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UniProtKB - Q6LXQ1 (Q6LXQ1_METMP)

Entry version 50 (07 Apr 2021)
Sequence version 1 (03 May 2011)
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Protein

Formate dehydrogenase

Gene

fdhA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
LigandIron, Iron-sulfurARBA annotation, Metal-binding, NADARBA annotation, SeleniumImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-20163
MMAR267377:MMP_RS06685-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formate dehydrogenaseARBA annotation (EC:1.17.1.9ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fdhAImported
Ordered Locus Names:MMP1298Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanococcus maripaludis (strain S2 / LL)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000590 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		267377.MMP1298

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 594Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		arCOG01491, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000422_4_0_2

Identification of Orthologs from Complete Genome Data

More...OMAi		VCVKGAT

Family and domain databases

Conserved Domains Database

More...CDDi		cd02790, MopB_CT_Formate-Dh_H, 1 hit
cd02753, MopB_Formate-Dh-H, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR041925, CT_Formate-Dh_H
IPR041924, Formate_Dh-H_N
IPR006478, Formate_DH_asu
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01591, Fdh-alpha, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6LXQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDFIHTIC PYCGTGCGVD LVVKDGTLVG TNPFKRHPVN EGKTCIKGSY 
        60         70         80         90        100
CHEFVHRDDR LKTPLIRKNG ELVEASWDEA LELISGKLQN YSPEEVGFFS 
       110        120        130        140        150
SARCTNEDNY VFQKFARTVI KTNNVDHCAR LUHSATVVGL GQAFGSGAMT 
       160        170        180        190        200
NSISDIEDAD CIFIIGSNTF EQHPLIARRV VRAKEKGTKI IVIDPRYTPT 
       210        220        230        240        250
AKQADLYLQL LPGTNIAVLN AIMHVLVKEN LVDEEFIKNR TKGYEELKTT 
       260        270        280        290        300
LETYTPEYAS KLSGVAPELI VEAAKMYGSA NAASILYCMG ITQFTTGVNN 
       310        320        330        340        350
VKSCCNLAMI TGNIGKPGTG VNPLRGQNNV QGACDMGALP NVFPGYQAVP 
       360        370        380        390        400
ANHEKYAEAW NTCVDPNVGL SIPDMLAKAG EQVKCIYVMG ENPMVSDPDI 
       410        420        430        440        450
HHVEHALKSL DLLIVQDIFL TETAQVADVV LPGASWAEKD GTFSNTERRI 
       460        470        480        490        500
QKINKAVDSP GEAIADWKIV KMLAEKMGQG ELFNFNTAEE VFQEIAKVTP 
       510        520        530        540        550
QYAGVTYERL GVDGLHWPCK TCEDPGTPIL HCEKCLTPDG LGNIFAIDYA 
       560        570        580        590        600
DPDEMADSEY PMTLTTGRII FHYHTGTMTR RSKHMADEIN EGFVEIHPED 
       610        620        630        640        650
AEKMGIKNKQ KVKVSTRRGE VVVNAKITPN IKQGVVFMPF HFAETAANIL 
       660        670 
TNPAQDPNCK IPEYKVCAAK VEKI
Length:674
Mass (Da):74,225
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DAB8BE5FCEDA186
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei132SelenocysteineImported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30854.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmp:MMP1298

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|267377.15.peg.1332

Keywords - Coding sequence diversityi

SelenocysteineImported

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30854.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi267377.MMP1298

Genome annotation databases

KEGGimmp:MMP1298
PATRICifig|267377.15.peg.1332

Phylogenomic databases

eggNOGiarCOG01491, Archaea
HOGENOMiCLU_000422_4_0_2
OMAiVCVKGAT

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20163
MMAR267377:MMP_RS06685-MONOMER

Family and domain databases

CDDicd02790, MopB_CT_Formate-Dh_H, 1 hit
cd02753, MopB_Formate-Dh-H, 1 hit
InterProiView protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR041925, CT_Formate-Dh_H
IPR041924, Formate_Dh-H_N
IPR006478, Formate_DH_asu
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS
PfamiView protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit
SMARTiView protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR01591, Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6LXQ1_METMP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LXQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 7, 2021
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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