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Protein

Pleckstrin homology domain-containing family G member 2

Gene

Plekhg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42 (PubMed:11839748). Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). Involved in the regulation of actin polymerization (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 2
Short name:
PH domain-containing family G member 2
Alternative name(s):
Common site lymphoma/leukemia guanine nucleotide exchange factor
Short name:
Common site lymphoma/leukemia GEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plekhg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2141874 Plekhg2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068621 – 1340Pleckstrin homology domain-containing family G member 2Add BLAST1340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei441PhosphothreonineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei1215PhosphothreonineBy similarity1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6KAU7

PRoteomics IDEntifications database

More...
PRIDEi
Q6KAU7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6KAU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6KAU7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6KAU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymus, skeletal muscle, lung, testis, uterus, pancreas and heart and also expressed during embryogenesis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6KAU7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6KAU7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 279DHPROSITE-ProRule annotationAdd BLAST182
Domaini309 – 407PHPROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi589 – 594Poly-Glu6
Compositional biasi1303 – 1306Poly-Gly4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3518 Eukaryota
ENOG410XR81 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169126

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108256

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6KAU7

Database of Orthologous Groups

More...
OrthoDBi
147068at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6KAU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEGARGLSL PKPSLRLGCG HQGEVCDCAA VSDTPTAQAA TTMASPRGSG
60 70 80 90 100
SSTSLSTVGS EGDPSPACSA SRPEPLPEPP IRLHLLPVGI QGSVKPSRLE
110 120 130 140 150
RVAREIVETE RAYVRDLRSI VEDYLGPLMD GRALGLNMEQ VGTLFANIED
160 170 180 190 200
IYEFSSELLE DLEGCSSAGG IAECFVQRSE DFDIYTLYCM NYPSSLALLR
210 220 230 240 250
ELSVSPPATL WLQERQAQLR HSLPLQSFLL KPVQRILKYH LLLQELGKHW
260 270 280 290 300
AEGPDSGGRE MVEEAIVSMT AVAWYINDMK RKQEHAARLQ EVQRRLGGWT
310 320 330 340 350
GPELSAFGEL VLEGTFRGGG GGGPRLRGGE RLLFLFSRML LVAKRRGPEY
360 370 380 390 400
TYKGHIFCCN LSVSETPRDP LGFKVSDLTI PKHRHLFQAK NQEEKRLWIH
410 420 430 440 450
CLQRLFFENH PASIPAKAKQ VLLENSLHCA PKSKHIPEPP TSPLDSPRPR
460 470 480 490 500
DAPGFTPGRR NPAPSPRLSG SRRGRRQSEP AKEAYVIFPQ NDKPQVKHAG
510 520 530 540 550
SEGELHPSSE LQPVSASGLP EDLEDAGPPT LDPSGTSITE EILELLNQRG
560 570 580 590 600
LRDSGPATHD IPKFPRDSRV PVESEPLPFQ SLPSRESSEE EEEEDLETDE
610 620 630 640 650
REPSPLHVLE GLEGSSAAEI PCIPSLTDIP SEVPSLPEIP EAPCLPCLSD
660 670 680 690 700
ISGVFEVPCL SPTSTVPDIP SLATTPSFPC GSWLPGPLQE AAQPQATRRE
710 720 730 740 750
LLSGSNPGRL SESPSESREG QEDDTEGVSF SAVQREAGTS VQGFPEELEY
760 770 780 790 800
RSCSEIRSAW QALEQGQLAR PGFPEPLLIL EDSDLRGGST SGKTGMPHSE
810 820 830 840 850
RSASRVRELA RLYSERIQQM QRAETRASTN APRRRPRVLA QPQPSPCPPQ
860 870 880 890 900
EEAEPGALPA FGHVLVCELA FPLNCTQESV PLGPAVLVQA ATPLCIQGDD
910 920 930 940 950
LSGQNLNVSD LSKQGHLSSN SIPPPVPLPG QSNFQNIQVP STSLLPKQEP
960 970 980 990 1000
PDVQVPTAST LPDTSQLQSQ VPAATPSAGH RNCVEIQVQS TTSLPGQECQ
1010 1020 1030 1040 1050
ADTVALSKQE GHEDSQNPNK APGAEQRDVS IDQGLAVVGG RPVSPLPVCT
1060 1070 1080 1090 1100
SSPDQQIPAT TPLPLSTDFP DMEGPGALPL PTQEGRPDCS IPCNPLPSLS
1110 1120 1130 1140 1150
QDVQVPAVIP VSQLQGLTDT RATVPLSSHK QEDAPECLGP EPSLTDTPAP
1160 1170 1180 1190 1200
RLLSSLGQQN TTDGPVSAAA VPLTEQGCSQ DLQGLITSPV QTTMELPKPR
1210 1220 1230 1240 1250
GLVSRVATSE SLDLTPPHSP SLSTRQLLGP SAAALSRYLA ASYISQSLAR
1260 1270 1280 1290 1300
RQGPGGEGTV ASQGHWSSSA PTSRAPSPPP QPQPPAPPAR RLSYATTVSI
1310 1320 1330 1340
QVGGGGRLRP AKAQVRLNHP ALLAAPHPGA VGPSQGPGGS
Length:1,340
Mass (Da):143,376
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4FD7C9382658173
GO
Isoform 2 (identifier: Q6KAU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:1,298
Mass (Da):139,196
Checksum:i151E2D6A4378CB95
GO
Isoform 3 (identifier: Q6KAU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-478: S → SGEYPPLEGDPGSQWPGLLTSFFLPP

Note: No experimental confirmation available.
Show »
Length:1,365
Mass (Da):146,060
Checksum:i619B5B6EB6D266D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QKB6E9QKB6_MOUSE
PLEKHG2
Plekhg2 PLEKHG2
1,341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5N8D3Z5N8_MOUSE
Pleckstrin homology domain-containi...
Plekhg2
1,365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E8T4G5E8T4_MOUSE
Pleckstrin homology domain containi...
Plekhg2 mCG_141068
1,340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YY99D3YY99_MOUSE
Pleckstrin homology domain-containi...
Plekhg2
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1S3A0A0R4J1S3_MOUSE
Pleckstrin homology domain-containi...
Plekhg2
912Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1B1D3Z1B1_MOUSE
Pleckstrin homology domain-containi...
Plekhg2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFC7D6RFC7_MOUSE
Pleckstrin homology domain-containi...
Plekhg2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52436 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH56971 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD21360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37A → AA in AAH56971 (PubMed:15489334).Curated1
Sequence conflicti519L → P in AAH52436 (PubMed:15489334).Curated1
Sequence conflicti519L → P in AAH56971 (PubMed:15489334).Curated1
Sequence conflicti519L → P in BAE25733 (PubMed:16141072).Curated1
Sequence conflicti823 – 825AET → TRP in AAH25625 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285311 – 42Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_028532478S → SGEYPPLEGDPGSQWPGLLT SFFLPP in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF465238 mRNA Translation: AAL93134.1
AK131110 mRNA Translation: BAD21360.1 Different initiation.
BC025625 mRNA Translation: AAH25625.1
BC052436 mRNA Translation: AAH52436.1 Different initiation.
BC056971 mRNA Translation: AAH56971.1 Different initiation.
AK144152 mRNA Translation: BAE25733.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52162.1 [Q6KAU7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001077381.1, NM_001083912.1
NP_001277471.1, NM_001290542.1
NP_620091.2, NM_138752.2
XP_006539504.1, XM_006539441.2
XP_006539505.1, XM_006539442.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.235700

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
101497

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:101497

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465238 mRNA Translation: AAL93134.1
AK131110 mRNA Translation: BAD21360.1 Different initiation.
BC025625 mRNA Translation: AAH25625.1
BC052436 mRNA Translation: AAH52436.1 Different initiation.
BC056971 mRNA Translation: AAH56971.1 Different initiation.
AK144152 mRNA Translation: BAE25733.1
CCDSiCCDS52162.1 [Q6KAU7-1]
RefSeqiNP_001077381.1, NM_001083912.1
NP_001277471.1, NM_001290542.1
NP_620091.2, NM_138752.2
XP_006539504.1, XM_006539441.2
XP_006539505.1, XM_006539442.3
UniGeneiMm.235700

3D structure databases

ProteinModelPortaliQ6KAU7
SMRiQ6KAU7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6KAU7
PhosphoSitePlusiQ6KAU7
SwissPalmiQ6KAU7

Proteomic databases

PaxDbiQ6KAU7
PRIDEiQ6KAU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101497
KEGGimmu:101497

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64857
MGIiMGI:2141874 Plekhg2

Phylogenomic databases

eggNOGiKOG3518 Eukaryota
ENOG410XR81 LUCA
HOGENOMiHOG000169126
HOVERGENiHBG108256
InParanoidiQ6KAU7
OrthoDBi147068at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plekhg2 mouse

Protein Ontology

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PROi
PR:Q6KAU7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHG2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6KAU7
Secondary accession number(s): A0PJD9
, Q3UNL4, Q6PGK2, Q7TS89, Q8R4H6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 16, 2019
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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