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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

clk-1

Organism
Apis mellifera ligustica (Common honeybee) (Italian honeybee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Iron 1UniRule annotation1
Metal bindingi68Iron 1UniRule annotation1
Metal bindingi68Iron 2UniRule annotation1
Metal bindingi71Iron 1UniRule annotation1
Metal bindingi120Iron 2UniRule annotation1
Metal bindingi156Iron 1UniRule annotation1
Metal bindingi156Iron 2UniRule annotation1
Metal bindingi159Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processUbiquinone biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, UbiquinoneImported

Enzyme and pathway databases

UniPathwayi
UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:clk-1Imported
Synonyms:coq7UniRule annotation
OrganismiApis mellifera ligustica (Common honeybee) (Italian honeybee)Imported
Taxonomic identifieri7469 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6J4P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Phylogenomic databases

KOiK06134

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

Q6J4P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHLRQYGIR LASTSAISGT TKPGKLLDSI IRVDHAGELG ADRIYAGQMA
60 70 80 90 100
VLGRTSVGPT IQHMWDQEKK HRAKFEELIT KYRVRPTVLI PIWNVAGFIL
110 120 130 140 150
GAGTALMGEK AAMACTVAVE TVITEHYNDQ LRALVENEEK VDEEILETIK
160 170 180 190
KFRDEEQEHH DTGIEYGAEQ APFYQALTNI IKFGCKTAIS ISKVI
Length:195
Mass (Da):21,737
Last modified:July 5, 2004 - v1
Checksum:i93AF66457DD37036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601644 mRNA Translation: AAT12412.1
RefSeqiNP_001171538.1, NM_001178067.1
UniGeneiAme.4784
Ame.6212

Genome annotation databases

GeneIDi409224
KEGGiame:409224

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601644 mRNA Translation: AAT12412.1
RefSeqiNP_001171538.1, NM_001178067.1
UniGeneiAme.4784
Ame.6212

3D structure databases

ProteinModelPortaliQ6J4P7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi409224
KEGGiame:409224

Organism-specific databases

CTDi10229

Phylogenomic databases

KOiK06134

Enzyme and pathway databases

UniPathwayi
UPA00232

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6J4P7_APILI
AccessioniPrimary (citable) accession number: Q6J4P7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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