Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 75 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Non-structural polyprotein pORF1

Gene

ORF1

Organism
Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase: Displays a capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m7GTP or m7GDP. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m7GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure.By similarity
Papain-like cysteine protease: May participate in the processing of polyprotein pORF1 together with cellular proteases and the cleavage of capsid protein ORF2.By similarity
NTPase/helicase: Multi-functional protein that exhibits NTPase and RNA unwinding activities. Hydrolyzes all NTPs efficiently and unwinds RNA duplexes containing 5' overhangs. Possesses a sequence independent RNA-5'-triphosphatase (RTPase) activity suggestive of its role in forming viral cap structure (By similarity). Participates also in viral genome replication, RNA translocation and genome packaging/unpackaging (By similarity).By similarity
RNA-directed RNA polymerase: Plays an essential role in the virus replication. Binds to the 3'-end of the genomic RNA to initiate viral replication.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi990 – 997ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Methyltransferase, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-structural polyprotein pORF1
Including the following 4 domains:
Methyltransferase (EC:2.1.1.-, EC:2.7.7.-)
Putative papain-like cysteine protease (EC:3.4.22.-)
Short name:
PLP
NTPase/helicase (EC:3.6.4.-)
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri512345 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaAlsuviricetesHepeliviralesHepeviridaeOrthohepevirusOrthohepevirus A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBandicota bengalensis (lesser bandicoot rat) [TaxID: 69079]
Callithrix [TaxID: 9481]
Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey) [TaxID: 9536]
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Mus musculus (Mouse) [TaxID: 10090]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
Saimiri (squirrel monkeys) [TaxID: 9520]
Sus scrofa (Pig) [TaxID: 9823]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001028 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008989 Componenti: Genome
  • UP000008859 Componenti: Genome
  • UP000008858 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50000550291 – 1708Non-structural polyprotein pORF1Add BLAST1708

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

It is not yet clear whether the ORF1-encoded polyprotein contains multiple biochemical activities, or undergoes cis or trans- processing to release biochemically distinct peptides. No processing has been observed in mammalian expression systems. However, the baculovirus expressed polyprotein is processed into smaller protein, probably by a cysteine protease.

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6J8G2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6J8G2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 240Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST185
Domaini790 – 936MacroPROSITE-ProRule annotationAdd BLAST147
Domaini949 – 1097(+)RNA virus helicase ATP-bindingAdd BLAST149
Domaini1098 – 1231(+)RNA virus helicase C-terminalAdd BLAST134
Domaini1469 – 1580RdRp catalyticPROSITE-ProRule annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 240MethyltransferaseBy similarityAdd BLAST181
Regioni239 – 439Y-domainBy similarityAdd BLAST201
Regioni440 – 610Putative papain-like cysteine proteaseBy similarityAdd BLAST171
Regioni714 – 793HingeBy similarityAdd BLAST80
Regioni800 – 957X-domainBy similarityAdd BLAST158
Regioni975 – 1219NTPase/helicaseBy similarityAdd BLAST245
Regioni1222 – 1708RNA-directed RNA polymeraseBy similarityAdd BLAST487

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi716 – 789Pro-richAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR008748, Hepatitis-E_Cys-pept
IPR022202, Hepatitis-E_hinge
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR027417, P-loop_NTPase
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12526, DUF3729, 1 hit
PF05417, Peptidase_C41, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6J8G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQQFIKAP GITTAIEQAA LAAANSALAN AVVVRPFLSR VQTEILINLM
60 70 80 90 100
QPRQLVFRPE VLWNHPIQRV IHNELEQYCR ARAGRCLEVG AHPRSINDNP
110 120 130 140 150
NVLHRCFLRP VGRDVQRWYS APTRGPAANC RRSALRGLPP VDRTYCFDGF
160 170 180 190 200
SRCAFAAETG VALYSLHDLW PADVAEAMAR HGMTRLYAAL HLPPEVLLPP
210 220 230 240 250
GTYHTTSYLL IHDGDRAVVT YEGDTSAGYN HDVSILRAWI RTTKIVGDHP
260 270 280 290 300
LVIERVRAIG CHFVLLLTAA PEPSPMPYVP YPRSTEVYVR SIFGPGGSPS
310 320 330 340 350
LFPSACSTKS TFHAVPVHIW DRLMLFGATL DDQAFCCSRL MTYLRGISYK
360 370 380 390 400
VTVGALVANE GWNASEDALT AVITAAYLTI CHQRYLRTQA ISKGMRRLEV
410 420 430 440 450
EHAQKFITRL YSWLFEKSGR DYIPGRQLQF YAQCRRWLSA GFHLDPRVLV
460 470 480 490 500
FDESVPCRCR TFLKKVAGKF CCFMRWLGQE CTCFLEPAEG LVGDYGHDNE
510 520 530 540 550
AYEGSEVDPA EPAHLDVSGT YAVHGRQLEA LYRALNVPHD IAARASRLTA
560 570 580 590 600
TVELTASPDR LECRTVLGNK TFRTTVVDGA HLEANGPEQY VLSFDASRQS
610 620 630 640 650
MGAGSHSLTY ELTPAGLQVR ISSNGLDCTA TFPPGGAPSA APGEVAAFCS
660 670 680 690 700
ALYRYNRFTQ RHSLTGGLWL HPEGLLGIFP PFSPGHIWES ANPFCGEGTL
710 720 730 740 750
YTRTWSTSGF SSDFSPPEAA APVLAAAPGL PHPTPPVSDI WVLPPPSEES
760 770 780 790 800
QVDAASVPPA PEPAGLPSSI VLTLPPPLPP VRKPPTPPPS RTRRLLYTYP
810 820 830 840 850
DGAKVYAGSL FESDCNWLVN ASNPGHRPGG GLCHAFYQRF PEAFYPTEFI
860 870 880 890 900
MREGLAAYTL TPRPIIHAVA PDYRVEQNPK RLEAAYRETC SRRGTAAYPL
910 920 930 940 950
LGSGIYQVPV SLSFDAWERN HRPGDELYLT EPAAAWFEAN KPAQPALTIT
960 970 980 990 1000
EDTARTANLA LEIDAATDVG RACAGCTISP GIVHYQFTAG VPGSGKSRSI
1010 1020 1030 1040 1050
QQGDVDVVVV PTRELRNSWR RRGFAAFTPH TAARVTIGRR VVIDEAPSLP
1060 1070 1080 1090 1100
PHLLLLHMQR ASSVHLLGDP NQIPAIDFEH AGLVPAIRPE LAPTSWWHVT
1110 1120 1130 1140 1150
HRCPADVCEL IRGAYPKIQT TSRVLRSLFW NEPAIGQKLV FTQAAKAANP
1160 1170 1180 1190 1200
GAITVHEAQG ATFTETTIIA TADARGLIQS SRAHAIVALT RHTEKCVILD
1210 1220 1230 1240 1250
APGLLREVGI SDVIVNNFFL AGGEVGHHRP SVIPRGNPDQ NLGTLQAFPP
1260 1270 1280 1290 1300
SCQISAYHQL AEELGHRPAP VAAVLPPCPE LEQGLLYMPQ ELTVSDSVLV
1310 1320 1330 1340 1350
FELTDIVHCR MAAPSQRKAV LSTLVGRYGR RTKLYEAAHS DVRESLARFI
1360 1370 1380 1390 1400
PTIGPVQATT CELYELVEAM VEKGQDGSAV LELDLCNRDV SRITFFQKDC
1410 1420 1430 1440 1450
NKFTTGETIA HGKVGQGISA WSKTFCALFG PWFRAIEKEI LALLPPNIFY
1460 1470 1480 1490 1500
GDAYEESVFA AAVSGAGSCM VFENDFSEFD STQNNFSLGL ECVVMEECGM
1510 1520 1530 1540 1550
PQWLIRLYHL VRSAWILQAP KESLKGFWKK HSGEPGTLLW NTVWNMAIIA
1560 1570 1580 1590 1600
HCYEFRDFRV AAFKGDDSVV LCSDYRQSRN AAALIAGCGL KLKVDYRPIG
1610 1620 1630 1640 1650
LYAGVVVAPG LGTLPDVVRF AGRLSEKNWG PGPERAEQLR LAVCDFLRGL
1660 1670 1680 1690 1700
TNVAQVCVDV VSRVYGVSPG LVHNLIGMLQ TIADGKAHFT ETIKPVLDLT

NSIIQRVE
Length:1,708
Mass (Da):187,395
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB1C6A04193571BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4Q → H in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti70V → A in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti85R → C in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti95S → F in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti193P → L in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti690S → P in AAC97208 (PubMed:9811705).Curated1
Sequence conflicti748E → K in AAC97208 (PubMed:9811705).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF082843 Genomic RNA Translation: AAC97208.1
AY575857 Genomic RNA Translation: AAT40994.1
AY575858 Genomic RNA Translation: AAT40997.1
AY575859 Genomic RNA Translation: AAT41000.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082843 Genomic RNA Translation: AAC97208.1
AY575857 Genomic RNA Translation: AAT40994.1
AY575858 Genomic RNA Translation: AAT40997.1
AY575859 Genomic RNA Translation: AAT41000.1

3D structure databases

SMRiQ6J8G2
ModBaseiSearch...

Proteomic databases

PRIDEiQ6J8G2

Family and domain databases

Gene3Di3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR008748, Hepatitis-E_Cys-pept
IPR022202, Hepatitis-E_hinge
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR027417, P-loop_NTPase
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF12526, DUF3729, 1 hit
PF05417, Peptidase_C41, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLN_HEVMG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6J8G2
Secondary accession number(s): Q9YK10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again