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Entry version 122 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

DNA polymerase kappa

Gene

POLK

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Template-directed low-fidelity DNA polymerase specifically involved in DNA repair (PubMed:15200644, PubMed:17550419). Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8-oxoG DNA lesions (PubMed:17550419). Probably involved in consecutive DNA replication cycles in the absence of mitosis (PubMed:15200644). Binds preferentially template-primer DNA substrates or single-stranded DNA (PubMed:17550419). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Unable to bypass a single 1,N6-ethenoadenine (epsilon-dA) or an abasic site lesions in DNA templates.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

With cytosine as template, kcat is 0.024 min(-1) with dATP as substrate, kcat is 0.125 min(-1) with dGTP as substrate, kcat is 0.057 min(-1) with dATTP as substrate and kcat is 0.0038 min(-1) with dCTP as substrate. With thymine as template, kcat is 0.157 min(-1) with dATP as substrate and kcat is 0.038 min(-1) with dCTP as substrate. With adenine as template, kcat is 0.207 min(-1) with dTTP as substrate and kcat is 0.045 min(-1) with dCTP as substrate. With guanine as template, kcat is 0.022 min(-1) with dTTP as substrate and kcat is 0.061 min(-1) with dCTP as substrate.1 Publication
  1. KM=52.6 µM for dATP (with cytosine as template)1 Publication
  2. KM=12.51 µM for dGTP (with cytosine as template)1 Publication
  3. KM=83.3 µM for dTTP (with cytosine as template)1 Publication
  4. KM=156.8 µM for dCTP (with cytosine as template)1 Publication
  5. KM=2.61 µM for dATP (with thymine as template)1 Publication
  6. KM=62.29 µM for dCTP (with thymine as template)1 Publication
  7. KM=4.7 µM for dTTP (with adenine as template)1 Publication
  8. KM=100.41 µM for dCTP (with adenine as template)1 Publication
  9. KM=29.16 µM for dTTP (with guanine as template)1 Publication
  10. KM=7.76 µM for dCTP (with guanine as template)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109MagnesiumPROSITE-ProRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei114Substrate discriminationPROSITE-ProRule annotation1
    Metal bindingi200MagnesiumPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei201PROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
    Biological processDNA damage, DNA repair, DNA replication
    LigandMagnesium, Metal-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    DNA polymerase kappa1 Publication (EC:2.7.7.72 Publications)
    Short name:
    AtPOLK1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:POLK1 Publication
    Ordered Locus Names:At1g49980Imported
    ORF Names:F2J10.13Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT1G49980

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2031050 AT1G49980

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi200D → A: Loss of DNA polymerase kappa activity. 1 Publication1
    Mutagenesisi201E → A: Loss of DNA polymerase kappa activity. 1 Publication1
    Mutagenesisi479 – 671Missing : Increased DNA polymerase kappa activity and processivity leading to enhanced catalytic efficiency and fidelity, due to a greater ability to insert the correct nucleotide. 2 PublicationsAdd BLAST193

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004412491 – 671DNA polymerase kappaAdd BLAST671

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6JDV7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in roots, leaves, stems, flowers and siliques. Present in endoreduplicating cells.1 Publication

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    In young seedlings, strongly expressed in cotyledons, and, at lower levels, in the hypocotyl adjacent region. Later confined to cotyledons vascular tissues and observed in leaf primordia and young growing leaves. Accumulates in the basal part of trichomes. In mature flowers, present in sepals, stamen filaments and stigma. Accumulates progressively in maturating siliques.1 Publication

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6JDV7 baseline and differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT1G49980.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6JDV7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 285UmuCPROSITE-ProRule annotationAdd BLAST181

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi625 – 632Nuclear localization signalPROSITE-ProRule annotation8

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The C-terminal region negatively affects catalytic efficiency for correct nucleotide insertion, thus decreasing the fidelity of the enzyme.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the DNA polymerase type-Y family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2094 Eukaryota
    COG0389 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000082709

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6JDV7

    KEGG Orthology (KO)

    More...
    KOi
    K03511

    Database of Orthologous Groups

    More...
    OrthoDBi
    878533at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6JDV7

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03586 PolY_Pol_IV_kappa, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1490.100, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01113 DNApol_IV, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036775 DNA_pol_Y-fam_lit_finger_sf
    IPR017961 DNA_pol_Y-fam_little_finger
    IPR022880 DNApol_IV
    IPR001126 UmuC
    IPR041298 Znf_UBZ

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00817 IMS, 1 hit
    PF11799 IMS_C, 1 hit
    PF18439 zf_UBZ, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF100879 SSF100879, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50173 UMUC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: Additional isoforms seem to exist.1 PublicationImported

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6JDV7-1) [UniParc]FASTAAdd to basket
    Also known as: AtPOLKa1 Publication

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDNGESSSTN NSSRPWESYN TVFTNAKAGM EGVDKEKVQR VVYEMSKGSK
    60 70 80 90 100
    YFQNEERKEA LMKQKIEHMR DRCAKLSSLD LSNYQKVVDK RILELEATRD
    110 120 130 140 150
    LSRIWLHVDM DAFYAAVETL SDPSIKGKPM AVGGLSMIST ANYEARKFGV
    160 170 180 190 200
    RAAMPGFIAR KLCPDLIFVP VDFTKYTHYS DLTRKVFRNY DPHFIAGSLD
    210 220 230 240 250
    EAYLDITEVC RERGLSGGEI AEELRSSVYS ETGLTCSAGV AANRLLAKVC
    260 270 280 290 300
    SDINKPNGQF VLQNDRSTVM TFVSFLPVRK IGGIGKVTEH ILKDALGIKT
    310 320 330 340 350
    CEEMVQKGSL LYALFSQSSA DFFLSVGLGL GGTNTPQVRS RKSISSERTF
    360 370 380 390 400
    AATGDERLLY SKLDELAEML SHDMKKEGLT ARTLTLKLKT ASFEIRSRAV
    410 420 430 440 450
    SLQRYTCSSD DILKHATKLL KAELPVSVRL IGLRMSQFVE EIRNSDPSQG
    460 470 480 490 500
    TITKFIVQKD SSRQAQDLDD NDSFDLDANK NCLSNDESGN VSFGSHETSS
    510 520 530 540 550
    AHLKDVVEYE ERSQIDSGKV IPNQECMKKE ERLQILEGDS LLKKYKECKP
    560 570 580 590 600
    DTSHSMNDNS NATEAVSVFP QTEPLYWIDG YKCVLCGIEL PPSFVEERQE
    610 620 630 640 650
    HSDFHLAQRL QNEETGSSSS TTPSKRRILG KEKVNSKPKK QKPDQKDSSK
    660 670
    HIPIHAFFTK SNQNSNETQR K
    Length:671
    Mass (Da):75,252
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45FE9D4A3460ABEB
    GO
    Isoform 2 (identifier: Q6JDV7-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-269: Missing.

    Note: No experimental confirmation available.Imported
    Show »
    Length:402
    Mass (Da):45,053
    Checksum:i8D09E6F34D39F490
    GO
    Isoform 3 (identifier: Q6JDV7-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         666-671: Missing.

    Note: Derived from EST data. No experimental confirmation available.Imported
    Show »
    Length:665
    Mass (Da):74,495
    Checksum:iBBEB3CF2A6346689
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1P8ANG9A0A1P8ANG9_ARATH
    DNA/RNA polymerases superfamily pro...
    At1g49980, F2J10.13, F2J10_13
    654Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1P8ANG2A0A1P8ANG2_ARATH
    DNA/RNA polymerases superfamily pro...
    At1g49980, F2J10.13, F2J10_13
    512Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1P8ANJ3A0A1P8ANJ3_ARATH
    DNA/RNA polymerases superfamily pro...
    At1g49980, F2J10.13, F2J10_13
    518Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAF76444 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0590521 – 269Missing in isoform 2. Add BLAST269
    Alternative sequenceiVSP_059053666 – 671Missing in isoform 3. 6

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY508701 mRNA Translation: AAS91582.1
    AC015445 Genomic DNA Translation: AAF76444.1 Sequence problems.
    CP002684 Genomic DNA Translation: AEE32503.1
    CP002684 Genomic DNA Translation: ANM58190.1
    CP002684 Genomic DNA Translation: ANM58192.1
    CP002684 Genomic DNA Translation: ANM58193.1
    CP002684 Genomic DNA Translation: ANM58196.1
    AK221284 mRNA Translation: BAD93992.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    C96536

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001320644.1, NM_001333412.1 [Q6JDV7-3]
    NP_001320646.1, NM_001333409.1 [Q6JDV7-3]
    NP_001320647.1, NM_001333410.1 [Q6JDV7-3]
    NP_001320650.1, NM_001333413.1 [Q6JDV7-3]
    NP_175420.3, NM_103886.4 [Q6JDV7-1]

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT1G49980.1; AT1G49980.1; AT1G49980 [Q6JDV7-1]
    AT1G49980.4; AT1G49980.4; AT1G49980 [Q6JDV7-3]
    AT1G49980.5; AT1G49980.5; AT1G49980 [Q6JDV7-3]
    AT1G49980.7; AT1G49980.7; AT1G49980 [Q6JDV7-3]
    AT1G49980.8; AT1G49980.8; AT1G49980 [Q6JDV7-3]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    841422

    Gramene; a comparative resource for plants

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    Gramenei
    AT1G49980.1; AT1G49980.1; AT1G49980 [Q6JDV7-1]
    AT1G49980.4; AT1G49980.4; AT1G49980 [Q6JDV7-3]
    AT1G49980.5; AT1G49980.5; AT1G49980 [Q6JDV7-3]
    AT1G49980.7; AT1G49980.7; AT1G49980 [Q6JDV7-3]
    AT1G49980.8; AT1G49980.8; AT1G49980 [Q6JDV7-3]

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    ath:AT1G49980

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY508701 mRNA Translation: AAS91582.1
    AC015445 Genomic DNA Translation: AAF76444.1 Sequence problems.
    CP002684 Genomic DNA Translation: AEE32503.1
    CP002684 Genomic DNA Translation: ANM58190.1
    CP002684 Genomic DNA Translation: ANM58192.1
    CP002684 Genomic DNA Translation: ANM58193.1
    CP002684 Genomic DNA Translation: ANM58196.1
    AK221284 mRNA Translation: BAD93992.1
    PIRiC96536
    RefSeqiNP_001320644.1, NM_001333412.1 [Q6JDV7-3]
    NP_001320646.1, NM_001333409.1 [Q6JDV7-3]
    NP_001320647.1, NM_001333410.1 [Q6JDV7-3]
    NP_001320650.1, NM_001333413.1 [Q6JDV7-3]
    NP_175420.3, NM_103886.4 [Q6JDV7-1]

    3D structure databases

    SMRiQ6JDV7
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT1G49980.1

    Proteomic databases

    PaxDbiQ6JDV7

    Genome annotation databases

    EnsemblPlantsiAT1G49980.1; AT1G49980.1; AT1G49980 [Q6JDV7-1]
    AT1G49980.4; AT1G49980.4; AT1G49980 [Q6JDV7-3]
    AT1G49980.5; AT1G49980.5; AT1G49980 [Q6JDV7-3]
    AT1G49980.7; AT1G49980.7; AT1G49980 [Q6JDV7-3]
    AT1G49980.8; AT1G49980.8; AT1G49980 [Q6JDV7-3]
    GeneIDi841422
    GrameneiAT1G49980.1; AT1G49980.1; AT1G49980 [Q6JDV7-1]
    AT1G49980.4; AT1G49980.4; AT1G49980 [Q6JDV7-3]
    AT1G49980.5; AT1G49980.5; AT1G49980 [Q6JDV7-3]
    AT1G49980.7; AT1G49980.7; AT1G49980 [Q6JDV7-3]
    AT1G49980.8; AT1G49980.8; AT1G49980 [Q6JDV7-3]
    KEGGiath:AT1G49980

    Organism-specific databases

    AraportiAT1G49980
    TAIRilocus:2031050 AT1G49980

    Phylogenomic databases

    eggNOGiKOG2094 Eukaryota
    COG0389 LUCA
    HOGENOMiHOG000082709
    InParanoidiQ6JDV7
    KOiK03511
    OrthoDBi878533at2759
    PhylomeDBiQ6JDV7

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:Q6JDV7

    Gene expression databases

    ExpressionAtlasiQ6JDV7 baseline and differential

    Family and domain databases

    CDDicd03586 PolY_Pol_IV_kappa, 1 hit
    Gene3Di3.30.1490.100, 1 hit
    HAMAPiMF_01113 DNApol_IV, 1 hit
    InterProiView protein in InterPro
    IPR036775 DNA_pol_Y-fam_lit_finger_sf
    IPR017961 DNA_pol_Y-fam_little_finger
    IPR022880 DNApol_IV
    IPR001126 UmuC
    IPR041298 Znf_UBZ
    PfamiView protein in Pfam
    PF00817 IMS, 1 hit
    PF11799 IMS_C, 1 hit
    PF18439 zf_UBZ, 1 hit
    SUPFAMiSSF100879 SSF100879, 1 hit
    PROSITEiView protein in PROSITE
    PS50173 UMUC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLK_ARATH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6JDV7
    Secondary accession number(s): A0A1P8ANH5, Q56YN7, Q9LPM1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
    Last sequence update: July 5, 2004
    Last modified: September 18, 2019
    This is version 122 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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