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Entry version 99 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Receptor for egg jelly 4

Gene

REJ4

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.5.1.5, the polycystin cation channel (pcc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Receptor for egg jelly 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REJ4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaCamarodontaEchinideaStrongylocentrotidaeStrongylocentrotus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_490553_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752, PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.180.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037060, Catalase_core_sf
IPR000203, GPS
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825, GPS, 1 hit
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00089, PKD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 3 hits
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6IVD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVLTWKFVF LVITSHLAIT GSGVRANENL FTVSIPSLLE VNQTFEIAFW
60 70 80 90 100
TDFPFFFECY WDFNDNIIYI ANATDLQEPL IHKYTQPAAY NILTNCCMAG
110 120 130 140 150
QLEAHFSEVL VYSEIYYEIC SYRSVNLTYN YDIYILGESD LLIFNHHEFP
160 170 180 190 200
DPLYYYMELD GYPVFDEVFS HGALQNDDLY AVLLDTLPFP MELQNIIGLG
210 220 230 240 250
PHNVSVTVYS EINNTAVYCE SQIKFVELIT GMVFYISEYF VQTNNPFIGS
260 270 280 290 300
LAAESGWPAL IEWSAYNEDT FELEFYFDSY RQARSPDEVD EVWLFISKPG
310 320 330 340 350
NYTLRATMYH EINEASEYTT IIVENPITTL DISLNAPLHY PLEDTLQMFV
360 370 380 390 400
NYTSDGIPTD IXGDIDYGDG TIEWWEPIPS EPDYRNLTFN HLYAVPDLYT
410 420 430 440 450
VQLFLYNYVS SVQYEWYVAV LEDIEDLAID SFSGEDGTWT AILPIEFPVI
460 470 480 490 500
LTAQPLKGTI ELCEWNVGGY LFNSTNPTIM YEFNAEGVYD IEVRATNAFS
510 520 530 540 550
SGRASTNVTV LESITGIYLI NDGPVMQADA VTFVLFSYQL GSNSLFALDY
560 570 580 590 600
GDGTSETLQE PRIQENVTMY IPSDLDLPFN PREYFSVRVE HTYVSAGSYT
610 620 630 640 650
ATASASDAVS IRHAMSDAFV QASPCFLPNM HILDGESSYS XAKQYHRQKR
660 670 680 690 700
FQFAAEVNID CVMAASTHYE WLVFKLNDVF TVPVDENLYQ LPASIRTDLT
710 720 730 740 750
TLYVPAFTLE YGTYVFRLHV TINLRDGSVG VNKNDQTYIR VVESPLYAVI
760 770 780 790 800
NGGSSRAIGW YRDIYMDGSL SKDPDVDGNQ DGLLFSWFCR RSNETFPSND
810 820 830 840 850
DLLLLVNQPS GDDGCLHEGF LMQSGNQTTM TIAGQTLEGN QTHVFRLVVS
860 870 880 890 900
KQGRGTAHAE QTIPILPGDP PTILIKCMTN CGFSLNPSER FVISANCDDC
910 920 930 940 950
TLQTRPRYFW SLIPAFLNNS KQFLIWNQDT TTSRTNAYLA IRAFTFQGSE
960 970 980 990 1000
EYTLKVLVFS WSGAKTFAEY AFSTNSPPLL GTCSATPDEG VVLETHFTII
1010 1020 1030 1040 1050
CQGFVDEDEP LSYEVRALTG SEKKTGISSF HDSSTSGTLI YFGVDPHIPP
1060 1070 1080 1090 1100
TFLPVGIASH CDHQVDIIIT VSDTYGASIK TSTAVKVREA EVDTSQPDKT
1110 1120 1130 1140 1150
VTDTVLEFSS GEENPLSKLL ESGDTQSATQ LVFTLTSLLN ADAESDFDQA
1160 1170 1180 1190 1200
EAATEEEQEE ESEFMEEKKT KRAEARESII ANIGHIEVRD METLQQTSAV
1210 1220 1230 1240 1250
IAQVTQEKDE ISATAQKSAA KSYQEMCHFL KEESGSGHTG GDTVEETASF
1260 1270 1280 1290 1300
IMVGLSNIME AAFSTLTSVV NETTPVTSQD DDAEKAISDT RNVSMATLQA
1310 1320 1330 1340 1350
LEELQTAVLQ NKVPGEESTV IRTEAVSLIL QRQERWEVAS KVSDSKAGAT
1360 1370 1380 1390 1400
SFQLPSNVLD GGTESSFDDI VDSHIHEYNH NPFAWASMGG EDDITSQVSS
1410 1420 1430 1440 1450
LELELSDGNQ HTKLTPVNLP KDIDIFIDNE DTKVQQLQAA KESQSGEINY
1460 1470 1480 1490 1500
YFNVISQMAY VVVEVVVYNH SLYEPFPELS LFLTRNETGT NSSAGVDATH
1510 1520 1530 1540 1550
ILNTSFPAGA DPPVSALNDT HNMTGNPYLW IIPFSEIGVN GDHGLVLSGW
1560 1570 1580 1590 1600
GMVNKSDIAL YAYGAQCVYW NTEEEMWDTT GCKVGPLTSR ILAHCQCNHL
1610 1620 1630 1640 1650
SHFAAGFVVL PNTVHFIKDA SLFAKILENP ITAMTVGSVF ALYVLVAVWA
1660 1670 1680 1690 1700
NRHDRRAEEQ ARVIFLGDNN PEAQYNYHVT IFTGLRRVAG TTAVATITLY
1710 1720 1730 1740 1750
GAAGSSEPHV LTTEGKRKIL QRGGVDSFVL STHGSLEELT AVRVWHDNSG
1760 1770 1780 1790 1800
KQPEWHLNRI LVHDLQTKQL WYFLCHTWLA VDLGECTVDK TFPVATTEDL
1810 1820 1830 1840 1850
QQFQHLFITG LLRDMKDHHL WVSIFTRPPN SNFTRLQRIT CCFTLLMMSM
1860 1870 1880 1890 1900
LASIMFFGIT PEDVDVGDSK GPEMSQEIGM GTIRVTWFDI LVGIESGLLV
1910 1920 1930 1940 1950
LPGNLLILEI FRNVRSRHPS KGDKSVEIVA ESEDDKSGTT KTTSEQSTKS
1960 1970 1980 1990 2000
IATASLKASD GENVPHHAGD GSQNHSEQIP SEAQSPETIT QEKMNNEHDI
2010 2020 2030 2040 2050
ESQIQPVAQS VWIDSASNEC SKSADVSVRS IHVSTTEEIP PCCCLRPCYK
2060 2070 2080 2090 2100
GSEHDDVVSG GGDDRLHRTA SSSVLSSSDS QPESLSPEAT ELQNRPPFFM
2110 2120 2130 2140 2150
RHEDYLHHHI NTMHEEIYHA PEGYFKSEED RKKALRKLEE TLKVHGWYQH
2160 2170 2180 2190 2200
LQEEEEGHAA TEDQDKSGCC QGDSQGCLPW WFVYIGWFFV VVTNLVCGYL
2210 2220 2230 2240 2250
VILYGLTYGL QTSMDWLVSM MVSLFQSIFV LQPGKVILVA AFSAVIWKKH
2260 2270 2280 2290 2300
EXDDVGVDLF TDPATGIFMT PANAKGRGKR HTIARYYQPP TIESVNQVRE
2310 2320 2330 2340 2350
RREAEAKMCK MLKELLGQIL LVVLALEVAH FQRDPNNYLF HQTVANTFTA
2360 2370 2380 2390 2400
GFEDVSSIND VYGYLEESFV PELYGENRGF LGDESTYRVG RARLRQVRII
2410 2420 2430 2440 2450
PDACTPPKPT QHIVNCTGIL RSQSHTNQQT YNKSWSELLE DDTESKAITD
2460 2470 2480 2490 2500
SYGPWKFTPS RSSHGSYHMG TVTLYTQGGY IQVLSSTARS TLRVLQELED
2510 2520 2530 2540 2550
RKWLDELTRA LYIEWTVFSA DAGLMCVCTV LFEATTMGNL VSTGEFHAFK
2560 2570 2580 2590 2600
IFSLETVVDK INLALQSVYL LVILGLIHLE VKKMRRKKRA YFQFWNILNI
2610 2620 2630 2640 2650
LTIILSILSA VFYSLWATSL HKAMKDYTQN PSKFISFFYP VIMDQTFMAV
2660 2670 2680 2690 2700
TGFLVFINTL RCAKILRFNS SIQTIHHTFS NITSEFFIFT LMVLIFLFAF
2710 2720 2730 2740 2750
ALLFCVTFGS DVMDFKDVAF SFQTIFLFLE GGYEEFMDVS EIYATLGPLY
2760 2770 2780 2790 2800
FIFMTIALFF LLFNFYILLI LYAFRDARHI LPNEDHKDVL SAIVDWLFSV
2810 2820
CSIRKVSRKD ETMKSAPVFK HYRGELTLE
Length:2,829
Mass (Da):317,853
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBECB1EB142850AEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei2829Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY620398 mRNA Translation: AAT40426.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620398 mRNA Translation: AAT40426.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein family/group databases

TCDBi1.A.5.1.5, the polycystin cation channel (pcc) family

Phylogenomic databases

eggNOGiKOG3599, Eukaryota
HOGENOMiCLU_490553_0_0_1

Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR037060, Catalase_core_sf
IPR000203, GPS
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom
PfamiView protein in Pfam
PF01825, GPS, 1 hit
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00089, PKD, 2 hits
SUPFAMiSSF49299, SSF49299, 3 hits
SSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6IVD6_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IVD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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