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Entry version 137 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Nipped-B-like protein

Gene

Nipbl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the loading of the cohesin complex on to DNA (PubMed:29094699). Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2470946 Cohesin Loading onto Chromatin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nipped-B-like protein
Alternative name(s):
Delangin homolog
SCC2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nipbl
Synonyms:Scc21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1913976 Nipbl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion of NIPBL in mouse liver leads to strong depletion of chromatin-bound cohesin and marked reorganization of chromosomal folding. Cells retain transcriptionally active (type A) and transcriptionally inactive (type B) compartments, but lose topologically associating domains (TADs) patterns and TAD-associated peaks of contact enrichment across the whole genome. The compartmentalization of chromatin in cells lacking NIPBL is enhanced around 1.8-fold compared with controls.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002185971 – 2798Nipped-B-like proteinAdd BLAST2798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei150PhosphoserineCombined sources1
Modified residuei162PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei256PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei350PhosphoserineBy similarity1
Modified residuei713PhosphothreonineBy similarity1
Modified residuei746PhosphothreonineBy similarity1
Modified residuei906PhosphoserineBy similarity1
Modified residuei1076N6-acetyllysineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1084PhosphoserineCombined sources1
Modified residuei1090PhosphoserineCombined sources1
Modified residuei1144PhosphoserineCombined sources1
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1153PhosphotyrosineCombined sources1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1183PhosphothreonineBy similarity1
Modified residuei1191PhosphoserineBy similarity1
Modified residuei2487PhosphoserineCombined sources1
Modified residuei2503PhosphoserineCombined sources1
Modified residuei2505PhosphoserineCombined sources1
Modified residuei2507PhosphoserineCombined sources1
Modified residuei2509PhosphoserineBy similarity1
Modified residuei2646PhosphoserineBy similarity1
Modified residuei2652PhosphoserineCombined sources1
Modified residuei2661PhosphothreonineCombined sources1
Modified residuei2666PhosphoserineCombined sources1
Isoform 2 (identifier: Q6KCD5-2)
Modified residuei2661PhosphothreonineCombined sources1
Modified residuei2666PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6KCD5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6KCD5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6KCD5

PeptideAtlas

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PeptideAtlasi
Q6KCD5

PRoteomics IDEntifications database

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PRIDEi
Q6KCD5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6KCD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6KCD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Spermatocytes and oocytes (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed at 9.5 and 10.5 dpc, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face. Expressed in the developing brain, with enrichment in the ventricular zone at 14.5 dpc (PubMed:28041881).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000022141 Expressed in 294 organ(s), highest expression level in thymus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6KCD5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimerizes with MAU2/SCC4 to form the cohesin loading complex (By similarity). The NIPBL-MAU2 heterodimer interacts with the SMC1A-SMC3 heterodimer and with the cohesin complex composed of SMC1A, SMC3, RAD21 and STAG1.

Interacts directly (via PxVxL motif) with CBX3 and CBX5 (By similarity).

Interacts with ZNF609 (via N-terminus) (PubMed:28041881).

Interacts with the multiprotein complex Integrator (PubMed:28041881).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
214531, 9 interactors

Database of interacting proteins

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DIPi
DIP-56622N

Protein interaction database and analysis system

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IntActi
Q6KCD5, 14 interactors

Molecular INTeraction database

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MINTi
Q6KCD5

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000059385

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q6KCD5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6KCD5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1761 – 1799HEAT 1Add BLAST39
Repeati1837 – 1875HEAT 2Add BLAST39
Repeati1939 – 1978HEAT 3Add BLAST40
Repeati2221 – 2261HEAT 4Add BLAST41
Repeati2307 – 2345HEAT 5Add BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi990 – 1003PxVxL motifBy similarityAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi418 – 462Gln-richAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.By similarity
The C-terminal region containing HEAT repeats and Pro-Xaa-Val-Xaa-Leu (PxVxL) motif are involved in the recruitment of NIPBL to sites of DNA damage.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1020 Eukaryota
ENOG410XP32 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000010427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113787

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6KCD5

KEGG Orthology (KO)

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KOi
K06672

Identification of Orthologs from Complete Genome Data

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OMAi
ITPQDIN

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6KCD5

TreeFam database of animal gene trees

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TreeFami
TF313121

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B

The PANTHER Classification System

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PANTHERi
PTHR21704 PTHR21704, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6KCD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV
60 70 80 90 100
NCLLACRDDN LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL
110 120 130 140 150
ARSPNVFREK SMQNRYVQSG MMMSQYKLSQ NSMHSSPASS NYQQTTISHS
160 170 180 190 200
PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP QSPAGYMPYS HPSSYTTHPQ
210 220 230 240 250
MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR HGSSDDYLHM
260 270 280 290 300
VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ
310 320 330 340 350
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS
360 370 380 390 400
PTKDSTKLTL RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT
410 420 430 440 450
SKTPITPQDV NRPLNAAQCL SQQEQTAFLP ANQVPVLQQN TSVATKQPQT
460 470 480 490 500
SVVQNQQQVS QQGPIYDEVE LDALAEIERI ERESAIERER FSKEVQDKDK
510 520 530 540 550
PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM VSIDLHQAGR
560 570 580 590 600
VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP
610 620 630 640 650
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE
660 670 680 690 700
LKQNENKTTE SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP
710 720 730 740 750
ETPKQKAESR PETPKQKSEG RPETPKQKGD GRPETPKQKS EGRPETPKQK
760 770 780 790 800
GEGRPETPKH RHENRRDSGK PSTEKKPDVS KHKQDIKSDS PRLKSERAEA
810 820 830 840 850
LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR PETLRSSSRN
860 870 880 890 900
DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS
910 920 930 940 950
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF
960 970 980 990 1000
VIPKIKRDKD GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ
1010 1020 1030 1040 1050
KLSLDDVQKL IKDREEKSRS SLKSIKNKPS KSNKGSIDQS VLKELPPELL
1060 1070 1080 1090 1100
AEIESTMPLC ERVKMNKRKR STVNEKPKYA EISSDEDNDS DEAFESSRKR
1110 1120 1130 1140 1150
HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY RNRSPSDSDM
1160 1170 1180 1190 1200
EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI
1210 1220 1230 1240 1250
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK
1260 1270 1280 1290 1300
LSTDKTVKVL NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK
1310 1320 1330 1340 1350
SADACLTTIN IMTSPNMPKA VYIEDVIERV IQYTKFHLQN TLYPQYDPVY
1360 1370 1380 1390 1400
RVDPHGGGLL SSKAKRAKCS THKQRVIVML YNKVCDIVSS LSELLEIQLL
1410 1420 1430 1440 1450
TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE KHRQLILEEI
1460 1470 1480 1490 1500
FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS
1510 1520 1530 1540 1550
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE
1560 1570 1580 1590 1600
DYRPLFENFV QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR
1610 1620 1630 1640 1650
VASLDYLGTV AARLRKDAVT SKMDQGSIER ILKQVSGGED EIQQLQKALL
1660 1670 1680 1690 1700
DYLDENTETD PSLVFSRKFY IAQWFRDTTL ETEKAMKSQK DEESSDATHH
1710 1720 1730 1740 1750
AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD TVDYDDACLI
1760 1770 1780 1790 1800
VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI
1810 1820 1830 1840 1850
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER
1860 1870 1880 1890 1900
ILDTGISVRK RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV
1910 1920 1930 1940 1950
NETFQKLWFT PTPHNDKEAM TRKILNITDV VAACRDTGYD WFEQLLQNLL
1960 1970 1980 1990 2000
KSEEDSSYKP VKKACTQLVD NLVEHILKYE ESLADSDNKG VNSGRLVACI
2010 2020 2030 2040 2050
TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN VAKILELVVP
2060 2070 2080 2090 2100
LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV
2110 2120 2130 2140 2150
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF
2160 2170 2180 2190 2200
DLEDFKGNSK VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL
2210 2220 2230 2240 2250
MFEQEVKNLY NSILSDKNSS VNLKIQVLKN LQTYLQEEDT RMQQADRDWK
2260 2270 2280 2290 2300
KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV LEAFFHTQSS VRHFALNVIA
2310 2320 2330 2340 2350
LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID KKYAGFIHMK
2360 2370 2380 2390 2400
AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR
2410 2420 2430 2440 2450
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT
2460 2470 2480 2490 2500
LSVSGSNLLQ SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR
2510 2520 2530 2540 2550
VDSESDSDSE DDINSVMKCL PENSAPLIEF ANVSQGILLL LMLKQHLKNL
2560 2570 2580 2590 2600
CGFSDSKIQK YSPSESAKVY DKAINRKTGV HFHPKQTLDF LRSDMANSKL
2610 2620 2630 2640 2650
TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR NKAITSLLGG
2660 2670 2680 2690 2700
GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD
2710 2720 2730 2740 2750
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG
2760 2770 2780 2790
RKLVPWVDTI KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS
Length:2,798
Mass (Da):315,450
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC23B6E2C949C9B3
GO
Isoform 2 (identifier: Q6KCD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
     2692-2798: Missing.

Show »
Length:2,691
Mass (Da):303,763
Checksum:i15871B1EF11857A7
GO
Isoform 3 (identifier: Q6KCD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2694: Missing.

Show »
Length:104
Mass (Da):11,598
Checksum:i48CCA6BE60A266F2
GO
Isoform 4 (identifier: Q6KCD5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
     557-2798: Missing.

Show »
Length:293
Mass (Da):32,742
Checksum:i946EB9CB53827AE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2577K → I in BAC25453 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0110941 – 2694Missing in isoform 3. 1 PublicationAdd BLAST2694
Alternative sequenceiVSP_0110951 – 263Missing in isoform 4. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_011096499 – 556DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_011097557 – 2798Missing in isoform 4. 1 PublicationAdd BLAST2242
Alternative sequenceiVSP_0110982678 – 2691SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0110992692 – 2798Missing in isoform 2. 2 PublicationsAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ627033 mRNA Translation: CAF25291.1
AJ640138 mRNA Translation: CAG26692.1
AK014915 mRNA Translation: BAC25453.1
AK016861 mRNA Translation: BAB30471.1
AK049588 mRNA Translation: BAC33829.1
BC055787 mRNA Translation: AAH55787.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37035.1 [Q6KCD5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_081983.2, NM_027707.3 [Q6KCD5-1]
NP_957684.1, NM_201232.2 [Q6KCD5-2]
XP_006520057.1, XM_006519994.3 [Q6KCD5-1]
XP_006520058.1, XM_006519995.2 [Q6KCD5-1]
XP_017172234.1, XM_017316745.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141 [Q6KCD5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71175

UCSC genome browser

More...
UCSCi
uc007veq.2 mouse [Q6KCD5-1]
uc007ver.2 mouse [Q6KCD5-2]
uc007vev.1 mouse [Q6KCD5-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627033 mRNA Translation: CAF25291.1
AJ640138 mRNA Translation: CAG26692.1
AK014915 mRNA Translation: BAC25453.1
AK016861 mRNA Translation: BAB30471.1
AK049588 mRNA Translation: BAC33829.1
BC055787 mRNA Translation: AAH55787.1
CCDSiCCDS37035.1 [Q6KCD5-1]
RefSeqiNP_081983.2, NM_027707.3 [Q6KCD5-1]
NP_957684.1, NM_201232.2 [Q6KCD5-2]
XP_006520057.1, XM_006519994.3 [Q6KCD5-1]
XP_006520058.1, XM_006519995.2 [Q6KCD5-1]
XP_017172234.1, XM_017316745.1

3D structure databases

SMRiQ6KCD5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi214531, 9 interactors
DIPiDIP-56622N
IntActiQ6KCD5, 14 interactors
MINTiQ6KCD5
STRINGi10090.ENSMUSP00000059385

PTM databases

iPTMnetiQ6KCD5
PhosphoSitePlusiQ6KCD5

Proteomic databases

EPDiQ6KCD5
jPOSTiQ6KCD5
PaxDbiQ6KCD5
PeptideAtlasiQ6KCD5
PRIDEiQ6KCD5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
71175

Genome annotation databases

EnsembliENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141 [Q6KCD5-1]
GeneIDi71175
KEGGimmu:71175
UCSCiuc007veq.2 mouse [Q6KCD5-1]
uc007ver.2 mouse [Q6KCD5-2]
uc007vev.1 mouse [Q6KCD5-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25836
MGIiMGI:1913976 Nipbl

Phylogenomic databases

eggNOGiKOG1020 Eukaryota
ENOG410XP32 LUCA
GeneTreeiENSGT00390000010427
HOGENOMiHOG000113787
InParanoidiQ6KCD5
KOiK06672
OMAiITPQDIN
OrthoDBi1314811at2759
PhylomeDBiQ6KCD5
TreeFamiTF313121

Enzyme and pathway databases

ReactomeiR-MMU-2470946 Cohesin Loading onto Chromatin

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nipbl mouse

Protein Ontology

More...
PROi
PR:Q6KCD5
RNActiQ6KCD5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022141 Expressed in 294 organ(s), highest expression level in thymus
GenevisibleiQ6KCD5 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B
PANTHERiPTHR21704 PTHR21704, 2 hits
PfamiView protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPBL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6KCD5
Secondary accession number(s): Q6KC78
, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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