Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase II large subunit

Gene

polC

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciPTOR263820:G1G0U-601-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:PTO0558
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002946991 – 1080DNA polymerase II large subunitAdd BLAST1080

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0558

Structurei

3D structure databases

SMRiQ6L1K9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447 Archaea
COG1933 LUCA
HOGENOMiHOG000286435
KOiK02322
OMAiKRRNCDG
OrthoDBiPOG093Z06CT

Family and domain databases

HAMAPiMF_00324 DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475 PolC_DP2
IPR016033 PolC_DP2_N
PANTHERiPTHR42210 PTHR42210, 2 hits
PfamiView protein in Pfam
PF03833 PolC_DP2, 1 hit
PIRSFiPIRSF016275 PolC_DP2, 1 hit
TIGRFAMsiTIGR00354 polC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L1K9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDHSLFDYN ERLRKETYEC YEIAKKARAM GLDVSDEVEI PIANDMAERV
60 70 80 90 100
EELIHISGIA GEIRELSKSM SREELSLHIS KKVASLLKDN RVEALDKAVR
110 120 130 140 150
VGLAILTEGI LVAPLEGIKD VKINKNDDGT EYVSIVYSGP IRSAGGTAQA
160 170 180 190 200
LSVLIADIVR RELNIGSFSP TDDEIERYIE EVEAYNRLKH LQYMPTPDEI
210 220 230 240 250
RLVLKNSPVM IDGEGSEEEE VSGHRDMKRI TTNRIRGGMC LVLCEGLIQK
260 270 280 290 300
AKKVLKYTNV MHLNEWNILE NIGKNKSDEK TENKSEKYLK DIIAGRPVFG
310 320 330 340 350
YPNRPGGFRL RYGRSRVSGL AAASINPVTM KILNDFIAIG SQIKVELPGK
360 370 380 390 400
AAAITPCDSI DGPMVLTRSG DHIKVKSIEQ AEKIKNDIER ITDLGEILIA
410 420 430 440 450
YGDFLENNRN LDLSPFTREW WEYYLNDELS IYKSRDPDQF DAVNISRKYK
460 470 480 490 500
MPMFPGYDYF WHDITMEELN LLINAIANGI INDDSMMLDA SVSEILIKLG
510 520 530 540 550
IEFKKHNNKL ILHEYYPLIV SCGFDLINEK IVKVSDERKN DVLGTVNALS
560 570 580 590 600
GIEIKPRAPV RVGARLGRPE KAGDRKMKPK VHGLFPLMNY GGSTRSIINA
610 620 630 640 650
ARSGSIMDIE LGARICRACG TETPFVRCPK CGMPTEDSDS EKKFKIDISK
660 670 680 690 700
ALDDAALRVS TDIGTIKELK GVKKLMSRRS VIEPLEKAIL RAKHGISINK
710 720 730 740 750
DGTCRYDMSD IPITHFKYNE ISLTRQRLME LGYSDSDINE IYPQDIIIPR
760 770 780 790 800
DAASYLLNVS KFIDDLLVNY YGLGPYYMCN SEDDLIGHLV IGLAPHTSGG
810 820 830 840 850
IVGRIIGFSD VNGCYAHPFF HAAKRRNCDG DEDSIMLLLD GLLNFSKKYL
860 870 880 890 900
PSTTGGLMDA PLVLTLILDP EEIDKEALNV DTLQRYPLDF YIATEKNAPP
910 920 930 940 950
ASIENMMKTM KVLIKDGRYT GISYSFDTGD ISYGTRLSAY KTIGSMEEKI
960 970 980 990 1000
EKQLGLARIL RSVDENDVAA RVLSSHFLPD IYGNFRSFFT QEFRCTKCNA
1010 1020 1030 1040 1050
KYRRVPLSGR CLRCGSSNII LTIHHGSIVK YLNETKKVMN EYKLPDYLVF
1060 1070 1080
RINRLLEQIE STFDIENGND TTLDALIENE
Length:1,080
Mass (Da):121,576
Last modified:July 5, 2004 - v1
Checksum:i02273EA4918062BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA Translation: AAT43143.1
RefSeqiWP_011177359.1, NC_005877.1

Genome annotation databases

EnsemblBacteriaiAAT43143; AAT43143; PTO0558
GeneIDi2844296
KEGGipto:PTO0558
PATRICifig|263820.9.peg.587

Similar proteinsi

Entry informationi

Entry nameiDP2L_PICTO
AccessioniPrimary (citable) accession number: Q6L1K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again