UniProtKB - Q6JHV3 (Q6JHV3_HUMAN)
Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
USP3
Organism
Homo sapiens (Human)
Status
Functioni
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.UniRule annotation
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationARBA annotation EC:3.4.19.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 82 | UBP-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- protein deubiquitination Source: UniProtKB-UniRule
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotation |
Biological process | Ubl conjugation pathwayUniRule annotation |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | C19.026 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation) |
Gene namesi | Name:USP3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12626, USP3 |
VEuPathDBi | HostDB:ENSG00000140455.16 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasmic ribonucleoprotein granule Source: HPA
- Flemming body Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000140455, Expressed in stomach and 228 other tissues |
ExpressionAtlasi | Q6JHV3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 82 | UBP-typeInterPro annotationAdd BLAST | 78 | |
Domaini | 137 – 489 | USPInterPro annotationAdd BLAST | 353 |
Sequence similaritiesi
Belongs to the peptidase C19 family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 5 – 82 | UBP-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157850 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom IPR013083, Znf_RING/FYVE/PHD IPR001607, Znf_UBP |
Pfami | View protein in Pfam PF00443, UCH, 1 hit PF02148, zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00290, ZnF_UBP, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit PS50271, ZF_UBP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q6JHV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSPPHLAVC RSNKSPWVCL TCSSVHCGRY VNGHAKKHYE DAQVPLTNHK
60 70 80 90 100
KSEKQDKVQH TVCMDCSSYS TYCYRCDDFV VNDTKLGLVQ KVREHLQNLE
110 120 130 140 150
NSAFTADRHK KRKLLENSTL NSKLLKVNGS TTAICATGLR NLGNTCFMNA
160 170 180 190 200
ILQSLSNIEQ FCCYFKELPA VELRNGKTAG RRTYHTRSQG DNNVSLVEEF
210 220 230 240 250
RKTLCALWQG SQTAFSPESL FYVVWKIMPN FRGYQQQDAH EFMRYLLDHL
260 270 280 290 300
HLELQGGFNG VSRSAILQEN STLSASNKCC INGASTVVTA IFGGILQNEV
310 320 330 340 350
NCLICGTESR KFDPFLDLSL DIPSQFRSKR SKNQENGPVC SLRDCLRSFT
360 370 380 390 400
DLEELDETEL YMCHKCKKKQ KSTKKFWIQK LPKVLCLHLK RFHWTAYLRN
410 420 430 440 450
KVDTYVEFPL RGLDMKCYLL EPENSGPESC LYDLAAVVVH HGSGVGSGHY
460 470 480 490
TAYATHEGRW FHFNDSTVTL TDEETVVKAK AYILFYVEHQ AKAGSDKL
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y6I4 | UBP3_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 520 | Annotation score: | ||
H0YMI4 | H0YMI4_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 503 | Annotation score: | ||
H0YLB7 | H0YLB7_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 431 | Annotation score: | ||
H0YKU8 | H0YKU8_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 443 | Annotation score: | ||
H0YLG0 | H0YLG0_HUMAN | Ubiquitinyl hydrolase 1 | USP3 | 133 | Annotation score: | ||
H0YM72 | H0YM72_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 106 | Annotation score: | ||
H0YMP6 | H0YMP6_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 132 | Annotation score: | ||
H0YL81 | H0YL81_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 126 | Annotation score: | ||
H0YNX9 | H0YNX9_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 39 | Annotation score: | ||
H0YLJ0 | H0YLJ0_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP3 | 55 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007950 Genomic DNA No translation available. AC118274 Genomic DNA No translation available. AY461579 mRNA Translation: AAT37507.1 |
RefSeqi | XP_016878252.1, XM_017022763.1 XP_016878253.1, XM_017022764.1 XP_016878254.1, XM_017022765.1 |
Genome annotation databases
Ensembli | ENST00000268049; ENSP00000268049; ENSG00000140455 |
GeneIDi | 9960 |
UCSCi | uc059kcy.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007950 Genomic DNA No translation available. AC118274 Genomic DNA No translation available. AY461579 mRNA Translation: AAT37507.1 |
RefSeqi | XP_016878252.1, XM_017022763.1 XP_016878253.1, XM_017022764.1 XP_016878254.1, XM_017022765.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C19.026 |
Proteomic databases
MaxQBi | Q6JHV3 |
PRIDEi | Q6JHV3 |
ProteomicsDBi | 66514 |
Protocols and materials databases
Antibodypediai | 13304, 289 antibodies |
Genome annotation databases
Ensembli | ENST00000268049; ENSP00000268049; ENSG00000140455 |
GeneIDi | 9960 |
UCSCi | uc059kcy.1, human |
Organism-specific databases
CTDi | 9960 |
HGNCi | HGNC:12626, USP3 |
OpenTargetsi | ENSG00000140455 |
VEuPathDBi | HostDB:ENSG00000140455.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157850 |
Miscellaneous databases
BioGRID-ORCSi | 9960, 6 hits in 876 CRISPR screens |
ChiTaRSi | USP3, human |
GenomeRNAii | 9960 |
Gene expression databases
Bgeei | ENSG00000140455, Expressed in stomach and 228 other tissues |
ExpressionAtlasi | Q6JHV3, baseline and differential |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom IPR013083, Znf_RING/FYVE/PHD IPR001607, Znf_UBP |
Pfami | View protein in Pfam PF00443, UCH, 1 hit PF02148, zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00290, ZnF_UBP, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit PS50271, ZF_UBP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6JHV3_HUMAN | |
Accessioni | Q6JHV3Primary (citable) accession number: Q6JHV3 Secondary accession number(s): E9PE27 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |