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Entry version 130 (12 Aug 2020)
Sequence version 2 (27 Sep 2004)
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Protein

Two-component response regulator-like APRR5

Gene

APRR5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. With RVE8, forms a negative feedback loop of the circadian clock (PubMed:21483796). Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Negative regulator of shade avoidance response. Involved in the inhibition of leaf expansion in shade avoidance response.6 Publications

Miscellaneous

The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock.1 Publication

Caution

Lacks the phospho-accepting Asp (here Glu-102), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms, Transcription, Transcription regulation, Two-component regulatory system

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Two-component response regulator-like APRR5
Alternative name(s):
Pseudo-response regulator 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APRR5
Ordered Locus Names:At5g24470
ORF Names:T31K7.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G24470

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000814371 – 558Two-component response regulator-like APRR5Add BLAST558

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation varies throughout the diurnal cycle and enhances ADO1 binding.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6LA42

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
244453

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6LA42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6LA42, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6LA42, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADO1 and ADO2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
17793, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q6LA42, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6LA42

STRING: functional protein association networks

More...
STRINGi
3702.AT5G24470.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6LA42

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 169Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini509 – 551CCTPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARR-like family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1601, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015512_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6LA42

KEGG Orthology (KO)

More...
KOi
K12130

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERPTLWH

Database of Orthologous Groups

More...
OrthoDBi
926211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6LA42

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00156, REC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010402, CCT_domain
IPR011006, CheY-like_superfamily
IPR001789, Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06203, CCT, 1 hit
PF00072, Response_reg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52172, SSF52172, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51017, CCT, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6LA42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSEEVVEV TVVKAPEAGG GKLSRRKIRK KDAGVDGLVK WERFLPKIAL
60 70 80 90 100
RVLLVEADDS TRQIIAALLR KCSYRVAAVP DGLKAWEMLK GKPESVDLIL
110 120 130 140 150
TEVDLPSISG YALLTLIMEH DICKNIPVIM MSTQDSVNTV YKCMLKGAAD
160 170 180 190 200
YLVKPLRRNE LRNLWQHVWR RQTSLAPDSF PWNESVGQQK AEGASANNSN
210 220 230 240 250
GKRDDHVVSG NGGDAQSSCT RPEMEGESAD VEVSARDAVQ MECAKSQFNE
260 270 280 290 300
TRLLANELQS KQAEAIDFMG ASFRRTGRRN REESVAQYES RIELDLSLRR
310 320 330 340 350
PNASENQSSG DRPSLHPSSA SAFTRYVHRP LQTQCSASPV VTDQRKNVAA
360 370 380 390 400
SQDDNIVLMN QYNTSEPPPN APRRNDTSFY TGADSPGPPF SNQLNSWPGQ
410 420 430 440 450
SSYPTPTPIN NIQFRDPNTA YTSAMAPASL SPSPSSVSPH EYSSMFHPFN
460 470 480 490 500
SKPEGLQDRD CSMDVDERRY VSSATEHSAI GNHIDQLIEK KNEDGYSLSV
510 520 530 540 550
GKIQQSLQRE AALTKFRMKR KDRCYEKKVR YESRKKLAEQ RPRIKGQFVR

QVQSTQAP
Length:558
Mass (Da):62,301
Last modified:September 27, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9813089FA9DC8CE9
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13743 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046955 mRNA Translation: BAB13743.1 Different initiation.
AB025641 Genomic DNA Translation: BAB08930.1
CP002688 Genomic DNA Translation: AED93314.2
AY062114 mRNA Translation: AAL32986.1
AY143934 mRNA Translation: AAN28873.1

NCBI Reference Sequences

More...
RefSeqi
NP_568446.2, NM_122355.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G24470.1; AT5G24470.1; AT5G24470

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
832518

Gramene; a comparative resource for plants

More...
Gramenei
AT5G24470.1; AT5G24470.1; AT5G24470

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G24470

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046955 mRNA Translation: BAB13743.1 Different initiation.
AB025641 Genomic DNA Translation: BAB08930.1
CP002688 Genomic DNA Translation: AED93314.2
AY062114 mRNA Translation: AAL32986.1
AY143934 mRNA Translation: AAN28873.1
RefSeqiNP_568446.2, NM_122355.4

3D structure databases

SMRiQ6LA42
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi17793, 28 interactors
IntActiQ6LA42, 3 interactors
MINTiQ6LA42
STRINGi3702.AT5G24470.1

PTM databases

iPTMnetiQ6LA42

Proteomic databases

PaxDbiQ6LA42
ProteomicsDBi244453

Genome annotation databases

EnsemblPlantsiAT5G24470.1; AT5G24470.1; AT5G24470
GeneIDi832518
GrameneiAT5G24470.1; AT5G24470.1; AT5G24470
KEGGiath:AT5G24470

Organism-specific databases

AraportiAT5G24470

Phylogenomic databases

eggNOGiKOG1601, Eukaryota
HOGENOMiCLU_015512_2_0_1
InParanoidiQ6LA42
KOiK12130
OMAiERPTLWH
OrthoDBi926211at2759
PhylomeDBiQ6LA42

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6LA42

Gene expression databases

ExpressionAtlasiQ6LA42, baseline and differential
GenevisibleiQ6LA42, AT

Family and domain databases

CDDicd00156, REC, 1 hit
InterProiView protein in InterPro
IPR010402, CCT_domain
IPR011006, CheY-like_superfamily
IPR001789, Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF06203, CCT, 1 hit
PF00072, Response_reg, 1 hit
SMARTiView protein in SMART
SM00448, REC, 1 hit
SUPFAMiSSF52172, SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51017, CCT, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPRR5_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6LA42
Secondary accession number(s): F4KH52, Q9FGE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: August 12, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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