SLC8B1

Functionⁱ

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca²⁺ entry (SOCE) and Ca²⁺ release-activated Ca²⁺ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca²⁺ in exchange of either Li⁺ or Na⁺, explaining how Li⁺ catalyzes Ca²⁺ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K⁺ (PubMed:15060069).By similarity6 Publications

Activity regulationⁱ

Inhibited by the sodium/calcium exchanger inhibitor CGP-37157 (PubMed:24898248). Strongly inhibited by zinc (PubMed:15060069).2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium export from the mitochondrion
Source: UniProtKB
Inferred from direct assayⁱ
- 24898248
glucose homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 23056385
ion transport Source: Reactome
mitochondrial calcium ion homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 24898248
mitochondrial calcium ion transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 23056385
- 24898248
regulation of cardiac muscle cell membrane potential
Source: BHF-UCL
Traceable author statementⁱ
- 20018762
regulation of cytosolic calcium ion concentration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20018762
regulation of insulin secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 23056385
regulation of lymphocyte chemotaxis Source: UniProtKB
regulation of store-operated calcium entry
Source: UniProtKB
Inferred from direct assayⁱ
- 28219928
response to stimulus Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Antiport, Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport
Ligand	Calcium, Lithium, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-425561 Sodium/Calcium exchangers R-HSA-8949215 Mitochondrial calcium ion transport

Reactomeⁱ

R-HSA-425561 Sodium/Calcium exchangers
R-HSA-8949215 Mitochondrial calcium ion transport

Protein family/group databases

TCDBⁱ	2.A.19.4.4 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.4.4 the ca(2+):cation antiporter (caca) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial sodium/calcium exchanger proteinCurated Alternative name(s): Na(+)/K(+)/Ca(2+)-exchange protein 6By similarity Sodium/calcium exchanger protein, mitochondrial1 Publication Sodium/potassium/calcium exchanger 6By similarity Solute carrier family 24 member 6Imported Solute carrier family 8 member B1Imported
Gene namesⁱ	Name:SLC8B1Imported Synonyms:NCKX6By similarity, NCLX1 Publication, SLC24A6Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089060.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26175 SLC8B1
MIMⁱ	609841 gene
neXtProtⁱ	NX_Q6J4K2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 95	ExtracellularSequence analysisAdd BLAST	69
Transmembraneⁱ	96 – 116	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	117 – 140	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	141 – 161	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	162 – 168	ExtracellularSequence analysis	7
Transmembraneⁱ	169 – 189	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	190 – 200	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	201 – 221	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	222 – 226	ExtracellularSequence analysis	5
Transmembraneⁱ	227 – 247	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	248 – 325	CytoplasmicSequence analysisAdd BLAST	78
Transmembraneⁱ	326 – 346	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	347 – 360	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	361 – 381	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	382 – 383	CytoplasmicSequence analysis	2
Transmembraneⁱ	384 – 404	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	405 – 416	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	417 – 437	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	438 – 445	CytoplasmicSequence analysis	8
Transmembraneⁱ	446 – 466	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	467 – 487	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	488 – 508	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	509 – 524	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	525 – 545	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	546 – 558	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	559 – 579	Helical; Name=13Sequence analysisAdd BLAST	21
Topological domainⁱ	580 – 584	CytoplasmicSequence analysis	5

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	258	S → A: Abolished ability to prevent calcium overload. 1 Publication		1
Mutagenesisⁱ	258	S → D: Phosphomimetic mutant; prevents calcium overload. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80024
Open Targets More...OpenTargetsⁱ	ENSG00000089060
PharmGKBⁱ	PA134954965

Chemistry databases

ChEMBLⁱ	CHEMBL3763001

ChEMBLⁱ

CHEMBL3763001

Polymorphism and mutation databases

BioMutaⁱ	SLC24A6
DMDMⁱ	85681048

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 26	MitochondrionSequence analysisAdd BLAST		26
ChainⁱPRO_0000045756	27 – 584	Mitochondrial sodium/calcium exchanger proteinAdd BLAST		558

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	60	N-linked (GlcNAc...) asparagineSequence analysis		1
Modified residueⁱ	258	Phosphoserine; by PKA1 Publication		1

Post-translational modificationⁱ

Phosphorylation at Ser-258 by PKA prevents calcium overload.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6J4K2
PaxDbⁱ	Q6J4K2
PeptideAtlas More...PeptideAtlasⁱ	Q6J4K2
PRIDEⁱ	Q6J4K2
ProteomicsDBⁱ	66508 66509 [Q6J4K2-2]

PTM databases

iPTMnetⁱ	Q6J4K2
PhosphoSitePlusⁱ	Q6J4K2

Expressionⁱ

Tissue specificityⁱ

Present in pancreatic beta-cells (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000089060 Expressed in 185 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_SLC24A6
ExpressionAtlasⁱ	Q6J4K2 baseline and differential
Genevisibleⁱ	Q6J4K2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040668

HPAⁱ

HPA040668

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20018762

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123078, 2 interactors
IntActⁱ	Q6J4K2, 1 interactor
STRINGⁱ	9606.ENSP00000202831

Chemistry databases

BindingDBⁱ

Q6J4K2

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6J4K2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. [View classification]Curated

Keywords - Domainⁱ

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2399 Eukaryota COG0530 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119209
HOGENOMⁱ	HOG000113743
HOVERGENⁱ	HBG082009
InParanoidⁱ	Q6J4K2
KEGG Orthology (KO) More...KOⁱ	K13754
OMAⁱ	AHISPQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05GE
PhylomeDBⁱ	Q6J4K2
TreeFamⁱ	TF323444

Family and domain databases

InterProⁱ	View protein in InterPro IPR004837 NaCa_Exmemb
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01699 Na_Ca_ex, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6J4K2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV 
        60         70         80         90        100
VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV 
       110        120        130        140        150
TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG 
       160        170        180        190        200
APDIFSALVA FSDPHTAGLA LGALFGAGVL VTTVVAGGIT ILHPFMAASR 
       210        220        230        240        250
PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY VVTVILCTWI 
       260        270        280        290        300
YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET 
       310        320        330        340        350
TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD 
       360        370        380        390        400
DQNWKRPLNC LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA 
       410        420        430        440        450
LASVTFFATS DSQPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVV 
       460        470        480        490        500
FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL 
       510        520        530        540        550
VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF SLVSVPLQCF 
       560        570        580 
QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM

Length:584

Mass (Da):64,231

Last modified:January 10, 2006 - v2

Checksum:ⁱ6B7008661CC12872

GO

Isoform 2 (identifier: Q6J4K2-2) [UniParc]FASTA Add to basket

Also known as: S-NCLX1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
176-231: Missing.

« Hide

        10         20         30         40         50
MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV 
        60         70         80         90        100
VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV 
       110        120        130        140        150
TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG 
       160        170        180        190        200
APDIFSALVA FSDPHTAGLA LGALFGYLGL YVFYVVTVIL CTWIYQRQRR 
       210        220        230        240        250
GSLFCPMPVT PEILSDSEED RVSSNTNSYD YGDEYRPLFF YQETTAQILV 
       260        270        280        290        300
RALNPLDYMK WRRKSAYWKA LKVFKLPVEF LLLLTVPVVD PDKDDQNWKR 
       310        320        330        340        350
PLNCLHLVIS PLVVVLTLQS GTYGVYEIGG LVPVWVVVVI AGTALASVTF 
       360        370        380        390        400
FATSDSQPPR LHWLFAFLGF LTSALWINAA ATEVVNILRS LGVVFRLSNT 
       410        420        430        440        450
VLGLTLLAWG NSIGDAFSDF TLARQGYPRM AFSACFGGII FNILVGVGLG 
       460        470        480        490        500
CLLQISRSHT EVKLEPDGLL VWVLAGALGL SLVFSLVSVP LQCFQLSRVY 
       510        520 
GFCLLLFYLN FLVVALLTEF GVIHLKSM

Show »

Length:528

Mass (Da):58,087

Checksum:ⁱA1B30D288E0B7B47

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VR99	F8VR99_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	231	Annotation score:
H0YI75	H0YI75_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	404	Annotation score:
F8VW44	F8VW44_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	143	Annotation score:
A0A0B4J252	A0A0B4J252_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	99	Annotation score:
F8VWW9	F8VWW9_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	131	Annotation score:
F8VTU4	F8VTU4_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	103	Annotation score:
F8W134	F8W134_HUMAN	Mitochondrial sodium/calcium exchan... Mitochondrial sodium/calcium exchanger protein	SLC8B1	53	Annotation score:

Sequence cautionⁱ

The sequence BAB15271 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	57	C → R in AAT35807 (PubMed:15060069).Curated	1
Sequence conflictⁱ	130	S → P in AAT35807 (PubMed:15060069).Curated	1
Sequence conflictⁱ	281	N → S in AAT35807 (PubMed:15060069).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050224	222	R → C. Corresponds to variant dbSNP:rs16942745Ensembl.		1
Natural variantⁱVAR_050225	358	L → F. Corresponds to variant dbSNP:rs3764034Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016996	176 – 231	Missing in isoform 2. 1 PublicationAdd BLAST		56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY601759 mRNA Translation: AAT35807.1 AY601760 mRNA Translation: AAT35808.1 AC010178 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW98050.1 BC098360 mRNA Translation: AAH98360.1 AK025886 mRNA Translation: BAB15271.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31909.1 [Q6J4K2-1] CCDS81744.1 [Q6J4K2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317395.1, NM_001330466.1 [Q6J4K2-2] NP_079235.2, NM_024959.3 [Q6J4K2-1] XP_006719670.1, XM_006719607.2 XP_011537051.1, XM_011538749.2 XP_011537054.1, XM_011538752.2
UniGeneⁱ	Hs.286194

Genome annotation databases

Ensemblⁱ	ENST00000202831; ENSP00000202831; ENSG00000089060 [Q6J4K2-1] ENST00000546737; ENSP00000450081; ENSG00000089060 [Q6J4K2-2] ENST00000552014; ENSP00000447091; ENSG00000089060 [Q6J4K2-1]
GeneIDⁱ	80024
KEGGⁱ	hsa:80024
UCSC genome browser More...UCSCⁱ	uc001tvc.4 human [Q6J4K2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6J4K2	Mitochondrial sodium/calcium exchanger protein (Fragment)		HUMAN		131	UniRef100_Q6J4K2
Mitochondrial sodium/calcium exchanger protein (Fragment)		HUMAN		231
Mitochondrial sodium/calcium exchanger protein (Fragment)		HUMAN		103
UPI0000071A96		HUMAN		389

Protein	Similar proteins		Species	Score	Length	Source
Q6J4K2	Mitochondrial sodium/calcium exchanger protein (Fragment)		HUMAN		131	UniRef90_Q6J4K2
Uncharacterized protein		MANLE		593
Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 6		PANTR		584
Uncharacterized protein		PANPA		584
Sodium/potassium/calcium exchanger 6		CALJA		584
+42
Q6J4K2-2	SLC8B1 isoform 12		PANTR		528	UniRef90_Q6J4K2-2
Uncharacterized protein		PANPA		528
Solute carrier family 8 member B1		GORGO		528
Solute carrier family 8 member B1		PANTR		528
UPI0008F4D4C6		GORGO		545

Protein	Similar proteins		Species	Score	Length	Source
Q6J4K2	Mitochondrial sodium/calcium exchanger protein		RAT		585	UniRef50_Q6J4K2
Mitochondrial sodium/calcium exchanger protein		MOUSE		585
Mitochondrial sodium/calcium exchanger protein (Fragment)		HUMAN		131
Uncharacterized protein		MANLE		593
Uncharacterized protein		CERAT		584
+199
Q6J4K2-2	Solute carrier family 8 member B1		PANTR		528	UniRef50_Q6J4K2-2
Uncharacterized protein		PANPA		528
Solute carrier family 8 member B1		GORGO		528
Mitochondrial sodium/calcium exchanger protein		MOUSE		529
mitochondrial sodium/calcium exchanger protein		PHYCD		486
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY601759 mRNA Translation: AAT35807.1 AY601760 mRNA Translation: AAT35808.1 AC010178 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW98050.1 BC098360 mRNA Translation: AAH98360.1 AK025886 mRNA Translation: BAB15271.1 Different initiation.
CCDSⁱ	CCDS31909.1 [Q6J4K2-1] CCDS81744.1 [Q6J4K2-2]
RefSeqⁱ	NP_001317395.1, NM_001330466.1 [Q6J4K2-2] NP_079235.2, NM_024959.3 [Q6J4K2-1] XP_006719670.1, XM_006719607.2 XP_011537051.1, XM_011538749.2 XP_011537054.1, XM_011538752.2
UniGeneⁱ	Hs.286194

3D structure databases

ProteinModelPortalⁱ	Q6J4K2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123078, 2 interactors
IntActⁱ	Q6J4K2, 1 interactor
STRINGⁱ	9606.ENSP00000202831

Chemistry databases

BindingDBⁱ	Q6J4K2
ChEMBLⁱ	CHEMBL3763001

Protein family/group databases

TCDBⁱ	2.A.19.4.4 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.4.4 the ca(2+):cation antiporter (caca) family

PTM databases

iPTMnetⁱ	Q6J4K2
PhosphoSitePlusⁱ	Q6J4K2

Polymorphism and mutation databases

BioMutaⁱ	SLC24A6
DMDMⁱ	85681048

Proteomic databases

MaxQBⁱ	Q6J4K2
PaxDbⁱ	Q6J4K2
PeptideAtlasⁱ	Q6J4K2
PRIDEⁱ	Q6J4K2
ProteomicsDBⁱ	66508 66509 [Q6J4K2-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000202831; ENSP00000202831; ENSG00000089060 [Q6J4K2-1] ENST00000546737; ENSP00000450081; ENSG00000089060 [Q6J4K2-2] ENST00000552014; ENSP00000447091; ENSG00000089060 [Q6J4K2-1]
GeneIDⁱ	80024
KEGGⁱ	hsa:80024
UCSCⁱ	uc001tvc.4 human [Q6J4K2-1]

Organism-specific databases

CTDⁱ	80024
DisGeNETⁱ	80024
EuPathDBⁱ	HostDB:ENSG00000089060.11
GeneCardsⁱ	SLC8B1
H-InvDBⁱ	HIX0171623
HGNCⁱ	HGNC:26175 SLC8B1
HPAⁱ	HPA040668
MIMⁱ	609841 gene
neXtProtⁱ	NX_Q6J4K2
OpenTargetsⁱ	ENSG00000089060
PharmGKBⁱ	PA134954965
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2399 Eukaryota COG0530 LUCA
GeneTreeⁱ	ENSGT00760000119209
HOGENOMⁱ	HOG000113743
HOVERGENⁱ	HBG082009
InParanoidⁱ	Q6J4K2
KOⁱ	K13754
OMAⁱ	AHISPQF
OrthoDBⁱ	EOG091G05GE
PhylomeDBⁱ	Q6J4K2
TreeFamⁱ	TF323444

Enzyme and pathway databases

Reactomeⁱ	R-HSA-425561 Sodium/Calcium exchangers R-HSA-8949215 Mitochondrial calcium ion transport

Reactomeⁱ

R-HSA-425561 Sodium/Calcium exchangers
R-HSA-8949215 Mitochondrial calcium ion transport

Miscellaneous databases

ChiTaRSⁱ	SLC8B1 human
GenomeRNAiⁱ	80024
Protein Ontology More...PROⁱ	PR:Q6J4K2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089060 Expressed in 185 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_SLC24A6
ExpressionAtlasⁱ	Q6J4K2 baseline and differential
Genevisibleⁱ	Q6J4K2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004837 NaCa_Exmemb
Pfamⁱ	View protein in Pfam PF01699 Na_Ca_ex, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NCLX_HUMAN
Accessionⁱ	Q6J4K2Primary (citable) accession number: Q6J4K2 Secondary accession number(s): A6NP50 , Q4KMS9, Q6J4K1, Q9H6I8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	January 10, 2006
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Supporting data

UniProtKB - Q6J4K2 (NCLX_HUMAN)

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Mitochondrial sodium/calcium exchanger protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ