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Entry version 56 (08 May 2019)
Sequence version 2 (07 Jan 2015)
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Protein
Submitted name:

Keyhole limpet hemocyanin1

Gene

klh1

Organism
Megathura crenulata (Giant keyhole limpet)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Keyhole limpet hemocyanin1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:klh1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMegathura crenulata (Giant keyhole limpet)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri55429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaVetigastropodaLepetellidaFissurelloideaFissurellidaeMegathura

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501272321616 – 3125Sequence analysisAdd BLAST3110

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 92Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini218 – 229Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini497 – 514Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini641 – 652Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini911 – 928Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini1054 – 1065Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini1326 – 1343Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini1463 – 1474Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini1886 – 1897Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2156 – 2173Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini2299 – 2310Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2576 – 2593Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini2709 – 2720Tyrosinase_Cu-bdInterPro annotationAdd BLAST12
Domaini2980 – 2997Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini3114 – 3125Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2786 – 2806Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 8 hits
2.60.310.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14830 Haemocyan_bet_s, 7 hits
PF00264 Tyrosinase, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092 TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056 SSF48056, 8 hits
SSF81277 SSF81277, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497 TYROSINASE_1, 7 hits
PS00498 TYROSINASE_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6KC56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LSVRLLIVVL ALANAENLVR KSVEHLTQEE TLDLQAALRE LQMDSSSIGF
60 70 80 90 100
QKIAAAHGAP ASCVHKDTSI ACCIHGMPTF PHWHRAYVVH MERALQTKRR
110 120 130 140 150
TSGLPYWDWT EPITQLPSLA ADPVYIDSQG GKAHTNYWYR GNIDFLDKKT
160 170 180 190 200
NRAVDDRLFE KVKPGQHTHL MESVLDALEQ DEFCKFEIQF ELAHNAIHYL
210 220 230 240 250
VGGKHDYSMA NLEYTAYDPI FFLHHSNVDR IFAIWQRLQE LRNKDPKAMD
260 270 280 290 300
CAQELLHQKM EPFSWEDNDI PLTNEHSTPA DLFDYCELHY DYDTLNLNGM
310 320 330 340 350
TPEELKTYLD ERSSRARAFA SFRLKGFGGS ANVFVYVCIP DDNDRNDDHC
360 370 380 390 400
EKAGDFFVLG GPSEMKWQFY RPYLFDLSDT VHKMGMKLDG HYTVKAELFS
410 420 430 440 450
VNGTALPDDL LPHPVVVHHP EKGFTDPPVK HHQSANLLVR KNINDLTREE
460 470 480 490 500
VLNLREAFHK FQEDRSVDGY QATAEYHGLP ARCPRPDAKD RYACCVHGMP
510 520 530 540 550
IFPHWHRLFV TQVEDALVGR GATIGIPYWD WTEPMTHIPG LAGNKTYVDS
560 570 580 590 600
HGASHTNPFH SSVIAFEENA PHTKRQIDQR LFKPATFGHH TDLFNQILYA
610 620 630 640 650
FEQEDYCDFE VQFEITHNTI HAWTGGSEHF SMSSLHYTAF DPLFYFHHSN
660 670 680 690 700
VDRLWAVWQA LQMRRHKPYR AHCAISLEHM HLKPFAFSSP LNNNEKTHAN
710 720 730 740 750
AMPNKIYDYE NVLHYTYEDL TFGGISLENI EKMIHENQQE DRIYAGFLLA
760 770 780 790 800
GIRTSANVDI FIKTTDSVQH KAGTFAVLGG SKEMKWGFDR VFKFDITHVL
810 820 830 840 850
KDLDLTADGD FEVTVDITEV DGTKLASSLI PHASVIREHA RVKFDKVPRS
860 870 880 890 900
RLIRKNVDRL SPEEMNELRK ALALLKEDKS AGGFQQLGAF HGEPKWCPSP
910 920 930 940 950
EASKKFACCV HGMSVFPHWH RLLTVQSENA LRRHGYDGAL PYWDWTSPLN
960 970 980 990 1000
HLPELADHEK YVDPEDGVEK HNPWFDGHID TVDKTTTRSV QNKLFEQPEF
1010 1020 1030 1040 1050
GHYTSIAKQV LLALEQDNFC DFEIQYEIAH NYIHALVGGA QPYGMASLRY
1060 1070 1080 1090 1100
TAFDPLFYLH HSNTDRIWAI WQALQKYRGK PYNVANCAVT SMREPLQPFG
1110 1120 1130 1140 1150
LSANINTDHV TKEHSVPFNV FDYKTNFNYE YDTLEFNGLS ISQLNKKLEA
1160 1170 1180 1190 1200
IKSQDRFFAG FLLSGFKKSS LVKFNICTDS SNCHPAGEFY LLGDENEMPW
1210 1220 1230 1240 1250
AYDRVFKYDI TEKLHDLKLH AEDHFYIDYE VFDLKPASLG KDLFKQPSVI
1260 1270 1280 1290 1300
HEPRIGHHEG EVYQAEVTSA NRIRKNIENL SLGELESLRA AFLEIENDGT
1310 1320 1330 1340 1350
YESIAKFHGS PGLCQLNGNP ISCCVHGMPT FPHWHRLYVV VVENALLKKG
1360 1370 1380 1390 1400
SSVAVPYWDW TKRIEHLPHL ISDATYYNSR QHHYETNPFH HGKITHENEI
1410 1420 1430 1440 1450
TTRDPKDSLF HSDYFYEQVL YALEQDNFCD FEIQLEILHN ALHSLLGGKG
1460 1470 1480 1490 1500
KYSMSNLDYA AFDPVFFLHH ATTDRIWAIW QDLQRFRKRP YREANCAIQL
1510 1520 1530 1540 1550
MHTPLQPFDK SDNNDEATKT HATPHDGFEY QNSFGYAYDN LELNHYSIPQ
1560 1570 1580 1590 1600
LDHMLQERKR HDRVFAGFLL HNIGTSADGH VFVCLPTGEH TKDCSHEAGM
1610 1620 1630 1640 1650
FSILGGQTEM SFVFDRLYKL DITKALKKNG VHLQGDFDLE IEITAVNGSH
1660 1670 1680 1690 1700
LDSHVIHSPT ILFEAGTDSA HTDDGHTEPV MIRKDITQLD KRQQLSLVKA
1710 1720 1730 1740 1750
LESMKADHSS DGFQAIASFH ALPPLCPSPA ASKRFACCVH GMATFPQWHR
1760 1770 1780 1790 1800
LYTVQFQDSL RKHGAVVGLP YWDWTLPRSE LPELLTVSTI HDPETGRDIP
1810 1820 1830 1840 1850
NPFIGSKIEF EGENVHTKRD INRDRLFQGS TKTHHNWFIE QALLALEQTN
1860 1870 1880 1890 1900
YCDFEVQFEI MHNGVHTWVG GKEPYGIGHL HYASYDPLFY IHHSQTDRIW
1910 1920 1930 1940 1950
AIWQSLQRFR GLSGSEANCA VNLMKTPLKP FSFGAPYNLN DHTHDFSKPE
1960 1970 1980 1990 2000
DTFDYQKFGY IYDTLEFAGW SIRGIDHIVR NRQEHSRVFA GFLLEGFGTS
2010 2020 2030 2040 2050
ATVDFQVCRT AGDCEDAGYF TVLGGEKEMP WAFDRLYKYD ITETLDKMNL
2060 2070 2080 2090 2100
RHDEIFQIEV TITSYDGTVL DSGLIPTPSI IYDPAHHDIS SHHLSLNKVR
2110 2120 2130 2140 2150
HDLSTLSERD IGSLKYALSS LQADTSADGF AAIASFHGLP AKCNDSHNNE
2160 2170 2180 2190 2200
VACCIHGMPT FPHWHRLYTL QFEQALRRHG SSVAVPYWDW TKPIHNIPHL
2210 2220 2230 2240 2250
FTDKEYYDVW RNKVMPNPFA RGYVPSHDTY TVRDVQEGLF HLTSTGEHSA
2260 2270 2280 2290 2300
LLNQALLALE QHDYCDFAVQ FEVMHNTIHY LVGGPQVYSL SSLHYASYDP
2310 2320 2330 2340 2350
IFFIHHSFVD KVWAVWQALQ EKRGLPSDRA DCAVSLMTQN MRPFHYEINH
2360 2370 2380 2390 2400
NQFTKKHAVP NDVFKYELLG YRYDNLEIGG MNLHEIEKEI KDKQHHVRVF
2410 2420 2430 2440 2450
AGFLLHGIRT SADVQFQICK TSEDCHHGGQ IFVLGGTKEM AWAYNRLFKY
2460 2470 2480 2490 2500
DITHALHDAH ITPEDVFHPS EPFFIKVSVT AVNGTVLPAS ILHAPTIIYE
2510 2520 2530 2540 2550
PGLDHHEDHH SSSMAGHGVR KEINTLTTAE VDNLKDAMRA VMADHGPNGY
2560 2570 2580 2590 2600
QAIAAFHGNP PMCPMPDGKN YSCCTHGMAT FPHWHRLYTK QMEDALTAHG
2610 2620 2630 2640 2650
ARVGLPYWDG TTAFTALPTF VTDEEDNPFH HGHIDYLGVD TTRSPRDKLF
2660 2670 2680 2690 2700
NDPERGSESF FYRQVLLALE QTDFCQFEVQ FEITHNAIHS WTGGLTPYGM
2710 2720 2730 2740 2750
STLEYTTYDP LFWLHHANTD RIWAIWQALQ EYRGLPYDHA NCEIQAMKRP
2760 2770 2780 2790 2800
LRPFSDPINH NAFTHSNAKP TDVFEYSRFN FQYDNLRFHG MTIKKLEHEL
2810 2820 2830 2840 2850
EKQKEEDRTF AAFLLHGIKK SADVSFDVCN HDGECHFAGT FAILGGEHEM
2860 2870 2880 2890 2900
PWSFDRLFRY DITQVLKQMH LEYDSDFTFH MRIIDTSGKQ LPSDLIKMPT
2910 2920 2930 2940 2950
VEHSPGGKHH EKHHEDHHED ILVRKNIHSL SHHEAEELRD ALYKLQNDES
2960 2970 2980 2990 3000
HGGYEHIAGF HGYPNLCPEK GDEKYPCCVH GMSIFPHWHR LHTIQFERAL
3010 3020 3030 3040 3050
KKHGSHLGIP YWDWTQTISS LPTFFADSGN NNPFFKYHIR SINQDTVRDV
3060 3070 3080 3090 3100
NEAIFQQTKF GEFSSIFYLA LQALEEDNYC DFEVQYEILH NEVHALIGGA
3110 3120
EKYSMSTLEY SAFDPYFMIH HASLD
Length:3,125
Mass (Da):359,205
Last modified:January 7, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71169281CA4A6341
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei3125Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ698339 mRNA Translation: CAG28307.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ698339 mRNA Translation: CAG28307.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1280.10, 8 hits
2.60.310.10, 7 hits
InterProiView protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830 Haemocyan_bet_s, 7 hits
PF00264 Tyrosinase, 9 hits
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 8 hits
SSF81277 SSF81277, 7 hits
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 7 hits
PS00498 TYROSINASE_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6KC56_MEGCR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6KC56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: January 7, 2015
Last modified: May 8, 2019
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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