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Entry version 167 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

SLC25A25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.23.1 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Mitochondrial ATP-Mg/Pi carrier protein 3
Mitochondrial Ca(2+)-dependent solute carrier protein 3
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A25
Synonyms:APC3, KIAA1896, MCSC3, SCAMC2
ORF Names:UNQ549/PRO1106
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20663 SLC25A25

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608745 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6KCM7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 189Mitochondrial intermembraneSequence analysisAdd BLAST189
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 244Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei245 – 264Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini265 – 287Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei288 – 301Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini302 – 337Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei338 – 357Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini358 – 380Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini399 – 437Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei438 – 457Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini458 – 469Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952319

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A25

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758042

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176021 – 469Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST469

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6KCM7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6KCM7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6KCM7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6KCM7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6KCM7

PeptideAtlas

More...
PeptideAtlasi
Q6KCM7

PRoteomics IDEntifications database

More...
PRIDEi
Q6KCM7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66541 [Q6KCM7-1]
66542 [Q6KCM7-2]
66543 [Q6KCM7-3]
66544 [Q6KCM7-4]
66545 [Q6KCM7-5]
66546 [Q6KCM7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6KCM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6KCM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148339 Expressed in 198 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6KCM7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6KCM7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125351, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q6KCM7, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362159

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6KCM7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 149EF-hand 3PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati184 – 270Solcar 1Add BLAST87
Repeati278 – 363Solcar 2Add BLAST86
Repeati375 – 463Solcar 3Add BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0036 Eukaryota
ENOG410XQ4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157207

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6KCM7

KEGG Orthology (KO)

More...
KOi
K14684

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEYSSRA

Database of Orthologous Groups

More...
OrthoDBi
442523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6KCM7

TreeFam database of animal gene trees

More...
TreeFami
TF313492

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
PF00153 Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00928 GRAVESDC
PR00926 MITOCARRIER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6KCM7-1) [UniParc]FASTAAdd to basket
Also known as: SCaMC-2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCLCLYVPV IGEAQTEFQY FESKGLPAEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMGIVGGF TQMIREGGAR SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQIKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCARRILARE GVAAFYKGYV PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNAWLQHYAV NSADPGVFVL LACGTMSSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKHILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,663
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA50825AA95DBD4BE
GO
Isoform 2 (identifier: Q6KCM7-2) [UniParc]FASTAAdd to basket
Also known as: SCaMC-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLCLCLYVPV...QEFSTYRQWK → MVSSVLCRCV...LGLHRTEGEL

Show »
Length:503
Mass (Da):55,398
Checksum:i01F0C668941DA37F
GO
Isoform 3 (identifier: Q6KCM7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLCLCLYVPV...QEFSTYRQWK → MVSSVLCRCV...LGLHRTEGEL
     125-125: S → RIRTGHFWGPVTY

Show »
Length:515
Mass (Da):56,883
Checksum:iF7549BDE9AB03F09
GO
Isoform 4 (identifier: Q6KCM7-4) [UniParc]FASTAAdd to basket
Also known as: SCaMC-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPV...EFSTYRQWKQ → MLQMLWHFLA...VVGPAEQFPK

Show »
Length:489
Mass (Da):54,638
Checksum:i1BD8AAB1C40592DB
GO
Isoform 5 (identifier: Q6KCM7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPV...EFSTYRQWKQ → MLQMLWHFLA...VVGPAEQFPK
     125-125: S → RIRTGHFWGPVTY

Show »
Length:501
Mass (Da):56,123
Checksum:i9F5ADEE4BB6BEEEA
GO
Isoform 6 (identifier: Q6KCM7-6) [UniParc]FASTAAdd to basket
Also known as: SCaMC-2d

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:366
Mass (Da):40,589
Checksum:iC02E524BE6120F90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4Z4H7C4Z4_HUMAN
Calcium-binding mitochondrial carri...
SLC25A25
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEY9F8WEY9_HUMAN
Calcium-binding mitochondrial carri...
SLC25A25
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB67789 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89S → I in AAQ88879 (PubMed:12975309).Curated1
Sequence conflicti162T → Q in AAH05163 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310671 – 103Missing in isoform 6. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_0310681 – 53MLCLC…RQWKQ → MLQMLWHFLASFFPRAGCHG SREGDDREVRGTPAPAWRDQ MASFLGKQDGRAEATEKRPT ILLVVGPAEQFPK in isoform 4 and isoform 5. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_0310691 – 52MLCLC…YRQWK → MVSSVLCRCVASPPPDAAAT AASSSASSPASVGDPCGGAI CGGPDHRLRLWRLFQTLDVN RDGGLCVNDLAVGLRRLGLH RTEGEL in isoform 2 and isoform 3. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_031070125S → RIRTGHFWGPVTY in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ619989 mRNA Translation: CAF04495.1
AJ619990 mRNA Translation: CAF04496.1
AJ619991 mRNA Translation: CAF04497.1
AJ619992 mRNA Translation: CAF04498.1
AJ619963 mRNA Translation: CAF04060.1
AB067483 mRNA Translation: BAB67789.1 Different initiation.
AY358515 mRNA Translation: AAQ88879.1
AK290705 mRNA Translation: BAF83394.1
AK290991 mRNA Translation: BAF83680.1
CH471090 Genomic DNA Translation: EAW87739.1
AL360268 Genomic DNA No translation available.
AL590708 Genomic DNA No translation available.
BC005163 mRNA Translation: AAH05163.2
BC089448 mRNA Translation: AAH89448.1
BC103930 mRNA Translation: AAI03931.1
BC103931 mRNA Translation: AAI03932.1
BC103932 mRNA Translation: AAI03933.1
BC103933 mRNA Translation: AAI03934.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35151.1 [Q6KCM7-2]
CCDS48031.1 [Q6KCM7-4]
CCDS59146.1 [Q6KCM7-5]
CCDS6890.1 [Q6KCM7-1]
CCDS83420.1 [Q6KCM7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001006642.1, NM_001006641.3 [Q6KCM7-2]
NP_001006643.1, NM_001006642.3 [Q6KCM7-4]
NP_001252543.1, NM_001265614.2 [Q6KCM7-5]
NP_001317917.1, NM_001330988.1 [Q6KCM7-3]
NP_443133.2, NM_052901.4 [Q6KCM7-1]
XP_005251746.1, XM_005251689.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373064; ENSP00000362155; ENSG00000148339 [Q6KCM7-1]
ENST00000373066; ENSP00000362157; ENSG00000148339 [Q6KCM7-5]
ENST00000373068; ENSP00000362159; ENSG00000148339 [Q6KCM7-2]
ENST00000373069; ENSP00000362160; ENSG00000148339 [Q6KCM7-3]
ENST00000432073; ENSP00000410053; ENSG00000148339 [Q6KCM7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114789

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114789

UCSC genome browser

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UCSCi
uc004btb.5 human [Q6KCM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619989 mRNA Translation: CAF04495.1
AJ619990 mRNA Translation: CAF04496.1
AJ619991 mRNA Translation: CAF04497.1
AJ619992 mRNA Translation: CAF04498.1
AJ619963 mRNA Translation: CAF04060.1
AB067483 mRNA Translation: BAB67789.1 Different initiation.
AY358515 mRNA Translation: AAQ88879.1
AK290705 mRNA Translation: BAF83394.1
AK290991 mRNA Translation: BAF83680.1
CH471090 Genomic DNA Translation: EAW87739.1
AL360268 Genomic DNA No translation available.
AL590708 Genomic DNA No translation available.
BC005163 mRNA Translation: AAH05163.2
BC089448 mRNA Translation: AAH89448.1
BC103930 mRNA Translation: AAI03931.1
BC103931 mRNA Translation: AAI03932.1
BC103932 mRNA Translation: AAI03933.1
BC103933 mRNA Translation: AAI03934.1
CCDSiCCDS35151.1 [Q6KCM7-2]
CCDS48031.1 [Q6KCM7-4]
CCDS59146.1 [Q6KCM7-5]
CCDS6890.1 [Q6KCM7-1]
CCDS83420.1 [Q6KCM7-3]
RefSeqiNP_001006642.1, NM_001006641.3 [Q6KCM7-2]
NP_001006643.1, NM_001006642.3 [Q6KCM7-4]
NP_001252543.1, NM_001265614.2 [Q6KCM7-5]
NP_001317917.1, NM_001330988.1 [Q6KCM7-3]
NP_443133.2, NM_052901.4 [Q6KCM7-1]
XP_005251746.1, XM_005251689.4

3D structure databases

SMRiQ6KCM7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125351, 16 interactors
IntActiQ6KCM7, 15 interactors
STRINGi9606.ENSP00000362159

Protein family/group databases

TCDBi2.A.29.23.1 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ6KCM7
PhosphoSitePlusiQ6KCM7

Polymorphism and mutation databases

BioMutaiSLC25A25
DMDMi74758042

Proteomic databases

EPDiQ6KCM7
jPOSTiQ6KCM7
MassIVEiQ6KCM7
MaxQBiQ6KCM7
PaxDbiQ6KCM7
PeptideAtlasiQ6KCM7
PRIDEiQ6KCM7
ProteomicsDBi66541 [Q6KCM7-1]
66542 [Q6KCM7-2]
66543 [Q6KCM7-3]
66544 [Q6KCM7-4]
66545 [Q6KCM7-5]
66546 [Q6KCM7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373064; ENSP00000362155; ENSG00000148339 [Q6KCM7-1]
ENST00000373066; ENSP00000362157; ENSG00000148339 [Q6KCM7-5]
ENST00000373068; ENSP00000362159; ENSG00000148339 [Q6KCM7-2]
ENST00000373069; ENSP00000362160; ENSG00000148339 [Q6KCM7-3]
ENST00000432073; ENSP00000410053; ENSG00000148339 [Q6KCM7-4]
GeneIDi114789
KEGGihsa:114789
UCSCiuc004btb.5 human [Q6KCM7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114789

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC25A25
HGNCiHGNC:20663 SLC25A25
HPAiHPA020381
MIMi608745 gene
neXtProtiNX_Q6KCM7
OpenTargetsiENSG00000148339
PharmGKBiPA134952319

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00940000157207
InParanoidiQ6KCM7
KOiK14684
OMAiYEYSSRA
OrthoDBi442523at2759
PhylomeDBiQ6KCM7
TreeFamiTF313492

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC25A25 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114789

Pharos

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Pharosi
Q6KCM7

Protein Ontology

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PROi
PR:Q6KCM7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148339 Expressed in 198 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ6KCM7 baseline and differential
GenevisibleiQ6KCM7 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCMC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6KCM7
Secondary accession number(s): Q5SYW7
, Q5SYW8, Q5SYX3, Q5VWU2, Q5VWU3, Q5VWU4, Q6KCM4, Q6KCM6, Q6UX48, Q705K2, Q96PZ1, Q9BSA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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