UniProtKB - Q6LXQ1 (Q6LXQ1_METMP)
Protein
Formate dehydrogenase
Gene
fdhA
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Functioni
Catalytic activityi
- EC:1.17.1.9ARBA annotation
Cofactori
Protein has several cofactor binding sites:- Mo-bis(molybdopterin guanine dinucleotide)ARBA annotation
- [4Fe-4S] clusterARBA annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: InterPro
- formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- molybdopterin cofactor binding Source: InterPro
GO - Biological processi
- formate metabolic process Source: InterPro
Keywordsi
Molecular function | OxidoreductaseImported |
Ligand | Iron, Iron-sulfurARBA annotation, Metal-binding, NADARBA annotation, SeleniumImported |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-20163 MMAR267377:MMP_RS06685-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fdhAImported Ordered Locus Names:MMP1298Imported |
Organismi | Methanococcus maripaludis (strain S2 / LL)Imported |
Taxonomic identifieri | 267377 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 59 | 4Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST | 57 |
Phylogenomic databases
eggNOGi | arCOG01491, Archaea |
HOGENOMi | CLU_000422_4_0_2 |
OMAi | VCVKGAT |
Family and domain databases
CDDi | cd02790, MopB_CT_Formate-Dh_H, 1 hit cd02753, MopB_Formate-Dh-H, 1 hit |
InterProi | View protein in InterPro IPR009010, Asp_de-COase-like_dom_sf IPR041925, CT_Formate-Dh_H IPR041924, Formate_Dh-H_N IPR006478, Formate_DH_asu IPR006657, MoPterin_dinucl-bd_dom IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR006655, Mopterin_OxRdtase_prok_CS IPR027467, MopterinOxRdtase_cofactor_BS |
Pfami | View protein in Pfam PF04879, Molybdop_Fe4S4, 1 hit PF00384, Molybdopterin, 1 hit PF01568, Molydop_binding, 1 hit |
SMARTi | View protein in SMART SM00926, Molybdop_Fe4S4, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit |
TIGRFAMsi | TIGR01591, Fdh-alpha, 1 hit |
PROSITEi | View protein in PROSITE PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00551, MOLYBDOPTERIN_PROK_1, 1 hit PS00490, MOLYBDOPTERIN_PROK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6LXQ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELDFIHTIC PYCGTGCGVD LVVKDGTLVG TNPFKRHPVN EGKTCIKGSY
60 70 80 90 100
CHEFVHRDDR LKTPLIRKNG ELVEASWDEA LELISGKLQN YSPEEVGFFS
110 120 130 140 150
SARCTNEDNY VFQKFARTVI KTNNVDHCAR LUHSATVVGL GQAFGSGAMT
160 170 180 190 200
NSISDIEDAD CIFIIGSNTF EQHPLIARRV VRAKEKGTKI IVIDPRYTPT
210 220 230 240 250
AKQADLYLQL LPGTNIAVLN AIMHVLVKEN LVDEEFIKNR TKGYEELKTT
260 270 280 290 300
LETYTPEYAS KLSGVAPELI VEAAKMYGSA NAASILYCMG ITQFTTGVNN
310 320 330 340 350
VKSCCNLAMI TGNIGKPGTG VNPLRGQNNV QGACDMGALP NVFPGYQAVP
360 370 380 390 400
ANHEKYAEAW NTCVDPNVGL SIPDMLAKAG EQVKCIYVMG ENPMVSDPDI
410 420 430 440 450
HHVEHALKSL DLLIVQDIFL TETAQVADVV LPGASWAEKD GTFSNTERRI
460 470 480 490 500
QKINKAVDSP GEAIADWKIV KMLAEKMGQG ELFNFNTAEE VFQEIAKVTP
510 520 530 540 550
QYAGVTYERL GVDGLHWPCK TCEDPGTPIL HCEKCLTPDG LGNIFAIDYA
560 570 580 590 600
DPDEMADSEY PMTLTTGRII FHYHTGTMTR RSKHMADEIN EGFVEIHPED
610 620 630 640 650
AEKMGIKNKQ KVKVSTRRGE VVVNAKITPN IKQGVVFMPF HFAETAANIL
660 670
TNPAQDPNCK IPEYKVCAAK VEKI
Non-standard residue
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-standard residuei | 132 | SelenocysteineImported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30854.1 |
Genome annotation databases
EnsemblBacteriai | CAF30854; CAF30854; MMP1298 |
KEGGi | mmp:MMP1298 |
PATRICi | fig|267377.15.peg.1332 |
Keywords - Coding sequence diversityi
SelenocysteineImportedSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30854.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 267377.MMP1298 |
Genome annotation databases
EnsemblBacteriai | CAF30854; CAF30854; MMP1298 |
KEGGi | mmp:MMP1298 |
PATRICi | fig|267377.15.peg.1332 |
Phylogenomic databases
eggNOGi | arCOG01491, Archaea |
HOGENOMi | CLU_000422_4_0_2 |
OMAi | VCVKGAT |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-20163 MMAR267377:MMP_RS06685-MONOMER |
Family and domain databases
CDDi | cd02790, MopB_CT_Formate-Dh_H, 1 hit cd02753, MopB_Formate-Dh-H, 1 hit |
InterProi | View protein in InterPro IPR009010, Asp_de-COase-like_dom_sf IPR041925, CT_Formate-Dh_H IPR041924, Formate_Dh-H_N IPR006478, Formate_DH_asu IPR006657, MoPterin_dinucl-bd_dom IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR006655, Mopterin_OxRdtase_prok_CS IPR027467, MopterinOxRdtase_cofactor_BS |
Pfami | View protein in Pfam PF04879, Molybdop_Fe4S4, 1 hit PF00384, Molybdopterin, 1 hit PF01568, Molydop_binding, 1 hit |
SMARTi | View protein in SMART SM00926, Molybdop_Fe4S4, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit |
TIGRFAMsi | TIGR01591, Fdh-alpha, 1 hit |
PROSITEi | View protein in PROSITE PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00551, MOLYBDOPTERIN_PROK_1, 1 hit PS00490, MOLYBDOPTERIN_PROK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6LXQ1_METMP | |
Accessioni | Q6LXQ1Primary (citable) accession number: Q6LXQ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | February 10, 2021 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |