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Protein

Two-component response regulator-like APRR5

Gene

APRR5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Negative regulator of shade avoidance response. Involved in the inhibition of leaf expansion in shade avoidance response.5 Publications

Miscellaneous

The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock.1 Publication

Caution

Lacks the phospho-accepting Asp (here Glu-102), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

GO - Biological processi

Keywordsi

Biological processBiological rhythms, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component response regulator-like APRR5
Alternative name(s):
Pseudo-response regulator 5
Gene namesi
Name:APRR5
Ordered Locus Names:At5g24470
ORF Names:T31K7.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G24470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814371 – 558Two-component response regulator-like APRR5Add BLAST558

Post-translational modificationi

Phosphorylation varies throughout the diurnal cycle and enhances ADO1 binding.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6LA42

PTM databases

iPTMnetiQ6LA42

Expressioni

Gene expression databases

ExpressionAtlasiQ6LA42 baseline and differential
GenevisibleiQ6LA42 AT

Interactioni

Subunit structurei

Interacts with ADO1 and ADO2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APRR1Q9LKL25EBI-1536669,EBI-618423

Protein-protein interaction databases

BioGridi17793, 14 interactors
IntActiQ6LA42, 3 interactors
MINTiQ6LA42
STRINGi3702.AT5G24470.1

Structurei

3D structure databases

ProteinModelPortaliQ6LA42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 169Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini509 – 551CCTPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 260Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ARR-like family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000034018
InParanoidiQ6LA42
KOiK12130
OrthoDBiEOG093604X6
PhylomeDBiQ6LA42

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR010402 CCT_domain
IPR011006 CheY-like_superfamily
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF06203 CCT, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51017 CCT, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LA42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSEEVVEV TVVKAPEAGG GKLSRRKIRK KDAGVDGLVK WERFLPKIAL
60 70 80 90 100
RVLLVEADDS TRQIIAALLR KCSYRVAAVP DGLKAWEMLK GKPESVDLIL
110 120 130 140 150
TEVDLPSISG YALLTLIMEH DICKNIPVIM MSTQDSVNTV YKCMLKGAAD
160 170 180 190 200
YLVKPLRRNE LRNLWQHVWR RQTSLAPDSF PWNESVGQQK AEGASANNSN
210 220 230 240 250
GKRDDHVVSG NGGDAQSSCT RPEMEGESAD VEVSARDAVQ MECAKSQFNE
260 270 280 290 300
TRLLANELQS KQAEAIDFMG ASFRRTGRRN REESVAQYES RIELDLSLRR
310 320 330 340 350
PNASENQSSG DRPSLHPSSA SAFTRYVHRP LQTQCSASPV VTDQRKNVAA
360 370 380 390 400
SQDDNIVLMN QYNTSEPPPN APRRNDTSFY TGADSPGPPF SNQLNSWPGQ
410 420 430 440 450
SSYPTPTPIN NIQFRDPNTA YTSAMAPASL SPSPSSVSPH EYSSMFHPFN
460 470 480 490 500
SKPEGLQDRD CSMDVDERRY VSSATEHSAI GNHIDQLIEK KNEDGYSLSV
510 520 530 540 550
GKIQQSLQRE AALTKFRMKR KDRCYEKKVR YESRKKLAEQ RPRIKGQFVR

QVQSTQAP
Length:558
Mass (Da):62,301
Last modified:September 27, 2004 - v2
Checksum:i9813089FA9DC8CE9
GO

Sequence cautioni

The sequence BAB13743 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046955 mRNA Translation: BAB13743.1 Different initiation.
AB025641 Genomic DNA Translation: BAB08930.1
CP002688 Genomic DNA Translation: AED93314.2
AY062114 mRNA Translation: AAL32986.1
AY143934 mRNA Translation: AAN28873.1
RefSeqiNP_568446.2, NM_122355.4
UniGeneiAt.21641

Genome annotation databases

EnsemblPlantsiAT5G24470.1; AT5G24470.1; AT5G24470
GeneIDi832518
GrameneiAT5G24470.1; AT5G24470.1; AT5G24470
KEGGiath:AT5G24470

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046955 mRNA Translation: BAB13743.1 Different initiation.
AB025641 Genomic DNA Translation: BAB08930.1
CP002688 Genomic DNA Translation: AED93314.2
AY062114 mRNA Translation: AAL32986.1
AY143934 mRNA Translation: AAN28873.1
RefSeqiNP_568446.2, NM_122355.4
UniGeneiAt.21641

3D structure databases

ProteinModelPortaliQ6LA42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17793, 14 interactors
IntActiQ6LA42, 3 interactors
MINTiQ6LA42
STRINGi3702.AT5G24470.1

PTM databases

iPTMnetiQ6LA42

Proteomic databases

PaxDbiQ6LA42

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G24470.1; AT5G24470.1; AT5G24470
GeneIDi832518
GrameneiAT5G24470.1; AT5G24470.1; AT5G24470
KEGGiath:AT5G24470

Organism-specific databases

AraportiAT5G24470

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000034018
InParanoidiQ6LA42
KOiK12130
OrthoDBiEOG093604X6
PhylomeDBiQ6LA42

Miscellaneous databases

PROiPR:Q6LA42

Gene expression databases

ExpressionAtlasiQ6LA42 baseline and differential
GenevisibleiQ6LA42 AT

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR010402 CCT_domain
IPR011006 CheY-like_superfamily
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF06203 CCT, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51017 CCT, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPRR5_ARATH
AccessioniPrimary (citable) accession number: Q6LA42
Secondary accession number(s): F4KH52, Q9FGE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: October 10, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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