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Entry version 49 (10 Feb 2021)
Sequence version 1 (03 May 2011)
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Protein

Formate dehydrogenase

Gene

fdhA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
LigandIron, Iron-sulfurARBA annotation, Metal-binding, NADARBA annotation, SeleniumImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-20163
MMAR267377:MMP_RS06685-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formate dehydrogenaseARBA annotation (EC:1.17.1.9ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fdhAImported
Ordered Locus Names:MMP1298Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanococcus maripaludis (strain S2 / LL)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000590 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
267377.MMP1298

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 594Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd BLAST57

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG01491, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000422_4_0_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCVKGAT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02790, MopB_CT_Formate-Dh_H, 1 hit
cd02753, MopB_Formate-Dh-H, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR041925, CT_Formate-Dh_H
IPR041924, Formate_Dh-H_N
IPR006478, Formate_DH_asu
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01591, Fdh-alpha, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6LXQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDFIHTIC PYCGTGCGVD LVVKDGTLVG TNPFKRHPVN EGKTCIKGSY
60 70 80 90 100
CHEFVHRDDR LKTPLIRKNG ELVEASWDEA LELISGKLQN YSPEEVGFFS
110 120 130 140 150
SARCTNEDNY VFQKFARTVI KTNNVDHCAR LUHSATVVGL GQAFGSGAMT
160 170 180 190 200
NSISDIEDAD CIFIIGSNTF EQHPLIARRV VRAKEKGTKI IVIDPRYTPT
210 220 230 240 250
AKQADLYLQL LPGTNIAVLN AIMHVLVKEN LVDEEFIKNR TKGYEELKTT
260 270 280 290 300
LETYTPEYAS KLSGVAPELI VEAAKMYGSA NAASILYCMG ITQFTTGVNN
310 320 330 340 350
VKSCCNLAMI TGNIGKPGTG VNPLRGQNNV QGACDMGALP NVFPGYQAVP
360 370 380 390 400
ANHEKYAEAW NTCVDPNVGL SIPDMLAKAG EQVKCIYVMG ENPMVSDPDI
410 420 430 440 450
HHVEHALKSL DLLIVQDIFL TETAQVADVV LPGASWAEKD GTFSNTERRI
460 470 480 490 500
QKINKAVDSP GEAIADWKIV KMLAEKMGQG ELFNFNTAEE VFQEIAKVTP
510 520 530 540 550
QYAGVTYERL GVDGLHWPCK TCEDPGTPIL HCEKCLTPDG LGNIFAIDYA
560 570 580 590 600
DPDEMADSEY PMTLTTGRII FHYHTGTMTR RSKHMADEIN EGFVEIHPED
610 620 630 640 650
AEKMGIKNKQ KVKVSTRRGE VVVNAKITPN IKQGVVFMPF HFAETAANIL
660 670
TNPAQDPNCK IPEYKVCAAK VEKI
Length:674
Mass (Da):74,225
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DAB8BE5FCEDA186
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei132SelenocysteineImported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30854.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAF30854; CAF30854; MMP1298

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmp:MMP1298

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|267377.15.peg.1332

Keywords - Coding sequence diversityi

SelenocysteineImported

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30854.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi267377.MMP1298

Genome annotation databases

EnsemblBacteriaiCAF30854; CAF30854; MMP1298
KEGGimmp:MMP1298
PATRICifig|267377.15.peg.1332

Phylogenomic databases

eggNOGiarCOG01491, Archaea
HOGENOMiCLU_000422_4_0_2
OMAiVCVKGAT

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20163
MMAR267377:MMP_RS06685-MONOMER

Family and domain databases

CDDicd02790, MopB_CT_Formate-Dh_H, 1 hit
cd02753, MopB_Formate-Dh-H, 1 hit
InterProiView protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR041925, CT_Formate-Dh_H
IPR041924, Formate_Dh-H_N
IPR006478, Formate_DH_asu
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006963, Mopterin_OxRdtase_4Fe-4S_dom
IPR006655, Mopterin_OxRdtase_prok_CS
IPR027467, MopterinOxRdtase_cofactor_BS
PfamiView protein in Pfam
PF04879, Molybdop_Fe4S4, 1 hit
PF00384, Molybdopterin, 1 hit
PF01568, Molydop_binding, 1 hit
SMARTiView protein in SMART
SM00926, Molybdop_Fe4S4, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR01591, Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51669, 4FE4S_MOW_BIS_MGD, 1 hit
PS00551, MOLYBDOPTERIN_PROK_1, 1 hit
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6LXQ1_METMP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LXQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: February 10, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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