UniProtKB - Q6LWX0 (Q6LWX0_METMP)
Protein
Polyamine aminopropyltransferase
Gene
speE
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Functioni
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H+ + S-methyl-5'-thioadenosine + spermidineUniRule annotationEC:2.5.1.16UniRule annotation
: spermidine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes spermidine from putrescine.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Polyamine aminopropyltransferase (speE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes spermidine from putrescine, the pathway spermidine biosynthesis and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 9 | PolyamineUniRule annotation | 1 | |
Binding sitei | 33 | S-adenosylmethioninamineUniRule annotation | 1 | |
Binding sitei | 64 | PolyamineUniRule annotation | 1 | |
Binding sitei | 88 | PolyamineUniRule annotation | 1 | |
Binding sitei | 108 | S-adenosylmethioninamineUniRule annotation | 1 | |
Active sitei | 157 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 164 | S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation | 1 |
GO - Molecular functioni
- spermidine synthase activity Source: UniProtKB-UniRule
GO - Biological processi
- spermidine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | TransferaseUniRule annotationARBA annotation |
Biological process | Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation |
Enzyme and pathway databases
BioCyci | MMAR267377:MMP_RS08145-MONOMER |
UniPathwayi | UPA00248;UER00314 |
Names & Taxonomyi
Protein namesi | Recommended name: Polyamine aminopropyltransferaseUniRule annotationAlternative name(s): Putrescine aminopropyltransferaseUniRule annotation Short name: PAPTUniRule annotation Spermidine synthaseUniRule annotation (EC:2.5.1.16UniRule annotation) Short name: SPDSUniRule annotation Short name: SPDSYUniRule annotation |
Gene namesi | Name:speEUniRule annotation Ordered Locus Names:MMP1584Imported |
Organismi | Methanococcus maripaludis (strain S2 / LL)Imported |
Taxonomic identifieri | 267377 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › |
Proteomesi |
|
Interactioni
Subunit structurei
Homodimer or homotetramer.
UniRule annotationProtein-protein interaction databases
STRINGi | 267377.MMP1584 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 238 | PABSInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 139 – 140 | S-adenosylmethioninamine bindingUniRule annotation | 2 | |
Regioni | 158 – 160 | Polyamine bindingUniRule annotation | 3 |
Sequence similaritiesi
Belongs to the spermidine/spermine synthase family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00050, Archaea |
HOGENOMi | CLU_048199_1_0_2 |
OMAi | SDMWPGQ |
OrthoDBi | 77175at2157 |
Family and domain databases
Gene3Di | 2.30.140.10, 1 hit |
HAMAPi | MF_00198, Spermidine_synth, 1 hit |
InterProi | View protein in InterPro IPR030374, PABS IPR030373, PABS_CS IPR029063, SAM-dependent_MTases IPR001045, Spermi_synthase IPR035246, Spermidine_synt_N IPR037163, Spermidine_synt_N_sf |
Pfami | View protein in Pfam PF17284, Spermine_synt_N, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR00417, speE, 1 hit |
PROSITEi | View protein in PROSITE PS01330, PABS_1, 1 hit PS51006, PABS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6LWX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFDAWYTEP QTENLSLSTK LKDILYVGQS EYQEIQVLDT YEFGRVLILE
60 70 80 90 100
NTYQTTERDE FIYHELISHP ALFTHGNPKK VLVIGGGDGG SVREVLKHKS
110 120 130 140 150
VEKIDFVELD GQVVEVAKKF LPTLSCEIDN EKVNTIITDG IKYVAETSEK
160 170 180 190 200
YDVILVDCPD PVGPAAGLFE KEFYNNLYKC LNDDGIMVQQ TESPLLHEKL
210 220 230 240 250
INKIKGHLKD AGFSTIRPLV CSIPTYPSGF WSFTLASKKN DPLNSDVSEI
260 270 280
ENKLKDMTTK YYDQDVHKGV FLATPRYLKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF31140.1 |
RefSeqi | WP_011171528.1, NC_005791.1 |
Genome annotation databases
EnsemblBacteriai | CAF31140; CAF31140; MMP1584 |
GeneIDi | 2761959 |
KEGGi | mmp:MMP1584 |
PATRICi | fig|267377.15.peg.1623 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF31140.1 |
RefSeqi | WP_011171528.1, NC_005791.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 267377.MMP1584 |
Genome annotation databases
EnsemblBacteriai | CAF31140; CAF31140; MMP1584 |
GeneIDi | 2761959 |
KEGGi | mmp:MMP1584 |
PATRICi | fig|267377.15.peg.1623 |
Phylogenomic databases
eggNOGi | arCOG00050, Archaea |
HOGENOMi | CLU_048199_1_0_2 |
OMAi | SDMWPGQ |
OrthoDBi | 77175at2157 |
Enzyme and pathway databases
UniPathwayi | UPA00248;UER00314 |
BioCyci | MMAR267377:MMP_RS08145-MONOMER |
Family and domain databases
Gene3Di | 2.30.140.10, 1 hit |
HAMAPi | MF_00198, Spermidine_synth, 1 hit |
InterProi | View protein in InterPro IPR030374, PABS IPR030373, PABS_CS IPR029063, SAM-dependent_MTases IPR001045, Spermi_synthase IPR035246, Spermidine_synt_N IPR037163, Spermidine_synt_N_sf |
Pfami | View protein in Pfam PF17284, Spermine_synt_N, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR00417, speE, 1 hit |
PROSITEi | View protein in PROSITE PS01330, PABS_1, 1 hit PS51006, PABS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6LWX0_METMP | |
Accessioni | Q6LWX0Primary (citable) accession number: Q6LWX0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |