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UniProtKB - Q6J1H4 (UTF1_MOUSE)
Protein
Undifferentiated embryonic cell transcription factor 1
Gene
Utf1
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a transcriptional coactivator of ATF2.
1 PublicationGO - Molecular functioni
- HMG box domain binding Source: UniProtKB
- TBP-class protein binding Source: MGI
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Undifferentiated embryonic cell transcription factor 1 |
Gene namesi | Name:Utf1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1276125, Utf1 |
VEuPathDBi | HostDB:ENSMUSG00000047751 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274552 | 1 – 339 | Undifferentiated embryonic cell transcription factor 1Add BLAST | 339 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 48 | PhosphoserineCombined sources | 1 | |
Modified residuei | 54 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6J1H4 |
PeptideAtlasi | Q6J1H4 |
PRIDEi | Q6J1H4 |
ProteomicsDBi | 297950 [Q6J1H4-1] |
PTM databases
iPTMneti | Q6J1H4 |
PhosphoSitePlusi | Q6J1H4 |
Expressioni
Tissue specificityi
Expressed mainly in pluripotent cells with expression rapidly down-regulated upon cell differentiation.1 Publication
Developmental stagei
First detected in the embryo at the blastocyst stage. Little or no expression detected in adult tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000047751, Expressed in epiblast (generic) and 63 other tissues |
Genevisiblei | Q6J1H4, MM |
Interactioni
Subunit structurei
Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
1 PublicationGO - Molecular functioni
- HMG box domain binding Source: UniProtKB
- TBP-class protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204468, 7 interactors |
STRINGi | 10090.ENSMUSP00000128848 |
Miscellaneous databases
RNActi | Q6J1H4, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 144 – 270 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 279 – 310 | Leucine-zipperAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 201 – 247 | Polar residuesSequence analysisAdd BLAST | 47 |
Domaini
The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters.1 Publication
Phylogenomic databases
eggNOGi | KOG4282, Eukaryota |
GeneTreei | ENSGT00390000014419 |
HOGENOMi | CLU_074827_0_0_1 |
InParanoidi | Q6J1H4 |
OMAi | CRRRYKF |
PhylomeDBi | Q6J1H4 |
TreeFami | TF337319 |
Family and domain databases
InterProi | View protein in InterPro IPR044822, Myb_DNA-bind_4 |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketIsoform 11 Publication (identifier: Q6J1H4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLRPRRLPA FSPPSPASPD AELRSAGDVP VTTSDAFATS GGMAEPGSPK
60 70 80 90 100
APVSPDSAQR TPWSARETEL LLGTLLQPAM WRSLLLDRRQ TLPTYRRVSA
110 120 130 140 150
ALARQQVRRT PAQCRRRYKF LKDKLRDSQG QPSGPFDNQI RQLMGLLGDD
160 170 180 190 200
GPPRVRRRST GPGRPQRRGR SSLSALAPAP APVEQEAELP LAAENDEPAP
210 220 230 240 250
ALRFSSSTTK SAGAHRITSS PPLTSTDTLP PEPGHTFESS PTPTPDHDVE
260 270 280 290 300
TPNEPPGLSQ GRASSPQVAP QSLNTALLQT LTHLGDISTV LGPLRDQLST
310 320 330
LNQHVEHLRG SFDQTVSLAV GFILGSAASE RGILGDLRQ
Sequence cautioni
The sequence AAT38948 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052292 | 1 – 42 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31647 mRNA Translation: BAA25403.1 AB017360 Genomic DNA Translation: BAA82667.1 AY606111 mRNA Translation: AAT38948.1 Different initiation. |
CCDSi | CCDS21958.1 [Q6J1H4-1] |
PIRi | JC7712 |
RefSeqi | NP_033508.1, NM_009482.2 [Q6J1H4-1] |
Genome annotation databases
Ensembli | ENSMUST00000168457; ENSMUSP00000128848; ENSMUSG00000047751 [Q6J1H4-1] |
GeneIDi | 22286 |
KEGGi | mmu:22286 |
UCSCi | uc009kgf.1, mouse [Q6J1H4-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31647 mRNA Translation: BAA25403.1 AB017360 Genomic DNA Translation: BAA82667.1 AY606111 mRNA Translation: AAT38948.1 Different initiation. |
CCDSi | CCDS21958.1 [Q6J1H4-1] |
PIRi | JC7712 |
RefSeqi | NP_033508.1, NM_009482.2 [Q6J1H4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204468, 7 interactors |
STRINGi | 10090.ENSMUSP00000128848 |
PTM databases
iPTMneti | Q6J1H4 |
PhosphoSitePlusi | Q6J1H4 |
Proteomic databases
PaxDbi | Q6J1H4 |
PeptideAtlasi | Q6J1H4 |
PRIDEi | Q6J1H4 |
ProteomicsDBi | 297950 [Q6J1H4-1] |
Protocols and materials databases
DNASUi | 22286 |
Genome annotation databases
Ensembli | ENSMUST00000168457; ENSMUSP00000128848; ENSMUSG00000047751 [Q6J1H4-1] |
GeneIDi | 22286 |
KEGGi | mmu:22286 |
UCSCi | uc009kgf.1, mouse [Q6J1H4-1] |
Organism-specific databases
CTDi | 8433 |
MGIi | MGI:1276125, Utf1 |
VEuPathDBi | HostDB:ENSMUSG00000047751 |
Phylogenomic databases
eggNOGi | KOG4282, Eukaryota |
GeneTreei | ENSGT00390000014419 |
HOGENOMi | CLU_074827_0_0_1 |
InParanoidi | Q6J1H4 |
OMAi | CRRRYKF |
PhylomeDBi | Q6J1H4 |
TreeFami | TF337319 |
Miscellaneous databases
BioGRID-ORCSi | 22286, 3 hits in 66 CRISPR screens |
PROi | PR:Q6J1H4 |
RNActi | Q6J1H4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047751, Expressed in epiblast (generic) and 63 other tissues |
Genevisiblei | Q6J1H4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR044822, Myb_DNA-bind_4 |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UTF1_MOUSE | |
Accessioni | Q6J1H4Primary (citable) accession number: Q6J1H4 Secondary accession number(s): O70530 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 100 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot