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Protein

Probable tRNA pseudouridine synthase D 2

Gene

truD2

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase D 2UniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase D 2UniRule annotation
tRNA-uridine isomerase D 2UniRule annotation
Gene namesi
Name:truD2UniRule annotation
Ordered Locus Names:MMP0615
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525451 – 390Probable tRNA pseudouridine synthase D 2Add BLAST390

Proteomic databases

PRIDEiQ6LZL0

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0615

Structurei

3D structure databases

ProteinModelPortaliQ6LZL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 353TRUDUniRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LZL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPININKFIL DMERFDGTLK KYPEDFIVEE ITPEGTVLEV GKEIGFEDVE
60 70 80 90 100
KWHGSFIHFT VEKTNWNTMD ALKQIVRATK TKRKNFGFAG TKDKFAVTTQ
110 120 130 140 150
RFGCFGLKKE QLENINIKDI VIRDVQKTNK KLRMGGLWGN KFTIKIRDLN
160 170 180 190 200
LSEKEIKRIS DLKLDYVLNY YGIQRFGLIR PITHIVGKFI YERDFESAFY
210 220 230 240 250
TYCGTPINET GDSLEARQLV DMGEFKKALK LFNRGHDYEK RLIQQYLKYK
260 270 280 290 300
DFKMAFTALP PQLNSMFVNA YQAYLFNEMI NKRFDYGFDE LEGDILEDNT
310 320 330 340 350
PTGTLIGYDT KFSGGIQGEI EKEIVERENL DLKKFKIEDF GNFYGTRRKM
360 370 380 390
VTPIYDFKSR FENEIFELSF KLERGNYATI VTREFTGNLS
Length:390
Mass (Da):45,732
Last modified:April 26, 2005 - v2
Checksum:i21BA1661FF5BB418
GO

Sequence cautioni

The sequence CAF30171 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30171.1 Different initiation.
RefSeqiWP_011170559.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF30171; CAF30171; MMP0615
GeneIDi2762160
KEGGimmp:MMP0615
PATRICifig|267377.15.peg.630

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30171.1 Different initiation.
RefSeqiWP_011170559.1, NC_005791.1

3D structure databases

ProteinModelPortaliQ6LZL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP0615

Proteomic databases

PRIDEiQ6LZL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF30171; CAF30171; MMP0615
GeneIDi2762160
KEGGimmp:MMP0615
PATRICifig|267377.15.peg.630

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD2_METMP
AccessioniPrimary (citable) accession number: Q6LZL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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