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Protein

Leukocyte-associated immunoglobulin-like receptor 2

Gene

LAIR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte-associated immunoglobulin-like receptor 2
Short name:
LAIR-2
Alternative name(s):
CD_antigen: CD306
Gene namesi
Name:LAIR2
Synonyms:CD306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167618.9
HGNCiHGNC:6478 LAIR2
MIMi602993 gene
neXtProtiNX_Q6ISS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3904
OpenTargetsiENSG00000167618
PharmGKBiPA30267

Polymorphism and mutation databases

BioMutaiLAIR2
DMDMi74736630

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025068522 – 152Leukocyte-associated immunoglobulin-like receptor 2Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ6ISS4
PaxDbiQ6ISS4
PeptideAtlasiQ6ISS4
PRIDEiQ6ISS4
ProteomicsDBi66494
66495 [Q6ISS4-2]

PTM databases

iPTMnetiQ6ISS4
PhosphoSitePlusiQ6ISS4

Expressioni

Gene expression databases

BgeeiENSG00000167618 Expressed in 109 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LAIR2
ExpressionAtlasiQ6ISS4 baseline and differential
GenevisibleiQ6ISS4 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110099, 34 interactors
IntActiQ6ISS4, 5 interactors
STRINGi9606.ENSP00000301202

Structurei

3D structure databases

ProteinModelPortaliQ6ISS4
SMRiQ6ISS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 117Ig-like C2-typeAdd BLAST89

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J37Q Eukaryota
ENOG41119RI LUCA
GeneTreeiENSGT00720000108843
HOGENOMiHOG000234395
InParanoidiQ6ISS4
KOiK06725
OMAiTFQCRGP
OrthoDBiEOG091G0RAQ
PhylomeDBiQ6ISS4
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6ISS4-1) [UniParc]FASTAAdd to basket
Also known as: LAIR-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR
60 70 80 90 100
GPVGVQTFRL EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR
110 120 130 140 150
CLYYKPPGWS EHSDFLELLV KESSGGPDSP DTEPGSSAGT VPGTEASGFD

AP
Length:152
Mass (Da):16,280
Last modified:July 5, 2004 - v1
Checksum:i8097688A9DB42EC8
GO
Isoform 2 (identifier: Q6ISS4-2) [UniParc]FASTAAdd to basket
Also known as: LAIR-2b

The sequence of this isoform differs from the canonical sequence as follows:
     122-138: Missing.

Show »
Length:135
Mass (Da):14,722
Checksum:i5053FD160CF31CC7
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPH6A0A0G2JPH6_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
208Annotation score:
A0A0G2JMB1A0A0G2JMB1_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
175Annotation score:
C9JFQ0C9JFQ0_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
89Annotation score:
A0A087X1V4A0A087X1V4_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
77Annotation score:
A0A0G2JN10A0A0G2JN10_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
115Annotation score:
A0A0G2JLQ0A0A0G2JLQ0_HUMAN
Leukocyte-associated immunoglobulin...
LAIR2
100Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04988278G → S. Corresponds to variant dbSNP:rs36121405Ensembl.1
Natural variantiVAR_04988387H → R. Corresponds to variant dbSNP:rs34423078Ensembl.1
Natural variantiVAR_049884115F → Y. Corresponds to variant dbSNP:rs34429135Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020720122 – 138Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013250 mRNA Translation: AAB69325.1
AA133246 mRNA No translation available.
BC069366 mRNA Translation: AAH69366.1
CCDSiCCDS12897.1 [Q6ISS4-1]
CCDS12898.1 [Q6ISS4-2]
RefSeqiNP_002279.2, NM_002288.5 [Q6ISS4-1]
NP_067154.1, NM_021270.4 [Q6ISS4-2]
UniGeneiHs.43803

Genome annotation databases

EnsembliENST00000301202; ENSP00000301202; ENSG00000167618 [Q6ISS4-1]
ENST00000351841; ENSP00000301203; ENSG00000167618 [Q6ISS4-2]
ENST00000612901; ENSP00000478193; ENSG00000274084 [Q6ISS4-1]
ENST00000620256; ENSP00000477747; ENSG00000274084 [Q6ISS4-2]
ENST00000621280; ENSP00000480904; ENSG00000277335 [Q6ISS4-2]
ENST00000622556; ENSP00000477535; ENSG00000277335 [Q6ISS4-1]
GeneIDi3904
KEGGihsa:3904
UCSCiuc002qgc.4 human [Q6ISS4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013250 mRNA Translation: AAB69325.1
AA133246 mRNA No translation available.
BC069366 mRNA Translation: AAH69366.1
CCDSiCCDS12897.1 [Q6ISS4-1]
CCDS12898.1 [Q6ISS4-2]
RefSeqiNP_002279.2, NM_002288.5 [Q6ISS4-1]
NP_067154.1, NM_021270.4 [Q6ISS4-2]
UniGeneiHs.43803

3D structure databases

ProteinModelPortaliQ6ISS4
SMRiQ6ISS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110099, 34 interactors
IntActiQ6ISS4, 5 interactors
STRINGi9606.ENSP00000301202

PTM databases

iPTMnetiQ6ISS4
PhosphoSitePlusiQ6ISS4

Polymorphism and mutation databases

BioMutaiLAIR2
DMDMi74736630

Proteomic databases

MaxQBiQ6ISS4
PaxDbiQ6ISS4
PeptideAtlasiQ6ISS4
PRIDEiQ6ISS4
ProteomicsDBi66494
66495 [Q6ISS4-2]

Protocols and materials databases

DNASUi3904
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301202; ENSP00000301202; ENSG00000167618 [Q6ISS4-1]
ENST00000351841; ENSP00000301203; ENSG00000167618 [Q6ISS4-2]
ENST00000612901; ENSP00000478193; ENSG00000274084 [Q6ISS4-1]
ENST00000620256; ENSP00000477747; ENSG00000274084 [Q6ISS4-2]
ENST00000621280; ENSP00000480904; ENSG00000277335 [Q6ISS4-2]
ENST00000622556; ENSP00000477535; ENSG00000277335 [Q6ISS4-1]
GeneIDi3904
KEGGihsa:3904
UCSCiuc002qgc.4 human [Q6ISS4-1]

Organism-specific databases

CTDi3904
DisGeNETi3904
EuPathDBiHostDB:ENSG00000167618.9
GeneCardsiLAIR2
HGNCiHGNC:6478 LAIR2
MIMi602993 gene
neXtProtiNX_Q6ISS4
OpenTargetsiENSG00000167618
PharmGKBiPA30267
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J37Q Eukaryota
ENOG41119RI LUCA
GeneTreeiENSGT00720000108843
HOGENOMiHOG000234395
InParanoidiQ6ISS4
KOiK06725
OMAiTFQCRGP
OrthoDBiEOG091G0RAQ
PhylomeDBiQ6ISS4
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GeneWikiiLAIR2
GenomeRNAii3904
PROiPR:Q6ISS4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167618 Expressed in 109 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LAIR2
ExpressionAtlasiQ6ISS4 baseline and differential
GenevisibleiQ6ISS4 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAIR2_HUMAN
AccessioniPrimary (citable) accession number: Q6ISS4
Secondary accession number(s): Q6PEZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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