Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lactaldehyde dehydrogenase

Gene

MMP1487

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.By similarity

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei274PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 225NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMMAR267377:MMP_RS07645-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Gene namesi
Ordered Locus Names:MMP1487
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425921 – 465Lactaldehyde dehydrogenaseAdd BLAST465

Proteomic databases

PRIDEiQ6LX65

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi267377.MMP1487

Structurei

3D structure databases

ProteinModelPortaliQ6LX65
SMRiQ6LX65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG01252 Archaea
COG1012 LUCA
HOGENOMiHOG000271509
KOiK19266
OMAiYNVIPCS
OrthoDBiPOG093Z01H3

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LX65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDGKWIIR EDIDVFDPYT LENIEKITAL DREETKNAIE VTEKHKEIMK
60 70 80 90 100
NLSPSKRYKI LMKVAEHLSS KKDFFAKTIS IDVGKPIKQS KIEVDRTLTA
110 120 130 140 150
LKLSAFYAKE LRGETINSEN GLIFTKKEPL GVIGAITPFN FPLNLATHKI
160 170 180 190 200
GPAIATGNSV VLHPSSKAPI VAIYLTKIIE HVLKQMDIPR GVFNLATGNG
210 220 230 240 250
EIVGDEISKN DNVNMVSFTG SVEVGESISK NAKMKKVTLE LGGNNPMIVL
260 270 280 290 300
KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVVETF TKYVIEETKK
310 320 330 340 350
LILGNPLDKN TDIGPLISPE SALRIENLIK QSVSEGGELL IGGNRQNSLI
360 370 380 390 400
SPAVINIDEE NILSKIETFG PILPILTVKD SEEAVNIANN SKYGLQAGLF
410 420 430 440 450
TNNINNAMKI ADELEYGGIM INSSPTFRKD NMPFGGVKKS GLGREGIKYT
460
VEEMSETKTV VIHNI
Length:465
Mass (Da):50,981
Last modified:July 5, 2004 - v1
Checksum:iA70FE58C9B30D8A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF31043.1
RefSeqiWP_011171431.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF31043; CAF31043; MMP1487
GeneIDi2762736
KEGGimmp:MMP1487
PATRICifig|267377.15.peg.1523

Similar proteinsi

Entry informationi

Entry nameiLADH_METMP
AccessioniPrimary (citable) accession number: Q6LX65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health