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Entry version 82 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Calmodulin-regulated spectrin-associated protein 1

Gene

camsap1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to camsap2 and camsap3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:camsap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-940444, camsap1.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003168311 – 1576Calmodulin-regulated spectrin-associated protein 1Add BLAST1576

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6IRN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini217 – 332Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST116
Domaini1437 – 1571CKKPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni415 – 447DisorderedSequence analysisAdd BLAST33
Regioni549 – 572DisorderedSequence analysisAdd BLAST24
Regioni595 – 653DisorderedSequence analysisAdd BLAST59
Regioni811 – 852DisorderedSequence analysisAdd BLAST42
Regioni1108 – 1149DisorderedSequence analysisAdd BLAST42
Regioni1178 – 1236DisorderedSequence analysisAdd BLAST59
Regioni1274 – 1422DisorderedSequence analysisAdd BLAST149

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili857 – 889Sequence analysisAdd BLAST33
Coiled coili992 – 1022Sequence analysisAdd BLAST31
Coiled coili1254 – 1315Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi550 – 569Polar residuesSequence analysisAdd BLAST20
Compositional biasi595 – 615Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi616 – 653Polar residuesSequence analysisAdd BLAST38
Compositional biasi811 – 827Polar residuesSequence analysisAdd BLAST17
Compositional biasi1130 – 1149Polar residuesSequence analysisAdd BLAST20
Compositional biasi1178 – 1192Polar residuesSequence analysisAdd BLAST15
Compositional biasi1193 – 1212Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1221 – 1236Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1274 – 1334Basic and acidic residuesSequence analysisAdd BLAST61
Compositional biasi1356 – 1391Polar residuesSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
741937at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940, CAMSAP
IPR031372, CAMSAP_CC1
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR038209, CKK_dom_sf
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21595, PTHR21595, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095, CAMSAP_CC1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF08683, CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051, CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF50346, SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS51508, CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6IRN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDIGLSASG DSTRRKMEAF ADCAVEVVPL DLYDSFRAKI AANLQWICAK
60 70 80 90 100
AYGIDNVPEE LKDPFYTDQY EQEHIKPPVI KLLLSSELYC RVCSLILKGD
110 120 130 140 150
QVAALQGHQP VIQALSRKGI YIMESDDAPV SESDLSCCPI KMSAHMSMID
160 170 180 190 200
ALMMAYTVEM ISIEKVVASV KRFSTFSASK ELPYDLEDAM VFWINKVNLK
210 220 230 240 250
MREILEREQR IKQQVIESPS HPKVRYRRDH PSSRHLPYFP ILEDLTKDIS
260 270 280 290 300
DGAALLAVIH FYCPEQMKLD DICLKEVTSM ADSVYNIQLL KEFSNEYLNK
310 320 330 340 350
CFYLTLEDML YTPLVLKPNI MVFIAELFWW FENVKPEFVH PRDTQELKEA
360 370 380 390 400
KIVMHPKTSR PQVPISNATK RSFLASPGST TDSQATAASE SCSSNYLQAE
410 420 430 440 450
DAENGKGCAV FSPSHPLLPL RQKQQKSVKP EESLNHRDQA NSLTRADGQP
460 470 480 490 500
MASIIAWKEK KPRPLSQTFA LHHAADDVES TSGDSISLAR SISKDSLASN
510 520 530 540 550
IVNPTPKHQS YPTPIKVLPK SLLGNVDIED DEEELVAFIR SDDASCPGDL
560 570 580 590 600
ELQSVSSRAS SQMSTSRLRR PADLESKPDS FFLEPLMPAV LKPAKEKHMV
610 620 630 640 650
PKSEEYGEGK QKGFSSKRQN EGNQSFSRKK IINNHTGHDL NRTFTPLSSL
660 670 680 690 700
ESDPLRTDPV QLSIESGNGN FRPLATSSVE SSEHGGGFFL HDLNADDDVE
710 720 730 740 750
DKPSAGNLIM EDPHKPDTTW TVLRPGSENL DVGGCEEVAV SRPVGKYIGE
760 770 780 790 800
EESVKLQEDL KLKEHDDKDD ASGRSSPCLS TISQISSASM ASGSMRMTSF
810 820 830 840 850
AERKFQKLNS YETKSSTSSS QKTTPDGSEC CPPPLTTWKQ RREQSPGRQN
860 870 880 890 900
RDHANVLASE LVQLHMQLEE KRRVIEAQKK KMESLSARQR LKLGKAAFLH
910 920 930 940 950
VVKKGKPETV AQPVKPEHGF RDYTKRTPED IDTVSVNAKV EQYLESIDPG
960 970 980 990 1000
IVSSEVQEAF TDPKLKDPAL LEADICNLMA DANPEDIDSE IDVNECDLSI
1010 1020 1030 1040 1050
EKLNETISTL QQAIMKISQQ QEMLMKAPSM AVPPLPSSSQ DHKLKPSVQF
1060 1070 1080 1090 1100
VEPISPPGMP IVRKTTRFGQ GRNARSLRVT EQKLAKEKMQ SSSRVITPTN
1110 1120 1130 1140 1150
SIETVPHLKS VQPLKSPSVP TEESPVEVVP EQGSASQDKP TTGGFRLHND
1160 1170 1180 1190 1200
NSQRTFVLST SKDANIISEQ MHREVISSSR VAGVSTSESS GKENVPVDER
1210 1220 1230 1240 1250
HKSSLIEVDL SDLKEPDEGE EESDHPEKTK DIISDDQKSG VGFFFKDEQK
1260 1270 1280 1290 1300
AEDELAKKRA AFLMKQQRKA EEARLRKRQL EAEVEQKRDD ARRKAEEDRI
1310 1320 1330 1340 1350
RKDEEKARRE LIKQEYLRRK QEQILEEQGL GRPKPKPKSK KTRPKSVHRE
1360 1370 1380 1390 1400
ESYSDSGTKY SSTPDNLSSA QSGSSLSLAS GATTEAESVH SGGTPSHRVD
1410 1420 1430 1440 1450
CVDAPSGMGR HQSRNAERDW ENASTASSIA SVAEYSGPKL YKEPSSKSNK
1460 1470 1480 1490 1500
PLIHNAISHC CLAGKVNEAI KNSTLDELEK CDSNHYIILF RDAGCQFRAL
1510 1520 1530 1540 1550
YSYYPETEEI CKLTGTGPKN ITKKMIDKLY KYSSDRKQFT VIPAKTMSAS
1560 1570
VDALTIHNHL WQAKRPALPK KNSLGK
Length:1,576
Mass (Da):175,934
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C22D339E783603E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC070721 mRNA Translation: AAH70721.1

NCBI Reference Sequences

More...
RefSeqi
NP_001084957.1, NM_001091488.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
432015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:432015

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070721 mRNA Translation: AAH70721.1
RefSeqiNP_001084957.1, NM_001091488.1

3D structure databases

SMRiQ6IRN6
ModBaseiSearch...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
432015

Genome annotation databases

GeneIDi432015
KEGGixla:432015

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
432015
XenbaseiXB-GENE-940444, camsap1.S

Phylogenomic databases

OrthoDBi741937at2759

Family and domain databases

Gene3Di1.10.418.10, 1 hit
3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940, CAMSAP
IPR031372, CAMSAP_CC1
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR038209, CKK_dom_sf
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf
PANTHERiPTHR21595, PTHR21595, 1 hit
PfamiView protein in Pfam
PF17095, CAMSAP_CC1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF08683, CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051, CAMSAP_CKK, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF50346, SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS51508, CKK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6IRN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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