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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.1 Publication

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).Curated
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstrateBy similarity1
Binding sitei52Substrate; via amide nitrogenBy similarity1
Binding sitei78Pyridoxal phosphateBy similarity1
Binding sitei116SubstrateBy similarity1
Binding sitei140Pyridoxal phosphateBy similarity1
Binding sitei140SubstrateBy similarity1
Binding sitei190Pyridoxal phosphateBy similarity1
Binding sitei190SubstrateBy similarity1
Binding sitei221Pyridoxal phosphateBy similarity1
Binding sitei259Pyridoxal phosphateBy similarity1

GO - Molecular functioni

  • L,L-diaminopimelate aminotransferase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase1 Publication (EC:2.6.1.83By similarity)
Short name:
DAP-AT1 Publication
Short name:
DAP-aminotransferase1 Publication
Short name:
LL-DAP-aminotransferase1 Publication
Gene namesi
Name:dapL
Ordered Locus Names:MMP1527
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are unable to grow in the absence of exogenous L-lysine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422591 – 416LL-diaminopimelate aminotransferaseAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi267377.MMP1527

Structurei

3D structure databases

ProteinModelPortaliQ6LX26
SMRiQ6LX26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 116Pyridoxal phosphate bindingBy similarity2
Regioni248 – 250Pyridoxal phosphate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01133 Archaea
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiYPHMPTG
OrthoDBiPOG093Z02O6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LX26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESYIQNLFA ERIGGKSFGK EDVIYKFEKI KRAKQAAKLK YPDMELIDMG
60 70 80 90 100
VGEPDEMADE SVVEVLCEEA KKHVNRGYSD NGVQALKDEI PIYLEKIFGV
110 120 130 140 150
KDLDPVNEVV HSIGSKPALA YITSVFINPG DVTLMTVPGY PVTATHTKWY
160 170 180 190 200
GGSVETLPLL EKNNFLPELD AISKEVRENA KILYLNYPNN PTGAQATKKF
210 220 230 240 250
YKEAVDFAFE NDLIVIQDAA YAALTYGDKP LSFLSVKDAK EVGVEIHSFS
260 270 280 290 300
KAYNMTGWRL AFVAGNELIV RGFAAVKDNY DSGQFIPIQK AGIHCLRHPE
310 320 330 340 350
ITEKTRAKYE RRLSKMVKIL KEAGFNAKMP GGTFYLYVKA PIGTKDGAKF
360 370 380 390 400
ANAEEFSQFM IKEKLISTVP WDDAGNFVRM AACFEAFKDG EISIEEEDRI
410
LNEVKRRLTE VEFVFE
Length:416
Mass (Da):46,764
Last modified:July 5, 2004 - v1
Checksum:i8D3A9D91C9275F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF31083.1
RefSeqiWP_011171471.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF31083; CAF31083; MMP1527
GeneIDi2761821
KEGGimmp:MMP1527
PATRICifig|267377.15.peg.1564

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF31083.1
RefSeqiWP_011171471.1, NC_005791.1

3D structure databases

ProteinModelPortaliQ6LX26
SMRiQ6LX26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP1527

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF31083; CAF31083; MMP1527
GeneIDi2761821
KEGGimmp:MMP1527
PATRICifig|267377.15.peg.1564

Phylogenomic databases

eggNOGiarCOG01133 Archaea
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiYPHMPTG
OrthoDBiPOG093Z02O6

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_METMP
AccessioniPrimary (citable) accession number: Q6LX26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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