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Entry version 108 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of pre-mRNA splicing.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell differentiation Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prrc2a
Synonyms:Bat2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
1303025, Prrc2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648321 – 2161Protein PRRC2AAdd BLAST2161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei35N6-acetyllysineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei272Asymmetric dimethylarginineBy similarity1
Modified residuei296Omega-N-methylarginineBy similarity1
Modified residuei342PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei760PhosphoserineBy similarity1
Modified residuei762PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei808PhosphothreonineBy similarity1
Modified residuei809PhosphoserineCombined sources1
Modified residuei908Omega-N-methylarginineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei1000PhosphothreonineBy similarity1
Modified residuei1007PhosphoserineCombined sources1
Modified residuei1069Omega-N-methylarginineBy similarity1
Modified residuei1086PhosphothreonineBy similarity1
Modified residuei1088PhosphoserineCombined sources1
Modified residuei1092PhosphoserineBy similarity1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1097PhosphotyrosineBy similarity1
Modified residuei1109PhosphoserineBy similarity1
Modified residuei1113PhosphoserineCombined sources1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1150PhosphoserineCombined sources1
Modified residuei1199N6-acetyllysineBy similarity1
Modified residuei1222PhosphoserineCombined sources1
Modified residuei1307PhosphoserineBy similarity1
Modified residuei1311PhosphoserineBy similarity1
Modified residuei1324PhosphothreonineBy similarity1
Modified residuei1326PhosphoserineBy similarity1
Modified residuei1329PhosphoserineBy similarity1
Modified residuei1348PhosphothreonineBy similarity1
Modified residuei1354PhosphothreonineBy similarity1
Modified residuei1385PhosphoserineBy similarity1
Modified residuei1387PhosphoserineBy similarity1
Modified residuei1406PhosphothreonineCombined sources1
Modified residuei1761PhosphoserineCombined sources1
Modified residuei2040PhosphoserineBy similarity1
Modified residuei2086PhosphoserineBy similarity1
Modified residuei2117PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6MG48

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6MG48

PRoteomics IDEntifications database

More...
PRIDEi
Q6MG48

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6MG48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6MG48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000852, Expressed in frontal cortex and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6MG48, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6MG48, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
254634, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6MG48, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6MG48

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 951-1Add BLAST55
Repeati98 – 1541-2Add BLAST57
Repeati281 – 3361-3Add BLAST56
Repeati337 – 4292-1Add BLAST93
Repeati487 – 5602-2Add BLAST74
Repeati1760 – 18151-4Add BLAST56
Repeati1920 – 19693-1Add BLAST50
Repeati1986 – 20353-2Add BLAST50
Repeati2061 – 21103-3Add BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni41 – 18154 X 57 AA type A repeatsAdd BLAST1775
Regioni49 – 716DisorderedSequence analysisAdd BLAST668
Regioni337 – 5602 X type B repeatsAdd BLAST224
Regioni738 – 1774DisorderedSequence analysisAdd BLAST1037
Regioni1806 – 1886DisorderedSequence analysisAdd BLAST81
Regioni1920 – 21103 X 50 AA type C repeatsAdd BLAST191
Regioni1948 – 1978DisorderedSequence analysisAdd BLAST31
Regioni2024 – 2049DisorderedSequence analysisAdd BLAST26
Regioni2065 – 2161DisorderedSequence analysisAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 121Polar residuesSequence analysisAdd BLAST36
Compositional biasi191 – 209Polar residuesSequence analysisAdd BLAST19
Compositional biasi212 – 231Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi237 – 277Pro residuesSequence analysisAdd BLAST41
Compositional biasi306 – 345Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi352 – 375Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi400 – 420Pro residuesSequence analysisAdd BLAST21
Compositional biasi437 – 453Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi462 – 502Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi508 – 542Pro residuesSequence analysisAdd BLAST35
Compositional biasi570 – 587Polar residuesSequence analysisAdd BLAST18
Compositional biasi593 – 614Pro residuesSequence analysisAdd BLAST22
Compositional biasi643 – 672Polar residuesSequence analysisAdd BLAST30
Compositional biasi673 – 716Pro residuesSequence analysisAdd BLAST44
Compositional biasi825 – 872Pro residuesSequence analysisAdd BLAST48
Compositional biasi943 – 968Pro residuesSequence analysisAdd BLAST26
Compositional biasi970 – 993Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1049 – 1068Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1089 – 1126Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1184 – 1208Pro residuesSequence analysisAdd BLAST25
Compositional biasi1235 – 1270Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi1306 – 1326Polar residuesSequence analysisAdd BLAST21
Compositional biasi1361 – 1375Polar residuesSequence analysisAdd BLAST15
Compositional biasi1445 – 1460Pro residuesSequence analysisAdd BLAST16
Compositional biasi1471 – 1491Polar residuesSequence analysisAdd BLAST21
Compositional biasi1496 – 1519Pro residuesSequence analysisAdd BLAST24
Compositional biasi1555 – 1570Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1642 – 1674Polar residuesSequence analysisAdd BLAST33
Compositional biasi1705 – 1728Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1811 – 1828Polar residuesSequence analysisAdd BLAST18
Compositional biasi1845 – 1879Polar residuesSequence analysisAdd BLAST35
Compositional biasi1955 – 1970Polar residuesSequence analysisAdd BLAST16
Compositional biasi2024 – 2040Pro residuesSequence analysisAdd BLAST17
Compositional biasi2070 – 2114Polar residuesSequence analysisAdd BLAST45
Compositional biasi2136 – 2152Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001247_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6MG48

Database of Orthologous Groups

More...
OrthoDBi
17901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6MG48

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038, PTHR14038, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07001, BAT2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6MG48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHKD SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE
410 420 430 440 450
PAAPPIPKPP PPPPHRGPVG NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ
460 470 480 490 500
RRKQSSSEIS LAVERARRRR EEEERRMQEE RRAACAEKLK RLDEKFGAPD
510 520 530 540 550
KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT PEKDPEEPAH
560 570 580 590 600
APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP
610 620 630 640 650
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ
660 670 680 690 700
QEQLLKQQQQ QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP
710 720 730 740 750
PKALYPGALG RPPPMPPMNF DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH
760 770 780 790 800
PSGLVPRERS DSGGSSSEPF ERHAPPLLRE RGTPPVDPKL AWVGDVFTTT
810 820 830 840 850
PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP GFPENGTPGP
860 870 880 890 900
PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP
910 920 930 940 950
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP
960 970 980 990 1000
RRAGPIKKPP PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET
1010 1020 1030 1040 1050
PAGGNLSPAP RLRRDYSYER VGPTSCRGRG RGEYFARGRG FRGTYGGRGR
1060 1070 1080 1090 1100
GARSREFRSY REFRGDDGRG GGSGGTNHPS APRGRTASET RSEGSEYEEI
1110 1120 1130 1140 1150
PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL APPQPGAPPS
1160 1170 1180 1190 1200
PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP
1210 1220 1230 1240 1250
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ
1260 1270 1280 1290 1300
QDKPPRFRRL KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP
1310 1320 1330 1340 1350
RRTAAKSPDL SNQNSDQANE EWETASESSD FASERRGDKE TPPAALITSK
1360 1370 1380 1390 1400
AVGTPGGNSG GAGPGISTMS RGDLSQRAKD LSKRSFSSQR PGMDRQNRRP
1410 1420 1430 1440 1450
GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL
1460 1470 1480 1490 1500
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK
1510 1520 1530 1540 1550
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS
1560 1570 1580 1590 1600
AGVNPFPPKR RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD
1610 1620 1630 1640 1650
SGTEALTPHI WNRLHTATSR KSYQPGSIEP WMEPLSPFED VAGTEMSQSD
1660 1670 1680 1690 1700
SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA EGPPRRPGGP SPLKAVPGES
1710 1720 1730 1740 1750
SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER SQRTDRGPEP
1760 1770 1780 1790 1800
GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR
1810 1820 1830 1840 1850
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ
1860 1870 1880 1890 1900
VSGGAPIDSQ LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA
1910 1920 1930 1940 1950
LKGQFLDFSA LQATELGKLP AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV
1960 1970 1980 1990 2000
RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA QQMLLPVVDS QLPVVNFGSL
2010 2020 2030 2040 2050
PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS PARPFPASLG
2060 2070 2080 2090 2100
RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST
2110 2120 2130 2140 2150
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR
2160
GEKEPGLPPP R
Length:2,161
Mass (Da):229,047
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8843EDDB4443C6AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRZ5A0A0U1RRZ5_RAT
Protein PRRC2A
Prrc2a
2,162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX883046 Genomic DNA Translation: CAE83998.1

NCBI Reference Sequences

More...
RefSeqi
NP_997627.1, NM_212462.2
XP_006256114.1, XM_006256052.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
294250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:294250

UCSC genome browser

More...
UCSCi
RGD:1303025, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA Translation: CAE83998.1
RefSeqiNP_997627.1, NM_212462.2
XP_006256114.1, XM_006256052.3

3D structure databases

SMRiQ6MG48
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi254634, 1 interactor
IntActiQ6MG48, 2 interactors
STRINGi10116.ENSRNOP00000001133

PTM databases

iPTMnetiQ6MG48
PhosphoSitePlusiQ6MG48

Proteomic databases

jPOSTiQ6MG48
PaxDbiQ6MG48
PRIDEiQ6MG48

Genome annotation databases

EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852
GeneIDi294250
KEGGirno:294250
UCSCiRGD:1303025, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7916
RGDi1303025, Prrc2a

Phylogenomic databases

eggNOGiKOG4817, Eukaryota
GeneTreeiENSGT00950000183161
HOGENOMiCLU_001247_1_0_1
InParanoidiQ6MG48
OrthoDBi17901at2759
PhylomeDBiQ6MG48

Miscellaneous databases

Protein Ontology

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PROi
PR:Q6MG48

Gene expression databases

BgeeiENSRNOG00000000852, Expressed in frontal cortex and 22 other tissues
ExpressionAtlasiQ6MG48, baseline and differential
GenevisibleiQ6MG48, RN

Family and domain databases

InterProiView protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2
PANTHERiPTHR14038, PTHR14038, 1 hit
PfamiView protein in Pfam
PF07001, BAT2_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRC2A_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MG48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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