UniProtKB - Q6JBY9 (CPZIP_HUMAN)
Protein
CapZ-interacting protein
Gene
RCSD1
Organism
Homo sapiens (Human)
Status
Functioni
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.1 Publication
GO - Molecular functioni
- actin filament binding Source: BHF-UCL
GO - Biological processi
- cellular hyperosmotic response Source: BHF-UCL
- skeletal muscle contraction Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | Q6JBY9 |
Names & Taxonomyi
Protein namesi | Recommended name: CapZ-interacting proteinAlternative name(s): Protein kinase substrate CapZIP RCSD domain-containing protein 1 |
Gene namesi | Name:RCSD1 Synonyms:CAPZIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198771.10 |
HGNCi | HGNC:28310, RCSD1 |
MIMi | 610579, gene |
neXtProti | NX_Q6JBY9 |
Subcellular locationi
Cytoskeleton
- actin filament Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 92241 |
OpenTargetsi | ENSG00000198771 |
PharmGKBi | PA142671088 |
Miscellaneous databases
Pharosi | Q6JBY9, Tbio |
Polymorphism and mutation databases
BioMutai | RCSD1 |
DMDMi | 74758031 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320262 | 1 – 416 | CapZ-interacting proteinAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 68 | Phosphoserine; by MAPK8; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | Phosphoserine; by MAPK8; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 108 | Phosphoserine; by MAPK12 and MAPK13Combined sources1 Publication | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 126 | PhosphoserineBy similarity | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 135 | PhosphoserineBy similarity | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 177 | PhosphoserineCombined sources | 1 | |
Modified residuei | 179 | Phosphoserine; by MAPKAPK2 and MAPKAPK3Combined sources1 Publication | 1 | |
Modified residuei | 216 | Phosphoserine; by MAPK8; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 244 | Phosphoserine; by MAPKAPK2 or MAPKAPK3; in vitro1 Publication | 1 | |
Modified residuei | 267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 298 | PhosphoserineCombined sources | 1 | |
Modified residuei | 333 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Dephosphorylation results in its dissociation from CAPZA2.
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-998 |
EPDi | Q6JBY9 |
jPOSTi | Q6JBY9 |
MassIVEi | Q6JBY9 |
MaxQBi | Q6JBY9 |
PaxDbi | Q6JBY9 |
PeptideAtlasi | Q6JBY9 |
PRIDEi | Q6JBY9 |
ProteomicsDBi | 66511 [Q6JBY9-1] 66512 [Q6JBY9-2] |
PTM databases
iPTMneti | Q6JBY9 |
PhosphoSitePlusi | Q6JBY9 |
Expressioni
Tissue specificityi
Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.1 Publication
Gene expression databases
Bgeei | ENSG00000198771, Expressed in leukocyte and 196 other tissues |
ExpressionAtlasi | Q6JBY9, baseline and differential |
Genevisiblei | Q6JBY9, HS |
Organism-specific databases
HPAi | ENSG00000198771, Tissue enhanced (blood, lymphoid tissue, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with CAPZA2 and CAPZB.
1 PublicationGO - Molecular functioni
- actin filament binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 124921, 8 interactors |
IntActi | Q6JBY9, 4 interactors |
STRINGi | 9606.ENSP00000356828 |
Miscellaneous databases
RNActi | Q6JBY9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 227 – 330 | RCSDAdd BLAST | 104 |
Phylogenomic databases
eggNOGi | ENOG502SRPU, Eukaryota |
GeneTreei | ENSGT00940000153997 |
HOGENOMi | CLU_039301_1_0_1 |
InParanoidi | Q6JBY9 |
OMAi | NACHPPK |
OrthoDBi | 1408738at2759 |
PhylomeDBi | Q6JBY9 |
TreeFami | TF334159 |
Family and domain databases
InterProi | View protein in InterPro IPR029341, FAM21/CAPZIP IPR007850, RCSD |
Pfami | View protein in Pfam PF15255, CAP-ZIP_m, 1 hit PF05177, RCSD, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6JBY9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEERPAETNA NVDNSASPSV AQLAGRFREQ AAAAKETPAS KPTRRKPPCS
60 70 80 90 100
LPLFPPKVDL GQNGEEKSPP NASHPPKFKV KSSPLIEKLQ ANLTFDPAAL
110 120 130 140 150
LPGASPKSPG LKAMVSPFHS PPSTPSSPGV RSRPSEAEEV PVSFDQPPEG
160 170 180 190 200
SHLPCYNKVR TRGSIKRRPP SRRFRRSQSD CGELGDFRAV ESSQQNGAKE
210 220 230 240 250
EDGDEVLPSK SKAPGSPLSS EGAAGEGVRT LGPAEKPPLR RSPSRTEKQE
260 270 280 290 300
EDRATEEAKN GEKARRSSEE VDGQHPAQEE VPESPQTSGP EAENRCGSPR
310 320 330 340 350
EEKPAGEEAE MEKATEVKGE RVQNEEVGPE HDSQETKKLE EGAAVKETPH
360 370 380 390 400
SPPGGVKGGD VPKQEKGKEK QQEGAVLEPG CSPQTGPAQL ETSSEVQSEP
410
AVPKPEDDTP VQDTKM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZKW8 | B7ZKW8_HUMAN | CapZ-interacting protein | RCSD1 | 386 | Annotation score: | ||
F6T4W9 | F6T4W9_HUMAN | CapZ-interacting protein | RCSD1 | 197 | Annotation score: |
Sequence cautioni
The sequence CAB70910 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | P → A in AAN52359 (Ref. 2) Curated | 1 | |
Sequence conflicti | 74 | H → Q in AAN52359 (Ref. 2) Curated | 1 | |
Sequence conflicti | 96 | D → E in AAN52359 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039181 | 384 | Q → R. Corresponds to variant dbSNP:rs34699420Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031648 | 1 – 310 | Missing in isoform 2. 1 PublicationAdd BLAST | 310 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY530954 mRNA Translation: AAS99235.1 AF545852 mRNA Translation: AAN52359.1 CH471067 Genomic DNA Translation: EAW90797.1 AL031733 Genomic DNA No translation available. AL356532 Genomic DNA No translation available. BC072399 mRNA Translation: AAH72399.1 BC098426 mRNA Translation: AAH98426.1 BC101536 mRNA Translation: AAI01537.1 BC101562 mRNA Translation: AAI01563.1 BC013186 mRNA Translation: AAH13186.1 AL137762 mRNA Translation: CAB70910.1 Different initiation. |
CCDSi | CCDS1263.1 [Q6JBY9-1] |
RefSeqi | NP_443094.3, NM_052862.3 [Q6JBY9-1] |
Genome annotation databases
Ensembli | ENST00000367854; ENSP00000356828; ENSG00000198771 [Q6JBY9-1] |
GeneIDi | 92241 |
KEGGi | hsa:92241 |
UCSCi | uc001gem.4, human [Q6JBY9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY530954 mRNA Translation: AAS99235.1 AF545852 mRNA Translation: AAN52359.1 CH471067 Genomic DNA Translation: EAW90797.1 AL031733 Genomic DNA No translation available. AL356532 Genomic DNA No translation available. BC072399 mRNA Translation: AAH72399.1 BC098426 mRNA Translation: AAH98426.1 BC101536 mRNA Translation: AAI01537.1 BC101562 mRNA Translation: AAI01563.1 BC013186 mRNA Translation: AAH13186.1 AL137762 mRNA Translation: CAB70910.1 Different initiation. |
CCDSi | CCDS1263.1 [Q6JBY9-1] |
RefSeqi | NP_443094.3, NM_052862.3 [Q6JBY9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124921, 8 interactors |
IntActi | Q6JBY9, 4 interactors |
STRINGi | 9606.ENSP00000356828 |
PTM databases
iPTMneti | Q6JBY9 |
PhosphoSitePlusi | Q6JBY9 |
Polymorphism and mutation databases
BioMutai | RCSD1 |
DMDMi | 74758031 |
Proteomic databases
CPTACi | CPTAC-998 |
EPDi | Q6JBY9 |
jPOSTi | Q6JBY9 |
MassIVEi | Q6JBY9 |
MaxQBi | Q6JBY9 |
PaxDbi | Q6JBY9 |
PeptideAtlasi | Q6JBY9 |
PRIDEi | Q6JBY9 |
ProteomicsDBi | 66511 [Q6JBY9-1] 66512 [Q6JBY9-2] |
Protocols and materials databases
Antibodypediai | 34342, 70 antibodies |
Genome annotation databases
Ensembli | ENST00000367854; ENSP00000356828; ENSG00000198771 [Q6JBY9-1] |
GeneIDi | 92241 |
KEGGi | hsa:92241 |
UCSCi | uc001gem.4, human [Q6JBY9-1] |
Organism-specific databases
CTDi | 92241 |
DisGeNETi | 92241 |
EuPathDBi | HostDB:ENSG00000198771.10 |
GeneCardsi | RCSD1 |
HGNCi | HGNC:28310, RCSD1 |
HPAi | ENSG00000198771, Tissue enhanced (blood, lymphoid tissue, skeletal muscle) |
MIMi | 610579, gene |
neXtProti | NX_Q6JBY9 |
OpenTargetsi | ENSG00000198771 |
PharmGKBi | PA142671088 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SRPU, Eukaryota |
GeneTreei | ENSGT00940000153997 |
HOGENOMi | CLU_039301_1_0_1 |
InParanoidi | Q6JBY9 |
OMAi | NACHPPK |
OrthoDBi | 1408738at2759 |
PhylomeDBi | Q6JBY9 |
TreeFami | TF334159 |
Enzyme and pathway databases
PathwayCommonsi | Q6JBY9 |
Miscellaneous databases
BioGRID-ORCSi | 92241, 6 hits in 844 CRISPR screens |
ChiTaRSi | RCSD1, human |
GenomeRNAii | 92241 |
Pharosi | Q6JBY9, Tbio |
PROi | PR:Q6JBY9 |
RNActi | Q6JBY9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198771, Expressed in leukocyte and 196 other tissues |
ExpressionAtlasi | Q6JBY9, baseline and differential |
Genevisiblei | Q6JBY9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029341, FAM21/CAPZIP IPR007850, RCSD |
Pfami | View protein in Pfam PF15255, CAP-ZIP_m, 1 hit PF05177, RCSD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPZIP_HUMAN | |
Accessioni | Q6JBY9Primary (citable) accession number: Q6JBY9 Secondary accession number(s): B1AK48 Q9NST4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations