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Protein

Glutamate 5-kinase

Gene

proB

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20ATPUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Binding sitei147SubstrateUniRule annotation1
Binding sitei159Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 180ATPUniRule annotation2
Nucleotide bindingi221 – 227ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:PBPRA0839
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001097041 – 378Glutamate 5-kinaseAdd BLAST378

Proteomic databases

PRIDEiQ6LTX3

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA0839

Structurei

3D structure databases

ProteinModelPortaliQ6LTX3
SMRiQ6LTX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 364PUAUniRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
HOGENOMiHOG000246368
KOiK00931
OMAiTHEIRFG
OrthoDBiPOG091H00OF

Family and domain databases

Gene3Di2.30.130.10, 1 hit
3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LTX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPLSDKQT LPPKQTIVVK LGTSVLTGGT LKLDRAHMVE LVRQCAYLRR
60 70 80 90 100
YGHKVIIVTS GAIAAGREHL DYPELPKTMA SKQLLAAVGQ SRLIQEWESL
110 120 130 140 150
FGIYGLHVGQ MLLTRADLDD RERYLNARDM LIALLDNGII PVVNENDAVA
160 170 180 190 200
TTEIKVGDND NLSALVGILG GADKLLLLTD QPGLFTADPR NNPDAELIRE
210 220 230 240 250
VHTIDETLRK LAGGSAGGLG TGGMATKLQA ADVARRAGIE VIIAAGSRPD
260 270 280 290 300
VISDLASGES VGTRFLPLDT PLESRKRWIL AGPPPAGDIV IDAGAAKAVL
310 320 330 340 350
ERGSSLLSKG ISEVKGAFER GEVARIFDTN GVLLARGICR YSSRDMAMIV
360 370
GKHSQEIYKV LGYEYGPVAI HRDDLVVI
Length:378
Mass (Da):40,523
Last modified:July 5, 2004 - v1
Checksum:i81E7943C9C30EDB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378665 Genomic DNA Translation: CAG19252.1
RefSeqiWP_011217589.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG19252; CAG19252; PBPRA0839
KEGGippr:PBPRA0839

Similar proteinsi

Entry informationi

Entry nameiPROB_PHOPR
AccessioniPrimary (citable) accession number: Q6LTX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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