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Protein

Autophagy-related protein 16-2

Gene

Atg16l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in autophagy.By similarity

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • negative stranded viral RNA replication Source: MGI
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processAutophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 16-2
Alternative name(s):
APG16-like 2
Gene namesi
Name:Atg16l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920933 Atg16l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371111 – 623Autophagy-related protein 16-2Add BLAST623

Proteomic databases

PaxDbiQ6KAU8
PRIDEiQ6KAU8

PTM databases

iPTMnetiQ6KAU8
PhosphoSitePlusiQ6KAU8

Expressioni

Gene expression databases

BgeeiENSMUSG00000047767 Expressed in 141 organ(s), highest expression level in blastocyst
ExpressionAtlasiQ6KAU8 baseline and differential
GenevisibleiQ6KAU8 MM

Interactioni

Protein-protein interaction databases

BioGridi216189, 1 interactor
ComplexPortaliCPX-355 Atg12-Atg5-Atg16l2 complex
STRINGi10090.ENSMUSP00000112500

Structurei

3D structure databases

ProteinModelPortaliQ6KAU8
SMRiQ6KAU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati338 – 377WD 1Add BLAST40
Repeati382 – 421WD 2Add BLAST40
Repeati424 – 458WD 3Add BLAST35
Repeati459 – 502WD 4Add BLAST44
Repeati504 – 543WD 5Add BLAST40
Repeati550 – 589WD 6Add BLAST40
Repeati593 – 623WD 7Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 229Sequence analysisAdd BLAST114

Sequence similaritiesi

Belongs to the WD repeat ATG16 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IMNZ Eukaryota
ENOG410YFNR LUCA
GeneTreeiENSGT00910000144058
HOGENOMiHOG000112569
HOVERGENiHBG050534
InParanoidiQ6KAU8
KOiK20868
OMAiQGPHCTA
OrthoDBiEOG091G0ML1
PhylomeDBiQ6KAU8
TreeFamiTF315541

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR013923 Autophagy-rel_prot_16
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08614 ATG16, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6KAU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPGAPCDP CAPAAVWKRH IVRQLRHRDR TQKALFLELV PAYNHLLEKA
60 70 80 90 100
ELLAKFSEKL KSEPKDAIST RHEDWREEVS GTGPDQVSSP ASLRVKWQQE
110 120 130 140 150
KKGLQLVCGE MAYQVVKKSA ALDTLQSQLE ERQDRLEALQ ACVVQLQEAR
160 170 180 190 200
AQQSRQLEER QAENAAQREA YETLLQQAVH QEAALRRLQE EARDLLEQLV
210 220 230 240 250
QRKARAAAER NLRNERRERA NQALVSQELK KAAKRTVSIS EIPNTLEDGT
260 270 280 290 300
KEETVALAPA ALPEFSESET CEKWKRPFRS ASATSLTLSR CVDVVKGLLD
310 320 330 340 350
FKKRRGHSVG GAPEQRYQSI PVCVSAQIPS QAQDVLDAHL SEVNAVCFGP
360 370 380 390 400
NSSLLATGGA DRLIHLWNVV GGRLEANQTL EGAGGSITSV DFDPSGSQVL
410 420 430 440 450
AATYNQAAQL WKVGETQSKE TLSGHKDKVT AAKFKLTRHQ AVTGSRDRTV
460 470 480 490 500
KEWDLGRAYC SRTINVLSYC NDVVCGDHII ISGHNDQKIR FWDSRGPHCI
510 520 530 540 550
QVIPVQGRVT SLHLSYDQLH LLSCSRDNTL KVIDLRISNI RQVFRADGFK
560 570 580 590 600
CSSDWTKAVF SPDRSYALAG SSNGDLYIWD VNTGKLETSL QGPHCTAVNA
610 620
VAWCFSGNHV VSVDQGRKVV LWH
Length:623
Mass (Da):69,241
Last modified:May 20, 2008 - v2
Checksum:i0358F9B735BC44D6
GO
Isoform 2 (identifier: Q6KAU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-403: GSQVLAAT → VRRLCPTA
     404-623: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):44,726
Checksum:i5F39D9A4CFCD26CB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z653D3Z653_MOUSE
Autophagy-related 16-like 2 alpha
Atg16l2 Atg16L2 alpha
602Annotation score:
D6RHC1D6RHC1_MOUSE
Autophagy-related protein 16-2
Atg16l2
81Annotation score:
A0A140LIS0A0A140LIS0_MOUSE
Autophagy-related protein 16-2
Atg16l2
46Annotation score:
A0A140LHW3A0A140LHW3_MOUSE
Autophagy-related protein 16-2
Atg16l2
44Annotation score:

Sequence cautioni

The sequence AAH60054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD21359 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033906396 – 403GSQVLAAT → VRRLCPTA in isoform 2. 1 Publication8
Alternative sequenceiVSP_033907404 – 623Missing in isoform 2. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131109 Transcribed RNA Translation: BAD21359.1 Sequence problems.
AC107638 Genomic DNA No translation available.
BC060054 mRNA Translation: AAH60054.1 Different initiation.
CCDSiCCDS52329.1 [Q6KAU8-1]
RefSeqiNP_001104581.1, NM_001111111.1 [Q6KAU8-1]
UniGeneiMm.275744

Genome annotation databases

EnsembliENSMUST00000120267; ENSMUSP00000112500; ENSMUSG00000047767 [Q6KAU8-1]
ENSMUST00000139609; ENSMUSP00000117387; ENSMUSG00000047767 [Q6KAU8-2]
ENSMUST00000143630; ENSMUSP00000117029; ENSMUSG00000047767 [Q6KAU8-2]
GeneIDi73683
KEGGimmu:73683
UCSCiuc009iof.2 mouse [Q6KAU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiA16L2_MOUSE
AccessioniPrimary (citable) accession number: Q6KAU8
Secondary accession number(s): Q6PAU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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