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Protein

Exocyst complex component 3

Gene

Exoc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene namesi
Name:Exoc3
Synonyms:Sec6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2443972 Exoc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189261 – 755Exocyst complex component 3Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6KAR6
PaxDbiQ6KAR6
PeptideAtlasiQ6KAR6
PRIDEiQ6KAR6

PTM databases

iPTMnetiQ6KAR6
PhosphoSitePlusiQ6KAR6

Expressioni

Gene expression databases

BgeeiENSMUSG00000034152 Expressed in 238 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EXOC3
ExpressionAtlasiQ6KAR6 baseline and differential
GenevisibleiQ6KAR6 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (PubMed:18480549). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6KAR6, 6 interactors
MINTiQ6KAR6
STRINGi10090.ENSMUSP00000039416

Structurei

3D structure databases

ProteinModelPortaliQ6KAR6
SMRiQ6KAR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 62Sequence analysisAdd BLAST29
Coiled coili618 – 649Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOGENOMiHOG000043095
HOVERGENiHBG034187
InParanoidiQ6KAR6
KOiK06110
OMAiGRPKRWK
OrthoDBiEOG091G02T2
PhylomeDBiQ6KAR6
TreeFamiTF314979

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6KAR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKDSACFLT MKETDLEAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK
60 70 80 90 100
ASVEARLKAA IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI
110 120 130 140 150
NTIESLKDVK DAVVQHSQLA AAVENLKNIF SVPEIVRETQ DLIEQGALLQ
160 170 180 190 200
AHRKLMDLEC SRDGLMCEQY RMDSGNKRDM TLIHGYFGST QGLSDELAKQ
210 220 230 240 250
LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR
260 270 280 290 300
PKNWKEKMFA ILDRTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL
310 320 330 340 350
IVAKNLMVQC FPPHYEIFKN LLSMYHQALS TRMQDLASED LEANEIVSLL
360 370 380 390 400
TWVLNTYTSA EMMGNVELAP EVDVSALEPL LSPNIVSELL DTYMSTLTSN
410 420 430 440 450
IIAWLRKALE TDKKDWSKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA
460 470 480 490 500
QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ LYKEEHLRNR QHPHCYVQYM
510 520 530 540 550
IAIINNCQTF KESIISLKRK YLKTEAEEGL CLSQPSMDGI LDAIAKEGCS
560 570 580 590 600
SLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY
610 620 630 640 650
KKRMTAEAHR RVVVEYLRAV MQKRISFRSA EERKEGAEKM VREAEQLRFL
660 670 680 690 700
FRKLASGFGE DADGHCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD
710 720 730 740 750
DHIGALLALR GDASRDMKQT IMETLEQGPM QASPNYVPIF KEIVVPSLNV

AKLLK
Length:755
Mass (Da):86,455
Last modified:November 22, 2005 - v2
Checksum:i47B4D8AFAAC7CBCB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VKY4A0A1Y7VKY4_MOUSE
Exocyst complex component 3
Exoc3
106Annotation score:
A0A1Y7VP30A0A1Y7VP30_MOUSE
Exocyst complex component 3
Exoc3
72Annotation score:

Sequence cautioni

The sequence BAD21391 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131141 mRNA Translation: BAD21391.1 Different initiation.
CCDSiCCDS26640.1
RefSeqiNP_796307.2, NM_177333.3
XP_006517254.1, XM_006517191.2
UniGeneiMm.261859

Genome annotation databases

EnsembliENSMUST00000035934; ENSMUSP00000039416; ENSMUSG00000034152
GeneIDi211446
KEGGimmu:211446
UCSCiuc007reu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131141 mRNA Translation: BAD21391.1 Different initiation.
CCDSiCCDS26640.1
RefSeqiNP_796307.2, NM_177333.3
XP_006517254.1, XM_006517191.2
UniGeneiMm.261859

3D structure databases

ProteinModelPortaliQ6KAR6
SMRiQ6KAR6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6KAR6, 6 interactors
MINTiQ6KAR6
STRINGi10090.ENSMUSP00000039416

PTM databases

iPTMnetiQ6KAR6
PhosphoSitePlusiQ6KAR6

Proteomic databases

EPDiQ6KAR6
PaxDbiQ6KAR6
PeptideAtlasiQ6KAR6
PRIDEiQ6KAR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035934; ENSMUSP00000039416; ENSMUSG00000034152
GeneIDi211446
KEGGimmu:211446
UCSCiuc007reu.1 mouse

Organism-specific databases

CTDi11336
MGIiMGI:2443972 Exoc3

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOGENOMiHOG000043095
HOVERGENiHBG034187
InParanoidiQ6KAR6
KOiK06110
OMAiGRPKRWK
OrthoDBiEOG091G02T2
PhylomeDBiQ6KAR6
TreeFamiTF314979

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiExoc3 mouse
PROiPR:Q6KAR6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034152 Expressed in 238 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_EXOC3
ExpressionAtlasiQ6KAR6 baseline and differential
GenevisibleiQ6KAR6 MM

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC3_MOUSE
AccessioniPrimary (citable) accession number: Q6KAR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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