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Protein

Centrosomal protein of 78 kDa

Gene

Cep78

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 78 kDa
Short name:
Cep78
Gene namesi
Name:Cep78
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1924386 Cep78

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919531 – 790Centrosomal protein of 78 kDaAdd BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6IRU7
PaxDbiQ6IRU7
PeptideAtlasiQ6IRU7
PRIDEiQ6IRU7

PTM databases

iPTMnetiQ6IRU7
PhosphoSitePlusiQ6IRU7

Expressioni

Tissue specificityi

Expressed by photoreceptor cells in the retina.1 Publication

Developmental stagei

Expressed at all stages of development with higher expression during embryogenesis.2 Publications

Gene expression databases

BgeeiENSMUSG00000041491 Expressed in 193 organ(s), highest expression level in oocyte
CleanExiMM_CEP78
GenevisibleiQ6IRU7 MM

Interactioni

Subunit structurei

Interacts with PLK4. Interacts with FAM161A.By similarity

Protein-protein interaction databases

BioGridi228987, 35 interactors
IntActiQ6IRU7, 35 interactors
STRINGi10090.ENSMUSP00000037596

Structurei

3D structure databases

ProteinModelPortaliQ6IRU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili455 – 510Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the CEP78 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00390000013287
HOGENOMiHOG000015235
HOVERGENiHBG056294
InParanoidiQ6IRU7
KOiK16765
OMAiVDHSVMK
OrthoDBiEOG091G0AYV
PhylomeDBiQ6IRU7
TreeFamiTF328928

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026212 Cep78
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PRINTSiPR02062 CENTROSOME78

Sequencei

Sequence statusi: Complete.

Q6IRU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDSVKLRRD CAADFFSHYE YLCALQDSVP LPAVRACLRD GVLDFNADRL
60 70 80 90 100
RAVDWAPLLS TLRVNRDLPL VAIKSSFQPW LGETVLRSGG ADTHRICRNR
110 120 130 140 150
VPAVRSKDIS FQLCKALRGC LSVSGVLRNL ELNGLILRER DLTSLTKGLS
160 170 180 190 200
KSTSLVHLSL ANCPIGDGGL EIICQGIKNS VTLKTVNFTG CNLTWQGACH
210 220 230 240 250
MAKILKYQTM RRHEETWAES LRYRRPDLDC MAGLRRITLN CNTLIGDQGA
260 270 280 290 300
SAFADSLSED LWLRALDLQQ CGLTSEGAKA LLEALETNRT LVVLDIRKNP
310 320 330 340 350
LIDHSMMKAV IKKVLQNGRS ADSEYQWVTS PSSKEPSKTA KQRKKTIVLG
360 370 380 390 400
SSRKGKATIR IGLATKKPSS NGRKQGLGKD CYAPNPLPPG ASGFLPWRTA
410 420 430 440 450
ERAKRSRSSS LIKTRDLSNH LKKSDFPVTV TVESPSSSET DETEDSSESV
460 470 480 490 500
QEAPQKTSIK EETLQEKLEE CLRQLKEERV IRLKADKRVS ELEHENAQLR
510 520 530 540 550
NINFSLSEAL HAQSLTNMIL DDEGVLGSIE NSFQKFHAFL DLLKDAGLGQ
560 570 580 590 600
LATMAGIDQS DFHLLGRPQM NSTVNTPIQE QKALEDETLH PKQTATGQMQ
610 620 630 640 650
DIRFQKITSD ALIPLPLNTV QDPASAQEAV GASRDHLGVV GLEQQEGSAA
660 670 680 690 700
GFIAKTGSPL AGGIPGGRSQ REEEVLSKHS RSSSEKGSTA SEPSRRPSAE
710 720 730 740 750
RHPRKDLLSD ADPPGNSESK GPGDRRSLLN EPIKSESLKK CISIKKENRI
760 770 780 790
VTVSSKTIKS KPNLLEHSES DTLGSDFELQ ERVHSSAHLT
Length:790
Mass (Da):86,890
Last modified:July 5, 2004 - v1
Checksum:i3A6A098B010B6869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070400 mRNA Translation: AAH70400.1
CCDSiCCDS29682.1
RefSeqiNP_932136.2, NM_198019.2
UniGeneiMm.105652

Genome annotation databases

EnsembliENSMUST00000047704; ENSMUSP00000037596; ENSMUSG00000041491
GeneIDi208518
KEGGimmu:208518
UCSCiuc008gwq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070400 mRNA Translation: AAH70400.1
CCDSiCCDS29682.1
RefSeqiNP_932136.2, NM_198019.2
UniGeneiMm.105652

3D structure databases

ProteinModelPortaliQ6IRU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228987, 35 interactors
IntActiQ6IRU7, 35 interactors
STRINGi10090.ENSMUSP00000037596

PTM databases

iPTMnetiQ6IRU7
PhosphoSitePlusiQ6IRU7

Proteomic databases

MaxQBiQ6IRU7
PaxDbiQ6IRU7
PeptideAtlasiQ6IRU7
PRIDEiQ6IRU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047704; ENSMUSP00000037596; ENSMUSG00000041491
GeneIDi208518
KEGGimmu:208518
UCSCiuc008gwq.1 mouse

Organism-specific databases

CTDi84131
MGIiMGI:1924386 Cep78

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00390000013287
HOGENOMiHOG000015235
HOVERGENiHBG056294
InParanoidiQ6IRU7
KOiK16765
OMAiVDHSVMK
OrthoDBiEOG091G0AYV
PhylomeDBiQ6IRU7
TreeFamiTF328928

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q6IRU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041491 Expressed in 193 organ(s), highest expression level in oocyte
CleanExiMM_CEP78
GenevisibleiQ6IRU7 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026212 Cep78
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PRINTSiPR02062 CENTROSOME78
ProtoNetiSearch...

Entry informationi

Entry nameiCEP78_MOUSE
AccessioniPrimary (citable) accession number: Q6IRU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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