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Entry version 106 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Protein FAM166A

Gene

FAM166A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM166A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM166A
ORF Names:HSD46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188163.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33818 FAM166A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6J272

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188163

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387021

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6J272 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM166A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74709550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259001 – 317Protein FAM166AAdd BLAST317

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6J272

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6J272

PeptideAtlas

More...
PeptideAtlasi
Q6J272

PRoteomics IDEntifications database

More...
PRIDEi
Q6J272

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66505 [Q6J272-1]
66506 [Q6J272-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6J272

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6J272

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188163 Expressed in right testis and 82 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6J272 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188163 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
135153, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6J272, 5 interactors

Molecular INTeraction database

More...
MINTi
Q6J272

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6J272 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6J272

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0605 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IED4 Eukaryota
ENOG410YQTM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111343

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076252_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6J272

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAGFIPR

Database of Orthologous Groups

More...
OrthoDBi
851402at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6J272

TreeFam database of animal gene trees

More...
TreeFami
TF336316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018902 FAM166/UPF0605

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10629 DUF2475, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6J272-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTQKHDLF TPEPHYVPGY AGFFPQLRYQ VGNTYGRTTG QLLTDPSVQK
60 70 80 90 100
SPCSVLSPMS KPKFIEDFSQ SKPPRVPCQD LTEPYIPHYT SLKPSKNFEI
110 120 130 140 150
LGQLPPLEVD AQEPPGVENI PRQILLPAGF TPDTPHPPCP PGRKGDSRDL
160 170 180 190 200
GHPVYGEEAW KSATPVCEAP RQHQLYHCQR DEYPPPARRQ QETLDVGSFQ
210 220 230 240 250
RLPQLDHPNL IQRKAISGYA GFIPRFTWVM GLNYRDGVMQ AMDEFDKSQF
260 270 280 290 300
LFRNPHCDLG EKLPGTHWPS NHIYSSQGLI PFYMGFIPAM QDNYALTFGN
310
STRRAYWKEW AKRNHTL
Length:317
Mass (Da):36,165
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i287D6C5BFCADBD0B
GO
Isoform 2 (identifier: Q6J272-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-287: GYAGFIPRFT...GLIPFYMGFI → EQASGLGGPP...GTKGSLAWLP
     288-317: Missing.

Show »
Length:271
Mass (Da):30,089
Checksum:i9AA612C0224DEE80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBW9C9JBW9_HUMAN
Protein FAM166A
FAM166A
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032470218 – 287GYAGF…YMGFI → EQASGLGGPPLPPSCFQEPS FSQDEAVPCLPVPIWPHQTV ANVQGTKGSLAWLP in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_032471288 – 317Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097419 mRNA Translation: BAC05044.1
AY604177 mRNA Translation: AAT36740.1
BX255925 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88371.1
CH471090 Genomic DNA Translation: EAW88372.1
BC132916 mRNA Translation: AAI32917.1
BC132918 mRNA Translation: AAI32919.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35186.1 [Q6J272-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001001710.1, NM_001001710.2 [Q6J272-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344774; ENSP00000344729; ENSG00000188163 [Q6J272-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
401565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:401565

UCSC genome browser

More...
UCSCi
uc004cmi.3 human [Q6J272-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097419 mRNA Translation: BAC05044.1
AY604177 mRNA Translation: AAT36740.1
BX255925 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88371.1
CH471090 Genomic DNA Translation: EAW88372.1
BC132916 mRNA Translation: AAI32917.1
BC132918 mRNA Translation: AAI32919.1
CCDSiCCDS35186.1 [Q6J272-1]
RefSeqiNP_001001710.1, NM_001001710.2 [Q6J272-1]

3D structure databases

SMRiQ6J272
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi135153, 1 interactor
IntActiQ6J272, 5 interactors
MINTiQ6J272
STRINGi9606.ENSP00000344729

PTM databases

iPTMnetiQ6J272
PhosphoSitePlusiQ6J272

Polymorphism and mutation databases

BioMutaiFAM166A
DMDMi74709550

Proteomic databases

MassIVEiQ6J272
PaxDbiQ6J272
PeptideAtlasiQ6J272
PRIDEiQ6J272
ProteomicsDBi66505 [Q6J272-1]
66506 [Q6J272-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18988 59 antibodies

The DNASU plasmid repository

More...
DNASUi
401565

Genome annotation databases

EnsembliENST00000344774; ENSP00000344729; ENSG00000188163 [Q6J272-1]
GeneIDi401565
KEGGihsa:401565
UCSCiuc004cmi.3 human [Q6J272-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
401565
EuPathDBiHostDB:ENSG00000188163.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM166A
HGNCiHGNC:33818 FAM166A
HPAiENSG00000188163 Tissue enriched (testis)
neXtProtiNX_Q6J272
OpenTargetsiENSG00000188163
PharmGKBiPA162387021

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IED4 Eukaryota
ENOG410YQTM LUCA
GeneTreeiENSGT00730000111343
HOGENOMiCLU_076252_0_0_1
InParanoidiQ6J272
OMAiYAGFIPR
OrthoDBi851402at2759
PhylomeDBiQ6J272
TreeFamiTF336316

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
401565 11 hits in 784 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM166A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
401565
PharosiQ6J272 Tdark

Protein Ontology

More...
PROi
PR:Q6J272
RNActiQ6J272 protein

Gene expression databases

BgeeiENSG00000188163 Expressed in right testis and 82 other tissues
ExpressionAtlasiQ6J272 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR018902 FAM166/UPF0605
PfamiView protein in Pfam
PF10629 DUF2475, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF166A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6J272
Secondary accession number(s): A6NND9, Q8N830
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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