UniProtKB - Q6IT96 (Q6IT96_HUMAN)
Protein
Histone deacetylase
Gene
HDAC1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.1.98UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | SubstrateUniRule annotation | 1 | |
Active sitei | 141 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 149 | Substrate; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 176 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 178 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 264 | Divalent metal cationUniRule annotation | 1 | |
Binding sitei | 303 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- E-box binding Source: Ensembl
- Krueppel-associated box domain binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
- NF-kappaB binding Source: UniProtKB
- promoter-specific chromatin binding Source: Ensembl
- RNA polymerase II repressing transcription factor binding Source: Ensembl
- transcription corepressor activity Source: Ensembl
GO - Biological processi
- circadian regulation of gene expression Source: Ensembl
- embryonic digit morphogenesis Source: Ensembl
- endoderm development Source: Ensembl
- epidermal cell differentiation Source: Ensembl
- eyelid development in camera-type eye Source: Ensembl
- fungiform papilla formation Source: Ensembl
- hair follicle placode formation Source: Ensembl
- hippocampus development Source: Ensembl
- histone H4 deacetylation Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron differentiation Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
Keywordsi
Molecular function | Chromatin regulatorUniRule annotationARBA annotation, HydrolaseUniRule annotationARBA annotation, RepressorARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone deacetylaseUniRule annotationARBA annotation (EC:3.5.1.98UniRule annotationARBA annotation) |
Gene namesi | Name:HDAC1Imported ORF Names:hCG_41610Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000116478.11 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleoplasm Source: HPA
- NuRD complex Source: Ensembl
Other locations
- heterochromatin Source: Ensembl
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000116478, Expressed in colonic mucosa and 247 other tissues |
ExpressionAtlasi | Q6IT96, baseline and differential |
Interactioni
Binary interactionsi
Q6IT96
With | #Exp. | IntAct |
---|---|---|
E4F1 [Q66K89] | 2 | EBI-6979193,EBI-1227043 |
GO - Molecular functioni
- Krueppel-associated box domain binding Source: Ensembl
- NF-kappaB binding Source: UniProtKB
- RNA polymerase II repressing transcription factor binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q6IT96, 5 interactors |
Chemistry databases
BindingDBi | Q6IT96 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 317 | Hist_deacetylInterPro annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 390 – 482 | DisorderedSequence analysisAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 400 – 482 | PolyampholyteSequence analysisAdd BLAST | 83 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_007727_7_4_1 |
OMAi | VSIRAHD |
OrthoDBi | 732770at2759 |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6IT96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK
60 70 80 90 100
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC
110 120 130 140 150
PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF
160 170 180 190 200
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK
210 220 230 240 250
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME
260 270 280 290 300
MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
310 320 330 340 350
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM
360 370 380 390 400
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD
410 420 430 440 450
PDKRISICSS DKRIACEEEF SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE
460 470 480
KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY627042 mRNA Translation: AAT44863.1 AB451430 mRNA Translation: BAG70244.1 CR541717 mRNA Translation: CAG46518.1 CH471059 Genomic DNA Translation: EAX07540.1 CH471059 Genomic DNA Translation: EAX07541.1 |
RefSeqi | NP_004955.2, NM_004964.2 |
Genome annotation databases
GeneIDi | 3065 |
KEGGi | hsa:3065 |
UCSCi | uc001bvb.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY627042 mRNA Translation: AAT44863.1 AB451430 mRNA Translation: BAG70244.1 CR541717 mRNA Translation: CAG46518.1 CH471059 Genomic DNA Translation: EAX07540.1 CH471059 Genomic DNA Translation: EAX07541.1 |
RefSeqi | NP_004955.2, NM_004964.2 |
3D structure databases
SMRi | Q6IT96 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6IT96, 5 interactors |
Chemistry databases
BindingDBi | Q6IT96 |
Proteomic databases
MaxQBi | Q6IT96 |
PRIDEi | Q6IT96 |
Protocols and materials databases
Antibodypediai | 3760, 1526 antibodies |
DNASUi | 3065 |
Genome annotation databases
GeneIDi | 3065 |
KEGGi | hsa:3065 |
UCSCi | uc001bvb.2, human |
Organism-specific databases
CTDi | 3065 |
PharmGKBi | PA29226 |
VEuPathDBi | HostDB:ENSG00000116478.11 |
Phylogenomic databases
HOGENOMi | CLU_007727_7_4_1 |
OMAi | VSIRAHD |
OrthoDBi | 732770at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3065, 28 hits in 882 CRISPR screens |
ChiTaRSi | HDAC1, human |
GenomeRNAii | 3065 |
Gene expression databases
Bgeei | ENSG00000116478, Expressed in colonic mucosa and 247 other tissues |
ExpressionAtlasi | Q6IT96, baseline and differential |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6IT96_HUMAN | |
Accessioni | Q6IT96Primary (citable) accession number: Q6IT96 Secondary accession number(s): D3DPP9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |