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Entry version 102 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Error-prone DNA polymerase

Gene

dnaE2

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CORYNE:G18NG-10200-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Error-prone DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnaE2UniRule annotation
Ordered Locus Names:Cgl0638, cg0738
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001033781 – 1055Error-prone DNA polymeraseAdd BLAST1055

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6M7C6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
196627.cg0738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6M7C6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0587, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001600_4_0_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSWPMGF

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01902, DNApol_error_prone, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR023073, DNA_pol_error_prone
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha

The PANTHER Classification System

More...
PANTHERi
PTHR32294, PTHR32294, 1 hit
PTHR32294:SF4, PTHR32294:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89550, SSF89550, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6M7C6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPIIMEWNG GGSFNGRPLS WSKLERILSG KKVESLRPVL HEPDAQAPSS
60 70 80 90 100
AMQGEASVPF AELHATSSYN FLTGASDPSD VVVQAKKLGL VALSVMDRDG
110 120 130 140 150
FYGAVRFAEA AAEAGMHTVY GAELSLQEGV LTVLCKNPEG YKKLSHLISD
160 170 180 190 200
AKMATGEKGE VRYPPLPMVA EHAAGDWVVL AGFQWLDKID YVIDCFKPEN
210 220 230 240 250
IVLEFGSTMT PEDADRNEYL RRTQAKFQLR GILSTNPESA ARGSVRLAGA
260 270 280 290 300
KQALARKMPL ADAESELHPM GTTWMRSGDT LLKAHPDYAD LIATTVELAA
310 320 330 340 350
ECAFTLDLVA PNLPKWDTPG EHTEMSWLAH LVSTRIDTRY VGRSADIKAR
360 370 380 390 400
AATQIDYELG VIEKLGFPGY FLVVNDLVEF CRDSNILCQG RGSAANSAVC
410 420 430 440 450
FVLGITNAEP ISAGLLFERF LSPDRDGPPD IDIDIESGRR EEVIQYVYEK
460 470 480 490 500
YGRDNAAQVA NVITYRTKGA MRDAARALGY PQGAADAWAK GTSEPPDDVL
510 520 530 540 550
ELAAQFKGQP RHLGIHSGGM VICDRPIADV VPVEWARMDN RSVVQWDKDD
560 570 580 590 600
CATAGLVKFD LLGLGMLEAI HHMLDLVAEH RGKKINLWEL DLAEPEVYDM
610 620 630 640 650
LCKADAVGVF QVESRAQLST LPRLKPRTFF DLVVEVALIR PGPIQGGSVH
660 670 680 690 700
PYLRRRAGEE AITYDHPVLE KSLGKTLGIP LFQEQLMQVA VDAAGFSGGE
710 720 730 740 750
ADSLRRAMGS KRSPERMAAL RSRFFQGLKD TNGIVGETAE KLWNKIVAFA
760 770 780 790 800
AYGFPESHSQ SFASLVYFSA WFKYHYPAEF CVGLLRAQPM GFYSPQSLIS
810 820 830 840 850
DARRHGVSIL PITVNDSGVE ADAPNGAIRL GLNLVKGLGH DAAQRIEDNA
860 870 880 890 900
PFDSIPDLSR RADLNVAQVE ALARAGAVDC LGVGRRQALW QAGVAATEKP
910 920 930 940 950
GMLPGLSVIE APALPGMSAF ELMATNISAT GVTADYQPMA LIRERMEELG
960 970 980 990 1000
IVPADRLLEV EDGTRLRIAG IVTHRQRPQT ASGLTFLGME DETGLMNVMV
1010 1020 1030 1040 1050
SVGLWQRQRV LARNAKALII RGIVQNAQGV ATVVADRLEP LDMGEFLSRG

SRDFR
Length:1,055
Mass (Da):115,099
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91B4912894FEB6C2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB98031 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98031.1 Different initiation.
BX927149 Genomic DNA Translation: CAF19345.1

NCBI Reference Sequences

More...
RefSeqi
NP_599872.1, NC_003450.3
WP_011013785.1, NC_006958.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB98031; BAB98031; BAB98031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgb:cg0738
cgl:NCgl0611

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|196627.13.peg.624

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98031.1 Different initiation.
BX927149 Genomic DNA Translation: CAF19345.1
RefSeqiNP_599872.1, NC_003450.3
WP_011013785.1, NC_006958.1

3D structure databases

SMRiQ6M7C6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi196627.cg0738

Proteomic databases

PRIDEiQ6M7C6

Genome annotation databases

EnsemblBacteriaiBAB98031; BAB98031; BAB98031
KEGGicgb:cg0738
cgl:NCgl0611
PATRICifig|196627.13.peg.624

Phylogenomic databases

eggNOGiCOG0587, Bacteria
HOGENOMiCLU_001600_4_0_11
OMAiNSWPMGF

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10200-MONOMER

Family and domain databases

HAMAPiMF_01902, DNApol_error_prone, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR023073, DNA_pol_error_prone
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha
PANTHERiPTHR32294, PTHR32294, 1 hit
PTHR32294:SF4, PTHR32294:SF4, 1 hit
PfamiView protein in Pfam
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
SMARTiView protein in SMART
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF89550, SSF89550, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNAE2_CORGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6M7C6
Secondary accession number(s): Q8NSN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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