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Entry version 111 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA). Cannot use NADP instead of NAD.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.57 mM for NAD+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei207Proton donor/acceptorBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei207SubstrateBy similarity1
    Binding sitei258Substrate; via amide nitrogenBy similarity1
    Active sitei261NucleophileBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi11 – 28NADSequence analysisAdd BLAST18

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNAD

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MMAR267377:MMP_RS03695-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.336, 3262

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q6LZC3

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336)
    Alternative name(s):
    UDP-ManNAc 6-dehydrogenase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:wecC
    Ordered Locus Names:MMP0706
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanococcus maripaludis (strain S2 / LL)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267377 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000590 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003378361 – 427UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST427

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    267377.MMP0706

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6LZC3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 156SubstrateBy similarity2
    Regioni211 – 214SubstrateBy similarity4
    Regioni245 – 247Substrate; shared with dimeric partnerBy similarity3
    Regioni318 – 319SubstrateBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    arCOG00252, Archaea

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_023810_3_2_2

    KEGG Orthology (KO)

    More...
    KOi
    K02472

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GHCLPID

    Database of Orthologous Groups

    More...
    OrthoDBi
    41144at2157

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR036291, NAD(P)-bd_dom_sf
    IPR017476, UDP-Glc/GDP-Man
    IPR014027, UDP-Glc/GDP-Man_DH_C
    IPR036220, UDP-Glc/GDP-Man_DH_C_sf
    IPR014026, UDP-Glc/GDP-Man_DH_dimer
    IPR001732, UDP-Glc/GDP-Man_DH_N
    IPR028359, UDP_ManNAc/GlcNAc_DH

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00984, UDPG_MGDP_dh, 1 hit
    PF03720, UDPG_MGDP_dh_C, 1 hit
    PF03721, UDPG_MGDP_dh_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF500136, UDP_ManNAc_DH, 1 hit
    PIRSF000124, UDPglc_GDPman_dh, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00984, UDPG_MGDP_dh_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    SSF52413, SSF52413, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03026, NDP-sugDHase, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q6LZC3-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEKHGDYDIK KICVIGLGYI GLPTASMLAN HGYDVVGVDV NEKRVNQIKN
    60 70 80 90 100
    GELKIEEPGL LTLVKGAINS KNLNVRTSAT EADAFIICVP TPALAKEDGS
    110 120 130 140 150
    KKCDLSYVMS AVEAILPFVK DGNLIVIEST IPPETTKKIY ETLNKKIYVA
    160 170 180 190 200
    HCPERVLPGK ILKELVENDR IIGGINKKSA EMAKEIYKSF VEGQIYTTDS
    210 220 230 240 250
    NTAEMVKLME NTYRDINIAL ANEFAKICDE IGVNVWDAIK IANKHPRVNI
    260 270 280 290 300
    LNPGPGVGGH CISIDPWFIV EKTNNAKFIR AARELNDNMP AYVCNSVLSE
    310 320 330 340 350
    LKKLGIEKPK ISIFGATYKG NVEDTRESPS KNVIKMLLEN GATVSTYDPH
    360 370 380 390 400
    ASYFEYPLST LDECISGSDC IVVLTDHDVF KTIKKDDIDE ICPKLKNKIV
    410 420
    FDTKNILEHS LWKKAGFTVK LLGNGAW
    Length:427
    Mass (Da):47,252
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B5780FBFDAF6634
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX950229 Genomic DNA Translation: CAF30262.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_011170650.1, NC_005791.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    CAF30262; CAF30262; MMP0706

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2761881

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmp:MMP0706

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|267377.15.peg.723

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX950229 Genomic DNA Translation: CAF30262.1
    RefSeqiWP_011170650.1, NC_005791.1

    3D structure databases

    SMRiQ6LZC3
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi267377.MMP0706

    Genome annotation databases

    EnsemblBacteriaiCAF30262; CAF30262; MMP0706
    GeneIDi2761881
    KEGGimmp:MMP0706
    PATRICifig|267377.15.peg.723

    Phylogenomic databases

    eggNOGiarCOG00252, Archaea
    HOGENOMiCLU_023810_3_2_2
    KOiK02472
    OMAiGHCLPID
    OrthoDBi41144at2157

    Enzyme and pathway databases

    BioCyciMMAR267377:MMP_RS03695-MONOMER
    BRENDAi1.1.1.336, 3262
    SABIO-RKiQ6LZC3

    Family and domain databases

    InterProiView protein in InterPro
    IPR008927, 6-PGluconate_DH-like_C_sf
    IPR036291, NAD(P)-bd_dom_sf
    IPR017476, UDP-Glc/GDP-Man
    IPR014027, UDP-Glc/GDP-Man_DH_C
    IPR036220, UDP-Glc/GDP-Man_DH_C_sf
    IPR014026, UDP-Glc/GDP-Man_DH_dimer
    IPR001732, UDP-Glc/GDP-Man_DH_N
    IPR028359, UDP_ManNAc/GlcNAc_DH
    PfamiView protein in Pfam
    PF00984, UDPG_MGDP_dh, 1 hit
    PF03720, UDPG_MGDP_dh_C, 1 hit
    PF03721, UDPG_MGDP_dh_N, 1 hit
    PIRSFiPIRSF500136, UDP_ManNAc_DH, 1 hit
    PIRSF000124, UDPglc_GDPman_dh, 1 hit
    SMARTiView protein in SMART
    SM00984, UDPG_MGDP_dh_C, 1 hit
    SUPFAMiSSF48179, SSF48179, 1 hit
    SSF51735, SSF51735, 1 hit
    SSF52413, SSF52413, 1 hit
    TIGRFAMsiTIGR03026, NDP-sugDHase, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWECC_METMP
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LZC3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 5, 2004
    Last modified: August 12, 2020
    This is version 111 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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