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Entry version 135 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Ribonucleoside-diphosphate reductase

Gene

RnrL2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotationARBA annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzymeARBA annotation, OxidoreductaseUniRule annotationARBA annotation
Biological processDNA replicationUniRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.17.4.1, 4460

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00326

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotationARBA annotation (EC:1.17.4.1UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RnrL2Imported
Ordered Locus Names:Os02g0804900Imported
ORF Names:OSNPB_020804900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS02T0804900-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6K848

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92ATP-coneInterPro annotationAdd BLAST92

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1112, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000404_1_0_1

KEGG Orthology (KO)

More...
KOi
K10807

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNYAWTK

Database of Orthologous Groups

More...
OrthoDBi
156716at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005144, ATP-cone_dom
IPR013346, NrdE_NrdA
IPR000788, RNR_lg_C
IPR013509, RNR_lsu_N
IPR008926, RNR_R1-su_N
IPR039718, Rrm1

The PANTHER Classification System

More...
PANTHERi
PTHR11573, PTHR11573, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03477, ATP-cone, 1 hit
PF02867, Ribonuc_red_lgC, 1 hit
PF00317, Ribonuc_red_lgN, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01183, RIBORDTASEM1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48168, SSF48168, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02506, NrdE_NrdA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51161, ATP_CONE, 1 hit
PS00089, RIBORED_LARGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6K848-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYVVKRDGRQ EAVHFDKITA RLKRLSYGLS QEHCDPVLVA QKVCAGVYKG
60 70 80 90 100
VTTSQLGELA AETAAAMTAS HPDYASLAAR IAISNLHKTT MKSFSETIKV
110 120 130 140 150
MYMHYDERSG LLAPLIADDV YEIIMKNTTR LDSEIIYDRD FDYDYFGFKT
160 170 180 190 200
LERSYLLKVV GKVVERPQHM LMRVSIGIHK DDIESAIKTY HMMSQRWFTH
210 220 230 240 250
ASPTLFNAGT PRPQLSSCFL ICMNDDSIEG IYDTLSECAT ISKCAGGIGL
260 270 280 290 300
SIHNIRATGS YIRGTNGTSN GIVPMLRVFN DTARYVDQGG GKRKGAFAIY
310 320 330 340 350
LEPWHADIFE FLDLRKNHGK EENRARDLFY ALWIPDLFME RVQNNENWSL
360 370 380 390 400
FCPNEAPGLA DCWGDEFQNL YKKYEREGKA KKVVSAQALW FDILKAQIET
410 420 430 440 450
GTPYMLYKDS CNRKSNQQNL GTIKSSNLCT EIIEFTSPTE TAVCNLASIG
460 470 480 490 500
LPRFVREKGV PMESHPAKLV GSNGSKNRYF DFDKLAEITS IVTRNLNKII
510 520 530 540 550
DTNYYPVETA KRSNMRHRPI GIGVQGLADT FILLGMPFDS TEAQQLNKDI
560 570 580 590 600
FETIYYHALK ASAEIAAKEG PYETYSGSPV SKGILQPDMW NVVPSDRWNW
610 620 630 640 650
SDLREMISKV GVRNSLLIAP MPTASTSQIL GNNECFEPYT SNIYSRRVLS
660 670 680 690 700
GEFVVVNKHL LHDLTEMGIW SPVLKNKIVY EDGSVQKISE IPDDLKAIYR
710 720 730 740 750
TVWEIKQKTI VDMAIDRGCY IDQSQSLNIH MDQPNFGKLT SLHFHAWSKG
760 770 780 790 800
LKTGMYYLRT RAAADAIKFT VDTTLLKDKQ HNAEEEDVQS KMAEVVCSLN
810
NRDECLACGS
Length:810
Mass (Da):91,488
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48846AC842DCB607
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU602346 mRNA Translation: ACC95436.1
AP014958 Genomic DNA Translation: BAS81453.1

NCBI Reference Sequences

More...
RefSeqi
XP_015627037.1, XM_015771551.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os02t0804900-01; Os02t0804900-01; Os02g0804900

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4331059

Gramene; a comparative resource for plants

More...
Gramenei
Os02t0804900-01; Os02t0804900-01; Os02g0804900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4331059

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU602346 mRNA Translation: ACC95436.1
AP014958 Genomic DNA Translation: BAS81453.1
RefSeqiXP_015627037.1, XM_015771551.1

3D structure databases

SMRiQ6K848
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS02T0804900-01

Genome annotation databases

EnsemblPlantsiOs02t0804900-01; Os02t0804900-01; Os02g0804900
GeneIDi4331059
GrameneiOs02t0804900-01; Os02t0804900-01; Os02g0804900
KEGGiosa:4331059

Phylogenomic databases

eggNOGiKOG1112, Eukaryota
HOGENOMiCLU_000404_1_0_1
KOiK10807
OMAiRNYAWTK
OrthoDBi156716at2759

Enzyme and pathway databases

UniPathwayiUPA00326
BRENDAi1.17.4.1, 4460

Family and domain databases

InterProiView protein in InterPro
IPR005144, ATP-cone_dom
IPR013346, NrdE_NrdA
IPR000788, RNR_lg_C
IPR013509, RNR_lsu_N
IPR008926, RNR_R1-su_N
IPR039718, Rrm1
PANTHERiPTHR11573, PTHR11573, 1 hit
PfamiView protein in Pfam
PF03477, ATP-cone, 1 hit
PF02867, Ribonuc_red_lgC, 1 hit
PF00317, Ribonuc_red_lgN, 1 hit
PRINTSiPR01183, RIBORDTASEM1
SUPFAMiSSF48168, SSF48168, 1 hit
TIGRFAMsiTIGR02506, NrdE_NrdA, 1 hit
PROSITEiView protein in PROSITE
PS51161, ATP_CONE, 1 hit
PS00089, RIBORED_LARGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6K848_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6K848
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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