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Entry version 105 (26 Feb 2020)
Sequence version 2 (26 Feb 2008)
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Protein

H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit A

Gene

hdrA

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme M-coenzyme B heterodisulfide reduction

This protein is involved in step 1 of the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit C2 (hdrC2), CoB--CoM heterodisulfide reductase iron-sulfur subunit A (hdrA), H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit B1 (hdrB1), H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit B2 (hdrB2), H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit A (hdrA), H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit C1 (hdrC1)
This subpathway is part of the pathway coenzyme M-coenzyme B heterodisulfide reduction, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide, the pathway coenzyme M-coenzyme B heterodisulfide reduction and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi246Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi249Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi252Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi256Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi293Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi296Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi299Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi303Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi584Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi587Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi590Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi594Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi617Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi620Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi623Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi627Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi150 – 173FADSequence analysisAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-20165
MMAR267377:MMP_RS08740-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.8.98.1 3262

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00647;UER00700

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit ACurated (EC:1.8.98.51 Publication, EC:1.8.98.62 Publications)
Alternative name(s):
CoB--CoM heterodisulfide reductase iron-sulfur subunit ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hdrA
Ordered Locus Names:MMP1697
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanococcus maripaludis (strain S2 / LL)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000590 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003186461 – 658H(2)/formate:CoB-CoM heterodisulfide,ferredoxin reductase subunit AAdd BLAST658

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6LWL2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. B1 and B2 subunits are interchangeable, as are the C1 and C2 subunits. The heterodisulfide reductase forms a supercomplex with formylmethanofuran dehydrogenase (Fwd), F(420)-non-reducing hydrogenase (Vhu) and formate dehydrogenase (Fdh).

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
267377.MMP1697

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini236 – 2674Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST32
Domaini284 – 3134Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini575 – 6044Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini607 – 6374Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HdrA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG02235 Archaea
COG1148 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020302_0_0_2

KEGG Orthology (KO)

More...
KOi
K03388

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPSGAMQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR039650 HdrA-like

The PANTHER Classification System

More...
PANTHERi
PTHR43498 PTHR43498, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00037 Fer4, 1 hit
PF12838 Fer4_7, 1 hit
PF07992 Pyr_redox_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 3 hits
PS51379 4FE4S_FER_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6LWL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPKVGVFV CYCGANINGA VDCEAVKDFA SELDGVAVAA TYPFMCADPG
60 70 80 90 100
QGLIKDAIKE HGLDRIVVAA CTPKIHEPTF RGCLQDAGIS PYYLEFVNIR
110 120 130 140 150
EHDAFVHMGD VEGATRKACE MIAGGVERAK KLEDVPQKVV DVDKSCMVIG
160 170 180 190 200
AGIAGIQSAL DLGDQGFKVY LVDKDESIGG RMAQLAKTFP TDDCAMUILA
210 220 230 240 250
PKMVSAANHP NIELITFAEI KNIDGYIGNF DVTLEKKPRY VDEDTCTGCG
260 270 280 290 300
ACAAACPIEV PNEFDLGLGT RKAIYVPFPQ AVPLLYTIDK EHCIDCGLCA
310 320 330 340 350
KVCCAEAVRY DQKPQELNIK VGTIITATGY DEFDATKKEE YGYGVYDNVI
360 370 380 390 400
TTLEVERMIN PAGPTHGHEI RPSDGKAPKR TVYIQCVGSR DEKVGNPYCS
410 420 430 440 450
RVCCMFALKN AQLMKMHDPN AEVYICYMDI RAFGKGYEEY YKRAQDQFGV
460 470 480 490 500
KFIRGRPANI FEDPETKNLT VRVEDTLMGE ILEIDADLVV LSAGLEAKKD
510 520 530 540 550
AGELAKMLGI DRGPEGFFKE LHPKLAPVNT KVDGIAIAGV AQGPKDIPDT
560 570 580 590 600
VAQAKGAASA VAIPMSQGQF KIEMIRATVN EEVCGGCKVC ALMCPYNAIT
610 620 630 640 650
YEEKDGHLVA ITDDVACKGC GACAAACPSG AMQLRYYRDE QVIGMIDGIL

NAAKMLEE
Length:658
Mass (Da):71,281
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0218716DA82E3866
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei197SelenocysteineCurated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF31253.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAF31253; CAF31253; MMP1697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmp:MMP1697

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|267377.15.peg.1739

Keywords - Coding sequence diversityi

Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF31253.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi267377.MMP1697

Proteomic databases

PRIDEiQ6LWL2

Genome annotation databases

EnsemblBacteriaiCAF31253; CAF31253; MMP1697
KEGGimmp:MMP1697
PATRICifig|267377.15.peg.1739

Phylogenomic databases

eggNOGiarCOG02235 Archaea
COG1148 LUCA
HOGENOMiCLU_020302_0_0_2
KOiK03388
OMAiCPSGAMQ

Enzyme and pathway databases

UniPathwayiUPA00647;UER00700
BioCyciMetaCyc:MONOMER-20165
MMAR267377:MMP_RS08740-MONOMER
BRENDAi1.8.98.1 3262

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR039650 HdrA-like
PANTHERiPTHR43498 PTHR43498, 1 hit
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF12838 Fer4_7, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 3 hits
PS51379 4FE4S_FER_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDRA_METMP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LWL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 26, 2020
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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