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Entry version 65 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

CAAX prenyl protease 2

Gene

rce1

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endopeptidase which proteolytically removes the C-terminal three residues of farnesylated peptides containing the CAAX motif where C is cysteine, A is an aliphatic amino acid and X is any amino acid. Cleaves the CAAX motif C-terminal to both P1 and P1' positions. Hydrolysis depends on a farnesylated cysteine residue and no activity is shown towards geranylgeranylated peptides.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is unaffected by metalloprotease inhibitors 5 mM EDTA and 5 mM Zn2+. Activity partially inhibited by 1,10-phenanthroline and 1,7-phenanthroline.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.175 s(-1) for peptide substrate DABCYL-ARSGAKASGC(farnesyl)LVS-EDANS.1 Publication
  1. KM=19.7 µM for peptide substrate DABCYL-ARSGAKASGC(farnesyl)LVS-EDANS where EDANS is 5-[(2-aminoethyl)amino]naphthalene-1-sulphonic acid fluorophore and DABCYL is 4-{[4-(dimethylamino)phenyl]azo}benzoic acid quencher1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Proton donor/acceptor1 Publication1
    Active sitei173Proton donor/acceptor1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei227Transition state stabilizer1 Publication1
    Sitei231Transition state stabilizer1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MMAR267377:MMP_RS02575-MONOMER

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M79.004

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    CAAX prenyl protease 21 Publication (EC:3.4.22.-1 Publication)
    Alternative name(s):
    Intramembrane protease Rce11 Publication
    Short name:
    IMP Rce11 Publication
    Prenyl protein-specific endoprotease 21 Publication
    Ras and a-factor-converting enzyme 11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:rce11 Publication
    Ordered Locus Names:MMP0485Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanococcus maripaludis (strain S2 / LL)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267377 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000590 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Extracellular1 Publication9
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30Helical; Name=11 PublicationAdd BLAST21
    Topological domaini31 – 38Cytoplasmic1 Publication8
    Transmembranei39 – 59Helical; Name=21 PublicationAdd BLAST21
    Topological domaini60 – 82Extracellular1 PublicationAdd BLAST23
    Transmembranei83 – 105Helical; Name=31 PublicationAdd BLAST23
    Topological domaini106 – 125Cytoplasmic1 PublicationAdd BLAST20
    Transmembranei126 – 149Helical; Name=41 PublicationAdd BLAST24
    Topological domaini150 – 159Extracellular1 Publication10
    Transmembranei160 – 179Helical; Name=51 PublicationAdd BLAST20
    Topological domaini180 – 192Cytoplasmic1 PublicationAdd BLAST13
    Transmembranei193 – 213Helical; Name=61 PublicationAdd BLAST21
    Topological domaini214 – 219Extracellular1 Publication6
    Transmembranei220 – 237Helical; Name=71 PublicationAdd BLAST18
    Topological domaini238 – 243Cytoplasmic1 Publication6
    Transmembranei244 – 263Helical; Name=81 PublicationAdd BLAST20
    Topological domaini264 – 271Extracellular1 Publication8

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45L → W: Decreased enzymatic activity to about 25 percent relative to wild-type. 1 Publication1
    Mutagenesisi132L → W: Decreased enzymatic activity to about 20 percent relative to wild-type. 1 Publication1
    Mutagenesisi140E → A or Q: Nearly loss of enzymatic activity. 1 Publication1
    Mutagenesisi141E → A: Decreased enzymatic activity to about 15 percent relative to wild-type. 1 Publication1
    Mutagenesisi173H → A: Strongly decreased enzymatic activity. 1 Publication1
    Mutagenesisi227H → A: Decreased enzymatic activity to about 20 percent relative to wild-type. 1 Publication1
    Mutagenesisi231N → A: Nearly loss of enzymatic activity. 1 Publication1
    Mutagenesisi231N → D: Decreased enzymatic activity to 40 percent relative to wild-type. At higher pH 8.0 nearly loss of enzymatic activity whereas the activity of the wild-type is unchanged. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004336421 – 271CAAX prenyl protease 2Add BLAST271

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    267377.MMP0485

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1271
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6LZY8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 135Poly-LeuSequence analysis6

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase U48 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    arCOG02768 Archaea
    COG1266 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000101458

    KEGG Orthology (KO)

    More...
    KOi
    K07052

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WHFPLIF

    Database of Orthologous Groups

    More...
    OrthoDBi
    59035at2157

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003675 CAAX_protease_2
    IPR042150 MmRce1-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR35797 PTHR35797, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02517 CPBP, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q6LZY8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MISSYKYNPK LYFLSTFVVT YILWFTGAYL SFSSTYSGIY MLIMLPGLMA
    60 70 80 90 100
    PFIISTILIA KSKNNELKKD FINRLFNLKL INLKTIPVVF LLMPAVILLS
    110 120 130 140 150
    ILLSIPFGGS ISQFQFSGGF SFSTDFVPVL FLLLLAATFE ELGWRGYAFD
    160 170 180 190 200
    SLQSRYSLFK ASILFGIFWS LWHFPLIFVN NSYQYEIFNQ SIWYGLNFFL
    210 220 230 240 250
    SILPMGIIIT WMCLKNRKSI ILAIIFHFLI NLNQELLAIT QDTKIIETGV
    260 270
    LFLVAAAIIL YDKKMFFEKL G
    Length:271
    Mass (Da):31,197
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i199EA975C25C7B9F
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX950229 Genomic DNA Translation: CAF30041.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_011170429.1, NC_005791.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    CAF30041; CAF30041; MMP0485

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2761751

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmp:MMP0485

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|267377.15.peg.491

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX950229 Genomic DNA Translation: CAF30041.1
    RefSeqiWP_011170429.1, NC_005791.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4CADX-ray2.50C/F/I/L1-271[»]
    SMRiQ6LZY8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi267377.MMP0485

    Protein family/group databases

    MEROPSiM79.004

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...
    ABCDi
    Q6LZY8

    Genome annotation databases

    EnsemblBacteriaiCAF30041; CAF30041; MMP0485
    GeneIDi2761751
    KEGGimmp:MMP0485
    PATRICifig|267377.15.peg.491

    Phylogenomic databases

    eggNOGiarCOG02768 Archaea
    COG1266 LUCA
    HOGENOMiHOG000101458
    KOiK07052
    OMAiWHFPLIF
    OrthoDBi59035at2157

    Enzyme and pathway databases

    BioCyciMMAR267377:MMP_RS02575-MONOMER

    Family and domain databases

    InterProiView protein in InterPro
    IPR003675 CAAX_protease_2
    IPR042150 MmRce1-like
    PANTHERiPTHR35797 PTHR35797, 1 hit
    PfamiView protein in Pfam
    PF02517 CPBP, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCE1_METMP
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LZY8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 16, 2015
    Last sequence update: July 5, 2004
    Last modified: December 11, 2019
    This is version 65 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Peptidase families
      Classification of peptidase families and list of entries
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