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Protein

Clathrin light chain B

Gene

Cltb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

  • clathrin heavy chain binding Source: GO_Central
  • peptide binding Source: MGI
  • structural molecule activity Source: InterPro

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-5099900 WNT5A-dependent internalization of FZD4
R-MMU-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
Gene namesi
Name:Cltb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1921575 Cltb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057721 – 229Clathrin light chain BAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei187PhosphothreonineBy similarity1
Disulfide bondi199 ↔ 209By similarity
Modified residuei204N6-acetyllysineCombined sources1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PeptideAtlasiQ6IRU5
PRIDEiQ6IRU5

2D gel databases

REPRODUCTION-2DPAGEiQ6IRU5

PTM databases

iPTMnetiQ6IRU5
PhosphoSitePlusiQ6IRU5
SwissPalmiQ6IRU5

Expressioni

Gene expression databases

BgeeiENSMUSG00000047547 Expressed in 279 organ(s), highest expression level in cerebellum
CleanExiMM_CLTB
ExpressionAtlasiQ6IRU5 baseline and differential
GenevisibleiQ6IRU5 MM

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216666, 1 interactor
IntActiQ6IRU5, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6IRU5
SMRiQ6IRU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 155Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiQ6IRU5
KOiK04645
OMAiTKAANRN
OrthoDBiEOG091G0WEF
PhylomeDBiQ6IRU5
TreeFamiTF313162

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IRU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DPGFGAPAAS
60 70 80 90 100
QVASAQPGLA SGAGSEDMST TVNGDVFQEA NGPADGYAAI AQADRLTQEP
110 120 130 140 150
ESIRKWREEQ KKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN
160 170 180 190 200
KINNRIADKA FYQQPDADTI GYVASEEAFV KESKEETPGT EWEKVAQLCD
210 220
FNPKSSKQCK DVSRLRSVLM SLKQTPLSR
Length:229
Mass (Da):25,172
Last modified:July 5, 2004 - v1
Checksum:i62C87F71DB9F782A
GO
Isoform 2 (identifier: Q6IRU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-173: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):23,174
Checksum:iDE25CC6106552C14
GO
Isoform 3 (identifier: Q6IRU5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-229: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):16,834
Checksum:i7A5CBD04ECF17B68
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BHJ0F7BHJ0_MOUSE
Clathrin light chain
Cltb
123Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013383156 – 229Missing in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_013382156 – 173Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009844 mRNA Translation: BAB26539.1
AK029382 mRNA Translation: BAC26430.1
AK045989 mRNA Translation: BAC32563.1
BC070404 mRNA Translation: AAH70404.1
CCDSiCCDS26533.1 [Q6IRU5-2]
CCDS84024.1 [Q6IRU5-1]
RefSeqiNP_001334441.1, NM_001347512.1 [Q6IRU5-1]
NP_083146.1, NM_028870.4 [Q6IRU5-2]
UniGeneiMm.290026

Genome annotation databases

EnsembliENSMUST00000049575; ENSMUSP00000053371; ENSMUSG00000047547 [Q6IRU5-1]
ENSMUST00000091609; ENSMUSP00000089198; ENSMUSG00000047547 [Q6IRU5-2]
GeneIDi74325
KEGGimmu:74325
UCSCiuc007qon.1 mouse [Q6IRU5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009844 mRNA Translation: BAB26539.1
AK029382 mRNA Translation: BAC26430.1
AK045989 mRNA Translation: BAC32563.1
BC070404 mRNA Translation: AAH70404.1
CCDSiCCDS26533.1 [Q6IRU5-2]
CCDS84024.1 [Q6IRU5-1]
RefSeqiNP_001334441.1, NM_001347512.1 [Q6IRU5-1]
NP_083146.1, NM_028870.4 [Q6IRU5-2]
UniGeneiMm.290026

3D structure databases

ProteinModelPortaliQ6IRU5
SMRiQ6IRU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216666, 1 interactor
IntActiQ6IRU5, 2 interactors

PTM databases

iPTMnetiQ6IRU5
PhosphoSitePlusiQ6IRU5
SwissPalmiQ6IRU5

2D gel databases

REPRODUCTION-2DPAGEiQ6IRU5

Proteomic databases

PeptideAtlasiQ6IRU5
PRIDEiQ6IRU5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049575; ENSMUSP00000053371; ENSMUSG00000047547 [Q6IRU5-1]
ENSMUST00000091609; ENSMUSP00000089198; ENSMUSG00000047547 [Q6IRU5-2]
GeneIDi74325
KEGGimmu:74325
UCSCiuc007qon.1 mouse [Q6IRU5-1]

Organism-specific databases

CTDi1212
MGIiMGI:1921575 Cltb

Phylogenomic databases

GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiQ6IRU5
KOiK04645
OMAiTKAANRN
OrthoDBiEOG091G0WEF
PhylomeDBiQ6IRU5
TreeFamiTF313162

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-5099900 WNT5A-dependent internalization of FZD4
R-MMU-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiCltb mouse
PROiPR:Q6IRU5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047547 Expressed in 279 organ(s), highest expression level in cerebellum
CleanExiMM_CLTB
ExpressionAtlasiQ6IRU5 baseline and differential
GenevisibleiQ6IRU5 MM

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLCB_MOUSE
AccessioniPrimary (citable) accession number: Q6IRU5
Secondary accession number(s): Q8BR04, Q8CDX9, Q9CV35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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