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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Activity regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:MMP0251
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241771 – 259Proteasome subunit alphaAdd BLAST259

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-59085N
IntActiQ6M0L9, 3 interactors
STRINGi267377.MMP0251

Structurei

3D structure databases

ProteinModelPortaliQ6M0L9
SMRiQ6M0L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00971 Archaea
COG0638 LUCA
HOGENOMiHOG000091085
KOiK03432
OMAiFQVEYAR
OrthoDBiPOG093Z086S

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6M0L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQMVPASGY DRAITIFSPE GRLYQVEYAR EAVRRGTTAV GIKCKDGVVL
60 70 80 90 100
AVDRRITSKL IDVSSIEKIF QIDDHIVAAT SGLVADARVL IDRARIEAQM
110 120 130 140 150
NRVSYGEAIT VEALAKKICD IKQAYTQHGG ARPFGLALLI TGIDRHSARL
160 170 180 190 200
FETDPSGALI EYKATAIGSG RPIAMEVLES KYDENMTVSE GMELALYALS
210 220 230 240 250
KTTEELKPEN IDMAIIKDSG KLVEKISVDE IEKIVKAVYE KVKAEEEEAE

KNKGEEDSE
Length:259
Mass (Da):28,514
Last modified:July 5, 2004 - v1
Checksum:i02FAFF238A6BC764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF29807.1
RefSeqiWP_011170195.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF29807; CAF29807; MMP0251
GeneIDi2761045
KEGGimmp:MMP0251
PATRICifig|267377.15.peg.254

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF29807.1
RefSeqiWP_011170195.1, NC_005791.1

3D structure databases

ProteinModelPortaliQ6M0L9
SMRiQ6M0L9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59085N
IntActiQ6M0L9, 3 interactors
STRINGi267377.MMP0251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF29807; CAF29807; MMP0251
GeneIDi2761045
KEGGimmp:MMP0251
PATRICifig|267377.15.peg.254

Phylogenomic databases

eggNOGiarCOG00971 Archaea
COG0638 LUCA
HOGENOMiHOG000091085
KOiK03432
OMAiFQVEYAR
OrthoDBiPOG093Z086S

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSA_METMP
AccessioniPrimary (citable) accession number: Q6M0L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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