UniProtKB - Q6M0F3 (ILVD_METMP)
Protein
Dihydroxy-acid dehydratase
Gene
ilvD
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Functioni
Catalytic activityi
- EC:4.2.1.9UniRule annotation
Cofactori
[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation
: L-isoleucine biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Acetolactate synthase (ilvB), Acetohydroxyacid synthase small subunit (ilvN)
- Ketol-acid reductoisomerase (NADP(+)) (ilvC)
- Dihydroxy-acid dehydratase (ilvD)
- Branched-chain-amino-acid aminotransferase (ilvE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: L-valine biosynthesis
This protein is involved in step 3 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Acetolactate synthase (ilvB), Acetohydroxyacid synthase small subunit (ilvN)
- Ketol-acid reductoisomerase (NADP(+)) (ilvC)
- Dihydroxy-acid dehydratase (ilvD)
- Branched-chain-amino-acid aminotransferase (ilvE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 119 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 | |
Metal bindingi | 191 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- dihydroxy-acid dehydratase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- isoleucine biosynthetic process Source: UniProtKB-UniRule
- valine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Branched-chain amino acid biosynthesis |
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
BioCyci | MMAR267377:MMP_RS01700-MONOMER |
UniPathwayi | UPA00047;UER00057 UPA00049;UER00061 |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)Short name: DADUniRule annotation |
Gene namesi | Name:ilvDUniRule annotation Ordered Locus Names:MMP0318 |
Organismi | Methanococcus maripaludis (strain S2 / LL) |
Taxonomic identifieri | 267377 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103544 | 1 – 550 | Dihydroxy-acid dehydrataseAdd BLAST | 550 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IlvD/Edd family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04045, Archaea |
HOGENOMi | CLU_014271_4_2_2 |
OMAi | IPGHVHL |
OrthoDBi | 7176at2157 |
Family and domain databases
Gene3Di | 3.50.30.80, 1 hit |
HAMAPi | MF_00012, IlvD, 1 hit |
InterProi | View protein in InterPro IPR042096, Dihydro-acid_dehy_C IPR004404, DihydroxyA_deHydtase IPR000581, DiOHA_6PGluconate_deHydtase IPR020558, DiOHA_6PGluconate_deHydtase_CS IPR037237, IlvD/EDD_N |
Pfami | View protein in Pfam PF00920, ILVD_EDD, 1 hit |
SUPFAMi | SSF143975, SSF143975, 1 hit |
TIGRFAMsi | TIGR00110, ilvD, 1 hit |
PROSITEi | View protein in PROSITE PS00886, ILVD_EDD_1, 1 hit PS00887, ILVD_EDD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6M0F3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISDNVKKGV IRTPNRALLK ACGYTDEDME KPFIGIVNSF TEVVPGHIHL
60 70 80 90 100
RTLSEAAKHG VYANGGTPFE FNTIGICDGI AMGHEGMKYS LPSREIIADA
110 120 130 140 150
VESMARAHGF DGLVLIPTCD KIVPGMIMGA LRLNIPFIVV TGGPMLPGEF
160 170 180 190 200
QGKKYELISL FEGVGEYQVG KITEEELKCI EDCACSGAGS CAGLYTANSM
210 220 230 240 250
ACLTEALGLS LPMCATTHAV DAQKVRLAKK SGSKIVDMVK EDLKPTDILT
260 270 280 290 300
KEAFENAILV DLALGGSTNT TLHIPAIANE IENKFITLDD FDRLSDEVPH
310 320 330 340 350
IASIKPGGEH YMIDLHNAGG IPAVLNVLKE KIRDTKTVDG RSILEIAESV
360 370 380 390 400
KYINYDVIRK VEAPVHETAG LRVLKGNLAP NGCVVKIGAV HPKMYKHDGP
410 420 430 440 450
AKVYNSEDEA ISAILGGKIV EGDVIVIRYE GPSGGPGMRE MLSPTSAICG
460 470 480 490 500
MGLDDSVALI TDGRFSGGSR GPCIGHVSPE AAAGGVIAAI ENGDIIKIDM
510 520 530 540 550
IEKEINVDLD ESVIKERLSK LGEFEPKIKK GYLSRYSKLV SSADEGAVLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF29874.1 |
RefSeqi | WP_011170262.1, NC_005791.1 |
Genome annotation databases
EnsemblBacteriai | CAF29874; CAF29874; MMP0318 |
GeneIDi | 2762188 |
KEGGi | mmp:MMP0318 |
PATRICi | fig|267377.15.peg.321 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF29874.1 |
RefSeqi | WP_011170262.1, NC_005791.1 |
3D structure databases
SMRi | Q6M0F3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 267377.MMP0318 |
Genome annotation databases
EnsemblBacteriai | CAF29874; CAF29874; MMP0318 |
GeneIDi | 2762188 |
KEGGi | mmp:MMP0318 |
PATRICi | fig|267377.15.peg.321 |
Phylogenomic databases
eggNOGi | arCOG04045, Archaea |
HOGENOMi | CLU_014271_4_2_2 |
OMAi | IPGHVHL |
OrthoDBi | 7176at2157 |
Enzyme and pathway databases
UniPathwayi | UPA00047;UER00057 UPA00049;UER00061 |
BioCyci | MMAR267377:MMP_RS01700-MONOMER |
Family and domain databases
Gene3Di | 3.50.30.80, 1 hit |
HAMAPi | MF_00012, IlvD, 1 hit |
InterProi | View protein in InterPro IPR042096, Dihydro-acid_dehy_C IPR004404, DihydroxyA_deHydtase IPR000581, DiOHA_6PGluconate_deHydtase IPR020558, DiOHA_6PGluconate_deHydtase_CS IPR037237, IlvD/EDD_N |
Pfami | View protein in Pfam PF00920, ILVD_EDD, 1 hit |
SUPFAMi | SSF143975, SSF143975, 1 hit |
TIGRFAMsi | TIGR00110, ilvD, 1 hit |
PROSITEi | View protein in PROSITE PS00886, ILVD_EDD_1, 1 hit PS00887, ILVD_EDD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ILVD_METMP | |
Accessioni | Q6M0F3Primary (citable) accession number: Q6M0F3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families