UniProtKB - Q6LZM2 (PYRF_METMP)
Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Functioni
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation
Catalytic activityi
- EC:4.1.1.23UniRule annotation
: UMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Orotate phosphoribosyltransferase (pyrE)
- Orotidine 5'-phosphate decarboxylase (pyrF)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 14 | SubstrateUniRule annotation | 1 | |
Binding sitei | 36 | SubstrateUniRule annotation | 1 | |
Active sitei | 66 | Proton donorUniRule annotation | 1 | |
Binding sitei | 120 | SubstrateUniRule annotation | 1 | |
Binding sitei | 197 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 198 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
- 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Pyrimidine biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00070;UER00120 |
Names & Taxonomyi
Protein namesi | Recommended name: Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)Alternative name(s): OMP decarboxylaseUniRule annotation Short name: OMPDCaseUniRule annotation Short name: OMPdecaseUniRule annotation |
Gene namesi | Name:pyrFUniRule annotation Ordered Locus Names:MMP0602 |
Organismi | Methanococcus maripaludis (strain S2 / LL) |
Taxonomic identifieri | 267377 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000241935 | 1 – 217 | Orotidine 5'-phosphate decarboxylaseAdd BLAST | 217 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 267377.MMP0602 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 73 | Substrate bindingUniRule annotation | 10 | |
Regioni | 172 – 182 | Substrate bindingUniRule annotationAdd BLAST | 11 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG00081, Archaea |
HOGENOMi | CLU_067069_2_0_2 |
OMAi | EMSHPGA |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01200_A, OMPdecase_type1_A, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR014732, OMPdecase IPR018089, OMPdecase_AS IPR001754, OMPdeCOase_dom IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR32119:SF2, PTHR32119:SF2, 1 hit |
Pfami | View protein in Pfam PF00215, OMPdecase, 1 hit |
SMARTi | View protein in SMART SM00934, OMPdecase, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR01740, pyrF, 1 hit |
PROSITEi | View protein in PROSITE PS00156, OMPDECASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6LZM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYGESLVKLM LALDVMDEKK AILIAKETSE YVDSIKIGYP LVLATGLNII
60 70 80 90 100
DKIKESTNKE VICDFKVADI PSTNEKIAEL TLNHADGIIC QGFVGSDSVS
110 120 130 140 150
AILNVARAKN KKVIVVTEMS HPGATEYLQN VAEDMAKMAD RLKVDGIVAP
160 170 180 190 200
STRPERLKEI KSIAKDAFVI SPGVGAQGGN LSDVLNVLNE NDYVIIGRAI
210
YENENPKNAA KKYKIQM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30158.1 |
Genome annotation databases
EnsemblBacteriai | CAF30158; CAF30158; MMP0602 |
KEGGi | mmp:MMP0602 |
PATRICi | fig|267377.15.peg.616 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30158.1 |
3D structure databases
SMRi | Q6LZM2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 267377.MMP0602 |
Genome annotation databases
EnsemblBacteriai | CAF30158; CAF30158; MMP0602 |
KEGGi | mmp:MMP0602 |
PATRICi | fig|267377.15.peg.616 |
Phylogenomic databases
eggNOGi | arCOG00081, Archaea |
HOGENOMi | CLU_067069_2_0_2 |
OMAi | EMSHPGA |
Enzyme and pathway databases
UniPathwayi | UPA00070;UER00120 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01200_A, OMPdecase_type1_A, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR014732, OMPdecase IPR018089, OMPdecase_AS IPR001754, OMPdeCOase_dom IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR32119:SF2, PTHR32119:SF2, 1 hit |
Pfami | View protein in Pfam PF00215, OMPdecase, 1 hit |
SMARTi | View protein in SMART SM00934, OMPdecase, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR01740, pyrF, 1 hit |
PROSITEi | View protein in PROSITE PS00156, OMPDECASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PYRF_METMP | |
Accessioni | Q6LZM2Primary (citable) accession number: Q6LZM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families