UniProtKB - Q6L8G4 (KR511_HUMAN)
Protein
Keratin-associated protein 5-11
Gene
KRTAP5-11
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Biological processi
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q6L8G4 |
Reactomei | R-HSA-6805567, Keratinization |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 5-11Alternative name(s): Keratin-associated protein 5.11 Ultrahigh sulfur keratin-associated protein 5.11 |
Gene namesi | Name:KRTAP5-11 Synonyms:KAP5.11, KRTAP5.11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23606, KRTAP5-11 |
neXtProti | NX_Q6L8G4 |
VEuPathDBi | HostDB:ENSG00000204571.5 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: InterPro
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204571 |
PharmGKBi | PA134989436 |
Miscellaneous databases
Pharosi | Q6L8G4, Tdark |
Genetic variation databases
BioMutai | KRTAP5-11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184109 | 1 – 156 | Keratin-associated protein 5-11Add BLAST | 156 |
Proteomic databases
PaxDbi | Q6L8G4 |
PeptideAtlasi | Q6L8G4 |
PRIDEi | Q6L8G4 |
ProteomicsDBi | 66548 |
PTM databases
iPTMneti | Q6L8G4 |
PhosphoSitePlusi | Q6L8G4 |
Expressioni
Tissue specificityi
Restricted to hair root, not detected in any other tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000204571, Expressed in putamen and 33 other tissues |
ExpressionAtlasi | Q6L8G4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000204571, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Q6L8G4
Protein-protein interaction databases
BioGRIDi | 136248, 58 interactors |
IntActi | Q6L8G4, 55 interactors |
STRINGi | 9606.ENSP00000381541 |
Miscellaneous databases
RNActi | Q6L8G4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 35 – 38 | 1 | 4 | |
Repeati | 41 – 44 | 2 | 4 | |
Repeati | 47 – 50 | 3 | 4 | |
Repeati | 87 – 90 | 4 | 4 | |
Repeati | 121 – 124 | 5 | 4 | |
Repeati | 146 – 149 | 6 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 149 | 6 X 4 AA repeats of C-C-X-PAdd BLAST | 115 |
Sequence similaritiesi
Belongs to the KRTAP type 5 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502TE7N, Eukaryota |
GeneTreei | ENSGT00950000184990 |
HOGENOMi | CLU_097966_1_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 1 hit |
Pfami | View protein in Pfam PF13885, Keratin_B2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6L8G4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCCGCSGGC GSGCGGCGSG SGGCGSGCGG CGSSCCVPIC CCKPVCCCVP
60 70 80 90 100
ACSCSSCGSC GGSKGGCGSC GSSKGGCGSC GCSQSNCCKP CCSSSGCGSF
110 120 130 140 150
CCQSSCSKPC CCQSSCCQSS CCKPCCCQSS CCQSSCFKPC CCQSSCCVPV
CCQCKI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WXQ9 | A0A087WXQ9_HUMAN | Keratin-associated protein 5-11 | KRTAP5-11 | 185 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB126080 mRNA Translation: BAD20207.1 |
CCDSi | CCDS41685.1 |
RefSeqi | NP_001005405.1, NM_001005405.2 |
Genome annotation databases
Ensembli | ENST00000398530; ENSP00000381541; ENSG00000204571 |
GeneIDi | 440051 |
KEGGi | hsa:440051 |
UCSCi | uc001oqu.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB126080 mRNA Translation: BAD20207.1 |
CCDSi | CCDS41685.1 |
RefSeqi | NP_001005405.1, NM_001005405.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 136248, 58 interactors |
IntActi | Q6L8G4, 55 interactors |
STRINGi | 9606.ENSP00000381541 |
PTM databases
iPTMneti | Q6L8G4 |
PhosphoSitePlusi | Q6L8G4 |
Genetic variation databases
BioMutai | KRTAP5-11 |
Proteomic databases
PaxDbi | Q6L8G4 |
PeptideAtlasi | Q6L8G4 |
PRIDEi | Q6L8G4 |
ProteomicsDBi | 66548 |
Protocols and materials databases
Antibodypediai | 77334, 1 antibodies |
DNASUi | 440051 |
Genome annotation databases
Ensembli | ENST00000398530; ENSP00000381541; ENSG00000204571 |
GeneIDi | 440051 |
KEGGi | hsa:440051 |
UCSCi | uc001oqu.3, human |
Organism-specific databases
CTDi | 440051 |
GeneCardsi | KRTAP5-11 |
HGNCi | HGNC:23606, KRTAP5-11 |
HPAi | ENSG00000204571, Tissue enriched (skin) |
neXtProti | NX_Q6L8G4 |
OpenTargetsi | ENSG00000204571 |
PharmGKBi | PA134989436 |
VEuPathDBi | HostDB:ENSG00000204571.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TE7N, Eukaryota |
GeneTreei | ENSGT00950000184990 |
HOGENOMi | CLU_097966_1_0_1 |
Enzyme and pathway databases
PathwayCommonsi | Q6L8G4 |
Reactomei | R-HSA-6805567, Keratinization |
Miscellaneous databases
BioGRID-ORCSi | 440051, 275 hits in 846 CRISPR screens |
ChiTaRSi | KRTAP5-11, human |
GenomeRNAii | 440051 |
Pharosi | Q6L8G4, Tdark |
PROi | PR:Q6L8G4 |
RNActi | Q6L8G4, protein |
Gene expression databases
Bgeei | ENSG00000204571, Expressed in putamen and 33 other tissues |
ExpressionAtlasi | Q6L8G4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 1 hit |
Pfami | View protein in Pfam PF13885, Keratin_B2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KR511_HUMAN | |
Accessioni | Q6L8G4Primary (citable) accession number: Q6L8G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families