CH474121 Genomic DNA Translation: EDL83377.1

NCBI Reference Sequences

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RefSeqi
NP_001002827.1, NM_001002827.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442

Database of genes from NCBI RefSeq genomes

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GeneIDi
406162

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:406162

UCSC genome browser

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UCSCi
RGD:1303282, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044388 Genomic DNA No translation available.
BX883044 Genomic DNA Translation: CAE83957.1
CH474121 Genomic DNA Translation: EDL83377.1
RefSeqiNP_001002827.1, NM_001002827.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6MG89, 3 interactors
STRINGi10116.ENSRNOP00000000513

Genome annotation databases

EnsembliENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442
GeneIDi406162
KEGGirno:406162
UCSCiRGD:1303282, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4855
RGDi1303282, Notch4

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000163287
HOGENOMiCLU_000576_0_0_1
OMAiAWTGWDC
OrthoDBi7525at2759
TreeFamiTF351641

Enzyme and pathway databases

ReactomeiR-RNO-1912420, Pre-NOTCH Processing in Golgi
R-RNO-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-RNO-9604323, Negative regulation of NOTCH4 signaling

Miscellaneous databases

Protein Ontology

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PROi
PR:Q6MG89

Gene expression databases

BgeeiENSRNOG00000000442, Expressed in heart and 19 other tissues

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 17 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 3 hits
PRINTSiPR01452, LNOTCHREPEAT
PR01987, NOTCH4
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 28 hits
SM00179, EGF_CA, 21 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 3 hits
SSF90193, SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 10 hits
PS00022, EGF_1, 27 hits
PS01186, EGF_2, 20 hits
PS50026, EGF_3, 27 hits
PS01187, EGF_CA, 3 hits
PS50258, LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MG89_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MG89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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