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Entry version 108 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Keratin-associated protein 5-6

Gene

KRTAP5-6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6L8G9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 5-6
Alternative name(s):
Keratin-associated protein 5.6
Ultrahigh sulfur keratin-associated protein 5.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP5-6
Synonyms:KAP5.6, KRTAP5.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205864.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23600, KRTAP5-6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6L8G9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000205864

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134922071

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6L8G9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP5-6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001841041 – 129Keratin-associated protein 5-6Add BLAST129

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6L8G9

PeptideAtlas

More...
PeptideAtlasi
Q6L8G9

PRoteomics IDEntifications database

More...
PRIDEi
Q6L8G9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66551

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6L8G9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6L8G9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hair root and not in skin. Expressed also in liver and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205864, Expressed in right lobe of liver and 25 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205864, Group enriched (liver, placenta, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6L8G9
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]3EBI-10250562,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-10250562,EBI-10173507
C22orf39 [Q6P5X5]3EBI-10250562,EBI-7317823
CATSPER1 [Q8NEC5]6EBI-10250562,EBI-744545
CCN3 [P48745]3EBI-10250562,EBI-3904822
COL8A1 [P27658]3EBI-10250562,EBI-747133
CRCT1 [Q9UGL9]6EBI-10250562,EBI-713677
CREB5 - isoform 3 [Q02930-3]6EBI-10250562,EBI-10192698
CYSRT1 [A8MQ03]6EBI-10250562,EBI-3867333
DDIT4L [Q96D03]3EBI-10250562,EBI-742054
GLRX3 [O76003]7EBI-10250562,EBI-374781
GUCD1 - isoform 2 [Q96NT3-2]3EBI-10250562,EBI-11978177
HOXA1 [P49639]9EBI-10250562,EBI-740785
INCA1 [Q0VD86]3EBI-10250562,EBI-6509505
KRT31 [Q15323]3EBI-10250562,EBI-948001
KRTAP1-1 [Q07627]3EBI-10250562,EBI-11959885
KRTAP1-5 [Q9BYS1]3EBI-10250562,EBI-11741292
KRTAP10-5 [P60370]3EBI-10250562,EBI-10172150
KRTAP10-7 [P60409]6EBI-10250562,EBI-10172290
KRTAP10-8 [P60410]8EBI-10250562,EBI-10171774
KRTAP10-9 [P60411]3EBI-10250562,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-10250562,EBI-1052037
KRTAP12-1 [P59990]3EBI-10250562,EBI-10210845
KRTAP12-3 [P60328]3EBI-10250562,EBI-11953334
KRTAP13-3 [Q3SY46]3EBI-10250562,EBI-10241252
KRTAP17-1 [Q9BYP8]5EBI-10250562,EBI-11988175
KRTAP26-1 [Q6PEX3]6EBI-10250562,EBI-3957672
KRTAP3-3 [Q9BYR6]3EBI-10250562,EBI-3957694
KRTAP4-1 [A0A087WY89]3EBI-10250562,EBI-11957260
KRTAP4-11 [Q9BYQ6]3EBI-10250562,EBI-10302392
KRTAP4-12 [Q9BQ66]6EBI-10250562,EBI-739863
KRTAP4-2 [Q9BYR5]8EBI-10250562,EBI-10172511
KRTAP5-1 [Q6L8H4]3EBI-10250562,EBI-12074540
KRTAP5-7 [Q6L8G8]4EBI-10250562,EBI-11987425
KRTAP5-9 [P26371]9EBI-10250562,EBI-3958099
KRTAP9-2 [Q9BYQ4]8EBI-10250562,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-10250562,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-10250562,EBI-10185730
KRTAP9-8 [Q9BYQ0]4EBI-10250562,EBI-11958364
LBX1 [P52954]3EBI-10250562,EBI-20141748
LCE1A [Q5T7P2]3EBI-10250562,EBI-11962058
LCE1B [Q5T7P3]5EBI-10250562,EBI-10245913
LCE1C [Q5T751]3EBI-10250562,EBI-12224199
LCE1D [Q5T752]6EBI-10250562,EBI-11741311
LCE1E [Q5T753]3EBI-10250562,EBI-11955335
LCE1F [Q5T754]3EBI-10250562,EBI-11958008
LCE2A [Q5TA79]3EBI-10250562,EBI-10246607
LCE2C [Q5TA81]6EBI-10250562,EBI-11973993
LCE2D [Q5TA82]3EBI-10250562,EBI-10246750
LCE3A [Q5TA76]6EBI-10250562,EBI-9394625
LCE3B [Q5TA77]3EBI-10250562,EBI-11974495
LCE3C [Q5T5A8]3EBI-10250562,EBI-10245291
LCE3D [Q9BYE3]3EBI-10250562,EBI-6658837
LCE3E [Q5T5B0]3EBI-10250562,EBI-10245456
LCE4A [Q5TA78]3EBI-10250562,EBI-10246358
LCE5A [Q5TCM9]5EBI-10250562,EBI-11955689
LELP1 [Q5T871]3EBI-10250562,EBI-18115868
LINGO1 [Q96FE5]3EBI-10250562,EBI-719955
LMNTD2 [Q8IXW0]3EBI-10250562,EBI-12028858
MAPKBP1 [O60336]3EBI-10250562,EBI-947402
MEOX2 [P50222]3EBI-10250562,EBI-748397
MEOX2 [Q6FHY5]3EBI-10250562,EBI-16439278
MYPOP [Q86VE0]3EBI-10250562,EBI-2858213
NLK [Q9UBE8]3EBI-10250562,EBI-366978
NOTCH2NLA [Q7Z3S9]4EBI-10250562,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-10250562,EBI-22310682
NOTO [A8MTQ0]3EBI-10250562,EBI-17490746
NR1D2 [Q6NSM0]3EBI-10250562,EBI-10250949
NR4A3 [Q92570]3EBI-10250562,EBI-13644623
NUFIP2 [Q7Z417]6EBI-10250562,EBI-1210753
OTX1 [P32242]6EBI-10250562,EBI-740446
OXER1 [Q8TDS5]3EBI-10250562,EBI-12813389
PLSCR1 [O15162]3EBI-10250562,EBI-740019
POU4F2 [Q12837]3EBI-10250562,EBI-17236143
RGS17 [Q9UGC6]3EBI-10250562,EBI-3918154
RGS19 [P49795]3EBI-10250562,EBI-874907
RGS20 - isoform 5 [O76081-6]6EBI-10250562,EBI-10178530
SMCP [P49901]8EBI-10250562,EBI-750494
SPRY2 [O43597]3EBI-10250562,EBI-742487
VGLL3 - isoform 2 [A8MV65-2]3EBI-10250562,EBI-11957216
YY1 [P25490]3EBI-10250562,EBI-765538

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
136221, 79 interactors

Protein interaction database and analysis system

More...
IntActi
Q6L8G9, 81 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371595

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6L8G9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 3114
Repeati34 – 3724
Repeati40 – 4334
Repeati90 – 9344
Repeati109 – 11254
Repeati119 – 12264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 1126 X 4 AA repeats of C-C-X-PAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TEXH, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164776

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_097966_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CWGCTGS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6L8G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCTSC
60 70 80 90 100
GSCGGSKGCC GSCGGSKGGC GSCGGSKGGC GSCGCSQCSC CKPCYCSSGC
110 120
GSSCCQSSCC KPCCSQASCC VPICCQCKI
Length:129
Mass (Da):11,784
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C19C560119E2C3F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0621556C → F. Corresponds to variant dbSNP:rs58645950Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB126075 mRNA Translation: BAD20202.1
BC130399 mRNA Translation: AAI30400.1
BC133035 mRNA Translation: AAI33036.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31332.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012416.1, NM_001012416.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382160; ENSP00000371595; ENSG00000205864
ENST00000611731; ENSP00000479098; ENSG00000277389

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
440023

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440023

UCSC genome browser

More...
UCSCi
uc001lua.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126075 mRNA Translation: BAD20202.1
BC130399 mRNA Translation: AAI30400.1
BC133035 mRNA Translation: AAI33036.1
CCDSiCCDS31332.1
RefSeqiNP_001012416.1, NM_001012416.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi136221, 79 interactors
IntActiQ6L8G9, 81 interactors
STRINGi9606.ENSP00000371595

PTM databases

iPTMnetiQ6L8G9
PhosphoSitePlusiQ6L8G9

Polymorphism and mutation databases

BioMutaiKRTAP5-6

Proteomic databases

PaxDbiQ6L8G9
PeptideAtlasiQ6L8G9
PRIDEiQ6L8G9
ProteomicsDBi66551

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
440023

Genome annotation databases

EnsembliENST00000382160; ENSP00000371595; ENSG00000205864
ENST00000611731; ENSP00000479098; ENSG00000277389
GeneIDi440023
KEGGihsa:440023
UCSCiuc001lua.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440023
EuPathDBiHostDB:ENSG00000205864.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP5-6
HGNCiHGNC:23600, KRTAP5-6
HPAiENSG00000205864, Group enriched (liver, placenta, skin)
neXtProtiNX_Q6L8G9
OpenTargetsiENSG00000205864
PharmGKBiPA134922071

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TEXH, Eukaryota
GeneTreeiENSGT00940000164776
HOGENOMiCLU_097966_1_0_1
OMAiCWGCTGS

Enzyme and pathway databases

PathwayCommonsiQ6L8G9
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
440023, 307 hits in 839 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
440023
PharosiQ6L8G9, Tdark

Protein Ontology

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PROi
PR:Q6L8G9
RNActiQ6L8G9, protein

Gene expression databases

BgeeiENSG00000205864, Expressed in right lobe of liver and 25 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA56_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6L8G9
Secondary accession number(s): A1L452
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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