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Entry version 108 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Adhesion G-protein coupled receptor V1

Gene

adgrv1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in the development of the sensory nervous system.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Hydrolase, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor V1Curated (EC:3.4.-.-By similarity)
Alternative name(s):
G-protein coupled receptor 98
Monogenic audiogenic seizure susceptibility protein 1 homolog
Very large G-protein coupled receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adgrv1
Synonyms:gpr98, mass1, vlgr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040624-6 adgrv1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 5803ExtracellularSequence analysisAdd BLAST5780
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5804 – 5824Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini5825 – 5834CytoplasmicSequence analysis10
Transmembranei5835 – 5855Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini5856 – 5864ExtracellularSequence analysis9
Transmembranei5865 – 5885Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini5886 – 5908CytoplasmicSequence analysisAdd BLAST23
Transmembranei5909 – 5929Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini5930 – 5954ExtracellularSequence analysisAdd BLAST25
Transmembranei5955 – 5975Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini5976 – 6001CytoplasmicSequence analysisAdd BLAST26
Transmembranei6002 – 6022Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini6023 – 6025ExtracellularSequence analysis3
Transmembranei6026 – 6046Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini6047 – 6199CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023273724 – 6199Adhesion G-protein coupled receptor V1Add BLAST6176

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei5785 – 5786Cleavage; by autolysisBy similarity2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6JAN0

PRoteomics IDEntifications database

More...
PRIDEi
Q6JAN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Weak expression was first detected at 20 hours post-fertilization (hpf) in the ventral diencephalon. At 24-26 hpf, expression is prominent in the prospective fore-, mid- and hindbrain including the ventral part of the epiphysis. Expression is not detected outside of the central nervous system (CNS) at this stage. At 48 hpf and 72 hpf, expression is detected in the posterior dorsal tegmentum, the mid-hindbrain boundary and in the lower rhombic lip. Expression in the eye is associated with the optic nerve. Outside the CNS, expressed in the anteriorpronephric duct.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000020853

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6JAN0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 109Calx-beta 1CuratedAdd BLAST86
Domaini126 – 230Calx-beta 2Sequence analysisAdd BLAST105
Domaini249 – 355Calx-beta 3Sequence analysisAdd BLAST107
Domaini380 – 480Calx-beta 4CuratedAdd BLAST101
Domaini637 – 737Calx-beta 5CuratedAdd BLAST101
Domaini753 – 853Calx-beta 6CuratedAdd BLAST101
Domaini869 – 972Calx-beta 7CuratedAdd BLAST104
Domaini997 – 1083Calx-beta 8Sequence analysisAdd BLAST87
Domaini1099 – 1199Calx-beta 9CuratedAdd BLAST101
Domaini1434 – 1534Calx-beta 10CuratedAdd BLAST101
Domaini1563 – 1655Calx-beta 11Sequence analysisAdd BLAST93
Domaini1835 – 1937Calx-beta 12CuratedAdd BLAST103
Domaini1963 – 2063Calx-beta 13Sequence analysisAdd BLAST101
Domaini2092 – 2190Calx-beta 14Sequence analysisAdd BLAST99
Domaini2208 – 2308Calx-beta 15Sequence analysisAdd BLAST101
Domaini2425 – 2525Calx-beta 16CuratedAdd BLAST101
Domaini2582 – 2659Calx-beta 17Sequence analysisAdd BLAST78
Domaini2673 – 2773Calx-beta 18CuratedAdd BLAST101
Domaini2814 – 2908Calx-beta 19Sequence analysisAdd BLAST95
Domaini2931 – 3029Calx-beta 20Sequence analysisAdd BLAST99
Domaini3054 – 3154Calx-beta 21CuratedAdd BLAST101
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3239 – 3284EAR 1PROSITE-ProRule annotationAdd BLAST46
Repeati3285 – 3333EAR 2PROSITE-ProRule annotationAdd BLAST49
Repeati3336 – 3372EAR 3PROSITE-ProRule annotationAdd BLAST37
Repeati3374 – 3420EAR 4PROSITE-ProRule annotationAdd BLAST47
Repeati3422 – 3467EAR 5PROSITE-ProRule annotationAdd BLAST46
Repeati3471 – 3513EAR 6PROSITE-ProRule annotationAdd BLAST43
Domaini3562 – 3605Calx-beta 22Sequence analysisAdd BLAST44
Domaini3619 – 3719Calx-beta 23CuratedAdd BLAST101
Domaini3778 – 3854Calx-beta 24Sequence analysisAdd BLAST77
Domaini3916 – 3985Calx-beta 25Sequence analysisAdd BLAST70
Domaini4000 – 4103Calx-beta 26Sequence analysisAdd BLAST104
Domaini4120 – 4220Calx-beta 27CuratedAdd BLAST101
Domaini4247 – 4335Calx-beta 28Sequence analysisAdd BLAST89
Domaini4371 – 4471Calx-beta 29Sequence analysisAdd BLAST101
Domaini4493 – 4593Calx-beta 30CuratedAdd BLAST101
Domaini4615 – 4715Calx-beta 31CuratedAdd BLAST101
Domaini4993 – 5076Calx-beta 32Sequence analysisAdd BLAST84
Domaini5125 – 5225Calx-beta 33CuratedAdd BLAST101
Domaini5260 – 5360Calx-beta 34CuratedAdd BLAST101
Domaini5748 – 5797GPSPROSITE-ProRule annotationAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUBQ Eukaryota
ENOG410XT0U LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088618

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6JAN0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6JAN0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 33 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026919 ADGRV1
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013320 ConA-like_dom_sf
IPR009039 EAR
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR006558 LamG-like
IPR003609 Pan_app

The PANTHER Classification System

More...
PANTHERi
PTHR46682 PTHR46682, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF03160 Calx-beta, 37 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 19 hits
SM00560 LamGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 38 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50912 EAR, 6 hits
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6JAN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAVLALSGL LLMLLTVSVR SESAELRFQG QTQFVVNESS RAIVRLVVER
60 70 80 90 100
VGDPINVTAL VLLQGDDTGD FEATTAAAFL LSSESSKTIF IAVKDDDIPE
110 120 130 140 150
ADETFVFILR LQSSSNGVTV GTPNTATITI LSNDNAFGII SFNSSSLITV
160 170 180 190 200
EESKGRSQYV PLTLLREKGT YGTVTVNFEI FGGPNPASED LSPDMGNITF
210 220 230 240 250
PPGRSVVVFS IMIQDDKLPE DDEIFTVQLT EAAGGALLNP NRSSVQIKIS
260 270 280 290 300
RNDAPIRFSK STLVVPENIG VISLTVTRGR TEDGLLIGSD DKTVSVAYAI
310 320 330 340 350
ITGNGAASAT PLTDFVDLQT ERMVVFLPGV HEADLRFSIR DDNIPEIAES
360 370 380 390 400
FQVVLLEETL LGDAVLVTPS LTLVTIEPND KPYGVLSISP SPIQPHIINE
410 420 430 440 450
DLNLIYEGMI IVRNGGTHGA VSVQWNITRN STDRSPVSAD LNPAAGTLRF
460 470 480 490 500
SEGQMSAVLP LNITQDSLPE EAEAFLLKLI PGSVQGGAEV DEPMEMVFFI
510 520 530 540 550
QDSDDVYGRF GFHPRENQSI QSQPEGRFLS LSFLREGGTL GEVRLTLTAL
560 570 580 590 600
YIPARPLDPS RARDGVLNGT SVNTVLFSSG QSRAQLILPI RNDAFLQNGA
610 620 630 640 650
HFRIQLDSVE LVNITPPIPS MSPRFAGALN ISLIITPDIA NGEIGFTSNQ
660 670 680 690 700
TVVALEPEDS NSSLITLQLR RDGTDGQAVV FWSLRPTGEN KEDVTKGDIS
710 720 730 740 750
PFTGSVTFLS GQSEAVINLT VLADNIPEIN ETIILTLDRT NVDNQILKPG
760 770 780 790 800
FTSREIVILE NDDPGGVFEF SPVSKGPWFI NEGETVELRV IRAQGQLLNQ
810 820 830 840 850
LIRYTVIPSG TAQFYGATGI LEFQPGEREV MVALVAKPDG IPELDETFSV
860 870 880 890 900
VLSSYSTPAS RLGNRREVNI TVRKSDDPFG VIEFIQPDLD FTINESKALG
910 920 930 940 950
CLLSILPPLE KSRGRFGNVS IFWILEPTYS GDVKPVQGEI VFAEGEYQKN
960 970 980 990 1000
LTLSSVADEI PEKTENFTIT LLNATGGARL GNILSARLSI RANDDPIYFA
1010 1020 1030 1040 1050
EPVGQRVREG GVANFTILRA GLANFVTTVN YRFEYGDTSS EDFIPESNDT
1060 1070 1080 1090 1100
MLVFHFGEWM KNISVAVVDD NIPETDEPFY IVLFNATGDA VVYGQITATV
1110 1120 1130 1140 1150
VIEANDDANG IFSLDSAQKP GEEGKTNNFY VLRDRGHFGN VTIYWQLFAN
1160 1170 1180 1190 1200
DTPLEPYQEF VNTSGFITFR TGEKTKPIVL EVISDKLPEF NEFYELRLMN
1210 1220 1230 1240 1250
VSGGYPGEGG KLANRDLNAS VLIPFNDDPF GVFAIAPDSL EREVAEDVLS
1260 1270 1280 1290 1300
VNDMTSVTSL TILRQQGTFG DVRVAWEILS GAFPRGLPPM EDLILMASFP
1310 1320 1330 1340 1350
SAVELQPHSR RRHAGTDALF FSGRPGAYGS ISAETTLLVP QILANFTLSV
1360 1370 1380 1390 1400
WLKPKPNTDG FVVSKGNGNG TVYYGVQVQT NDSHVTIMLH YTTIGSNSTH
1410 1420 1430 1440 1450
VARATANTFV EDAWVHVIIA VEDGIIEFYL DGSPIPGGIK SLKGEAIVND
1460 1470 1480 1490 1500
ATPIRIGSNP DGEQRFTGLL QDVRLYSSCL NRSQIHELHN QPAKTDLHNV
1510 1520 1530 1540 1550
SGYLTYRQEE KEKSFLVEVR DDQEAEGEEV FYLQLVAVQG GARLPMPRPT
1560 1570 1580 1590 1600
AILKVMKSDN ANGLFSFTGA CIPDIAEEGS MISCVVERTR GALDYVYVNY
1610 1620 1630 1640 1650
TVTQLDSPAD LSNASDFANA TGFILFQPGQ LSEVLNLLVV NDDLPEVDEH
1660 1670 1680 1690 1700
FRVRLVSAKS GDGKPGSTPT SGASIDPEKA VNNVTVKASD HPYGLLQFQT
1710 1720 1730 1740 1750
TPVPVGMIRP ALEEARVTVQ EEAGVVRLLV ARAQGLLGRV MVGYRTSPFT
1760 1770 1780 1790 1800
AAGSEDYEGF LDFLPGERFK YINVTIIDNS VPELDKVFRV ELYNPNGGVD
1810 1820 1830 1840 1850
PYFASEGSGS GESETDFFLP SFHYHHANLG AAARIIVTIA ASDEAHGVFQ
1860 1870 1880 1890 1900
FGADSLIVNG TEPEEGRSTV VLQVIRTFGA LSNVTVYWEA DAASEGELVY
1910 1920 1930 1940 1950
RSGNVNFEVG QTVRSIYLLI SQDDVPELDK TFKVRLTNAS HGRLGKETTA
1960 1970 1980 1990 2000
TLTVLASDDP YGLFVFSDNT RPVRVAEANA LVALTIQRRK GLMGRVRVAY
2010 2020 2030 2040 2050
RTLRDTDTVL YSTPGVGRAS EGNDFIAVVD SVIFSANQSE VNVTLRVLDD
2060 2070 2080 2090 2100
NEPERAESVF LELVSVTLIE GLQPRPVALS PRLGPRNVTI AQVIIEASDD
2110 2120 2130 2140 2150
AFGVLQLSSS AVSVPEYYTG PIINVTRIGG IFADVSVKFR AVPLTARVGE
2160 2170 2180 2190 2200
DYRVASSDVV LLEGESSKPV PILIINDVVP ELEETFRIEL LNQTTGGALL
2210 2220 2230 2240 2250
GDLTQAIITI LPSDDPFGLF VFQAAPITIE EPALTAFEVS VPIVRNAGTM
2260 2270 2280 2290 2300
GDVAVQWRAT VNGRPATGDL RPVSGEVMFS PGETLKTLKV EVLPDDVPEI
2310 2320 2330 2340 2350
EEIIKVELVS ATSGGNIGLE KVVDTIVPAN DNPHGTVYFE QAVYRVQEPL
2360 2370 2380 2390 2400
EGIYIANVTI RRSGGNFGML EVVYSTLEVD IVSNALKEGR NFLVYYDSRL
2410 2420 2430 2440 2450
AGVPSNAIRR PINITTSTNV LNFCAAFCLR ERACQAFSFT NTTTPSCFWV
2460 2470 2480 2490 2500
TSGVSQLSPS PQTFTYLKNT TATASLFSSQ AVAGSDFITM TAQTTTMLDG
2510 2520 2530 2540 2550
SGVANLTVPI LTDSLPEMDE SFIIKILKVS LVNVTATARN LPTIRQPDTA
2560 2570 2580 2590 2600
LVTIGMNGDA FGIFLLYSIN PNATQEGLYL EVREEPKTTV LLVIERRGGS
2610 2620 2630 2640 2650
MGQVTVEWKY VGGSATPNAD FNGTGETLIF AEGDVKKTLE FIITDDTEPE
2660 2670 2680 2690 2700
NNETLQIGLV STEGGSRILP SSDTVTILIL ANDNAAGVVG FHTASRSRIV
2710 2720 2730 2740 2750
REGESVTLLV ERTAPAIGNV AVDWRIEGPL VPTTFADTSG TLFFSEGILN
2760 2770 2780 2790 2800
NTIVLKLLED TTPEDREEYR VILSNIQTTG VTKTGIAALS AQGREAVVSV
2810 2820 2830 2840 2850
EASDEPFGLL SIAPSSLQVT TDEKNTTIRI YINREFGASG AVNISYETVR
2860 2870 2880 2890 2900
GSLQDLRQTE GALAQPGQDF RYVSNSVIMQ DGQTSVSIPI TIIDDDIPEL
2910 2920 2930 2940 2950
QEFFLVNITS AVLITTLPTA PKLNTEGLVA EIIINANDGI RGIIGWQNID
2960 2970 2980 2990 3000
YVVNETIGVL TLVAYRDAGT YGNVSLFFYA QNLEAQLGLD FNATPSMIYF
3010 3020 3030 3040 3050
VDGERHKFIE VQILDDAVPE GGETFQLILA NPSAGLQLGE NTTATVMILA
3060 3070 3080 3090 3100
NDDGHGIISF NNSEHFLLRE PTSVSGLGTS VATLYIIRDP PQGTFGTVTV
3110 3120 3130 3140 3150
QFTITDVNGS LYTDDLTPSS GFVVLEDGVR YKTLEIWAVL DAEPEMNETF
3160 3170 3180 3190 3200
TVTLSNPTGG ARLGVSLQTF ITVLENQAPL GLFRISPSIN RTLDTMTVEE
3210 3220 3230 3240 3250
HMGTVFLTVS RSNGLESAVS VEWETRSGTA FGMRGEQPVL AVYQSIRDSF
3260 3270 3280 3290 3300
ASVWCSVPSG DAALVLRLIK GLTQNQTVLY KWQGVFVPVE FVSIQNPKSC
3310 3320 3330 3340 3350
VGFTVNGSSY VAVSHADNTV SLTTNISLFR VQADLNLTLE QTFSVSGFSV
3360 3370 3380 3390 3400
KHFSTDLKQY LIASSEIFVW NRGSFFLHQS LELQDIIAAV PFRRGSSNVQ
3410 3420 3430 3440 3450
HLAVCRNRTS AACFIYQWTD GRFQNPQPLA LNTEVKQVES HQMGGDTFLF
3460 3470 3480 3490 3500
IVTEGLNPAC EVFLWGSQQT VFQQTQSILV PGLFSVHPFT TPSGIFHLLL
3510 3520 3530 3540 3550
AGVNGSALYS WRSELRQFAE MLKSASAQEF LYLPVPSINS PKSLILASGK
3560 3570 3580 3590 3600
SSSLVYELTS VSNQSDFIPS SGELFFQPGV QELEIAVNVI DDDVPEEEEH
3610 3620 3630 3640 3650
FRVSLKNPKG GAEIGFRGQV TFFIPANDDT YGIIGFSQNS LMREVEELQS
3660 3670 3680 3690 3700
DNPVSLSIER RRGRFGRLTV HWSAYGSLDD IFPTSGVVTF SESQAVATIS
3710 3720 3730 3740 3750
LNVLADDIPE LAEKVTIVLT KVTTIGIIDP SRGASIDYQR AQANLTIRAN
3760 3770 3780 3790 3800
GSPYGVIGWH LDSQYFITPE PQKSPSNITL SIVRDQGSSG NVLVYYSTKP
3810 3820 3830 3840 3850
ALHLLPLNQA SGGTDYVAKE ATVVMMENAT VVLVFLTILP DDIPELAETF
3860 3870 3880 3890 3900
FVNITRVEVL GGDTGAAQPS VKRPGLEIAE VTIQENDDPR GVLSFNVSKD
3910 3920 3930 3940 3950
VSGAVLAFEV PSPGNVLRLA VMRMAGIFGR LVLYWETQSV TASTEDFTPS
3960 3970 3980 3990 4000
SGNITFQDGQ AMAYIEITII DDTIVESTET FMVKLIRVIG GARLGVETSV
4010 4020 4030 4040 4050
VVSIPANDSP FGRFGFEELK VSVSEPQFLN DPASVATLTV VRSSGGEGVV
4060 4070 4080 4090 4100
HLIWLLQEES RDDLSPRNGT LIFNGTESKK TLVIQALADA VLEGEESFTI
4110 4120 4130 4140 4150
QLLSPKNEPV IDPVRGVATV VIRPDVGALG TVGIADSSRN VLIGEPICSY
4160 4170 4180 4190 4200
NGTALISLIR GPGIFGEIEI FWNITTAAVS EFEETSGKVV MKDRQSAATI
4210 4220 4230 4240 4250
QLKALDDEIP EERRVYQLRL SSLTPGSVIN PDRQFASITM AASDLPHGLF
4260 4270 4280 4290 4300
SFSQASLRAT EEDRAVNVTI VRSMGLFGSV WVSFHTEGRT AISGQDFGQS
4310 4320 4330 4340 4350
SGRPLFRPGE SSRVIPLVIF DDDLPEGPEE FFLNITLVEL LNASSMDFTV
4360 4370 4380 4390 4400
REYGLQIDQP PAIGNLSSLM VIIQKNDNAE GILEFDPKYV NNTVEEDVGT
4410 4420 4430 4440 4450
LSIPVLRRVG SYGQVTVQFV SKGLTAQPDS DYILLNGSIT FQHGQTLSYI
4460 4470 4480 4490 4500
NVSIVDDTES EFNEIFELQL TGATGGAILG AQLIARITIA KSDSPNGVVR
4510 4520 4530 4540 4550
FINQSAITIP NPNSTVRLSL FAERADGLLG DATVMWHIQG PNSNEVLPSM
4560 4570 4580 4590 4600
NTDIEPVNGT FSFRDGEGGV RSIDLKILPH GEVEVTEKFI IMLSVISGEM
4610 4620 4630 4640 4650
GVDPRAGSVT LTIEKFGDPN GIVQFTEQDL KERIYSEPSD SEGPLKVSVL
4660 4670 4680 4690 4700
VTRREGVMGN ITVFWEILSD ADTSGDFAAL RGSVIILAGQ RLAEIILTLL
4710 4720 4730 4740 4750
PDSVPELEET YTLRLTSVEG GAELDLNRSS TRLKVRANDE PHGVFVMYSQ
4760 4770 4780 4790 4800
NQSVVVNAAD RSRQLIISVN RLAGAFGNAS VGYRISFTTP GQSFTEDTIT
4810 4820 4830 4840 4850
GNILVKDGER EASIRVPVSS QVFFVTGFNF SVELTDVTLI GPLLGSPPRI
4860 4870 4880 4890 4900
QLESKLAVVS VPEVAANPVV GFASLALRVL DIESGQCEAL VTRTGLYGNI
4910 4920 4930 4940 4950
TVRWSSGFPP GQTPPGYQPG EILPRSGSIM LAHGQRSELI SFTALNNISV
4960 4970 4980 4990 5000
VTAHAIYLTS VESESPGGAR LRTGYTVAEV EPLGLYQFHP NSQHLVIEED
5010 5020 5030 5040 5050
VQTITLYVQR FYGFRSNRSS VSYRTWPGTA QPDKDYVPVT DGQLLFDSRQ
5060 5070 5080 5090 5100
TSASIRLSIL DDTLTEPDED FYVNLTSVRV LSTTLPLITA QPGIVQKNSI
5110 5120 5130 5140 5150
STVTIRANDV VSGFLSIGPA VKLISEDSVE DSPQQKLQLR VRRTAGLSGV
5160 5170 5180 5190 5200
VSAKIRAYAG LKTPLVDASQ FHREHKGTWA LEGEDFALET QSVTLLEGQN
5210 5220 5230 5240 5250
EVEVTVIMLN DQEPEGQEAF FIYLSDAEGG AQIVSVPDEL GFTSFAKIII
5260 5270 5280 5290 5300
LGSDLQNGIV GFSLSSLSGQ VLDEDSVNRT VTLVLQRQEN RAFEDVLVFW
5310 5320 5330 5340 5350
RVTFSTTDHA LVSHGVDLSK ELLQTSGTSI RRKGEVLCAL KLEVQPDKNP
5360 5370 5380 5390 5400
EYEVWFLVEV YKVGEGAAIN QTARFANITM LESDDPRGLV YFAQGSRLPV
5410 5420 5430 5440 5450
VTLKATSVSL QIYRDASTAS SISVEYRMQE LPKVESIGPS LVWPAVAGQD
5460 5470 5480 5490 5500
FVMSEGTLTF EIGQSSAGLN IDLTPNIGSS NLTPKRFQVV LSDATGGARV
5510 5520 5530 5540 5550
HPEFGLANVT LVSDTETQAV WALLDQLHQP LEETIINRVL HALINKVSRD
5560 5570 5580 5590 5600
ITPEQLMAVL DASSKILSDA EQTPLKDSSR GLTYDLLCAM ANPNRTDTQG
5610 5620 5630 5640 5650
VSQLSEVAER FAYSLLTDIK CGAEGKRGIT ILDNCPYFTI AAHHWYPMQI
5660 5670 5680 5690 5700
NGHTFIGKNT DTFTLPETLL EVPALPADST APSACYKVHF TEYSTEHWFL
5710 5720 5730 5740 5750
TNKKPSALNG KVFSVSLYGR GSKPLSEGQE VVYRIHTPDR RGKPKPSQSL
5760 5770 5780 5790 5800
CLLWNQAAES WLSDGQFCRL VDDTQNYVEC ACSHLSIYTA YAEIESLASF
5810 5820 5830 5840 5850
NEAFYAAGFI CISGFALAMV SHLMCARFLM FAAKLLTHMM VACLGTQICF
5860 5870 5880 5890 5900
LVSAFRGRMF SEDSCAALGL FFHYFHLSQF GWMLVQAINF WQILVMNDEH
5910 5920 5930 5940 5950
TERRYLLYFL LSWGLPALVI IVLVVVLLGG FGWSIHSVYG LVQGDLCFIP
5960 5970 5980 5990 6000
NVYAALCTAA LVPLICLVGV LVIFIHAYQV TQQWKAYDDI YRGRTNSSEV
6010 6020 6030 6040 6050
PMMLYLFALV TLVCVWAGLH MAYRYIWMLI LLVIFNIFLG LYVFSVYFVM
6060 6070 6080 6090 6100
HNQLFWPGKA TYTVEMNGHS SPDSIYQSTG AATVGGGEIS KSTQNLISAM
6110 6120 6130 6140 6150
EEISADWERA SLRPSSQPSS IFKPSPQDEA YITEGGFINT SLVRDEESQE
6160 6170 6180 6190
FDDLIFALKT GSGLNVSDNE SIHGSHDGGS MANSQIVELR RIPIADTHL
Length:6,199
Mass (Da):674,630
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i893D5E4E933CD055
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QEZ1F1QEZ1_DANRE
Adhesion G-protein-coupled receptor...
adgrv1
6,198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY540131 mRNA Translation: AAT07468.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540131 mRNA Translation: AAT07468.1

3D structure databases

SMRiQ6JAN0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020853

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

PaxDbiQ6JAN0
PRIDEiQ6JAN0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-040624-6 adgrv1

Phylogenomic databases

eggNOGiENOG410IUBQ Eukaryota
ENOG410XT0U LUCA
HOGENOMiHOG000088618
InParanoidiQ6JAN0
PhylomeDBiQ6JAN0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6JAN0

Family and domain databases

Gene3Di2.60.40.2030, 33 hits
InterProiView protein in InterPro
IPR026919 ADGRV1
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013320 ConA-like_dom_sf
IPR009039 EAR
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR006558 LamG-like
IPR003609 Pan_app
PANTHERiPTHR46682 PTHR46682, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF03160 Calx-beta, 37 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 19 hits
SM00560 LamGL, 1 hit
SUPFAMiSSF141072 SSF141072, 38 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 6 hits
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRV1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6JAN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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