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Protein

Carboxypeptidase Q

Gene

Cpq

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi290Zinc 1By similarity1
Metal bindingi302Zinc 1By similarity1
Metal bindingi302Zinc 2; catalyticBy similarity1
Active sitei336NucleophileBy similarity1
Metal bindingi337Zinc 2; catalyticBy similarity1
Metal bindingi364Zinc 1By similarity1
Metal bindingi434Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • peptide catabolic process Source: UniProtKB
  • proteolysis Source: UniProtKB
  • thyroid hormone generation Source: UniProtKB
  • tissue regeneration Source: RGD

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Q (EC:3.4.17.-)
Alternative name(s):
Hematopoietic lineage switch 2 related protein
Short name:
Hls2-rp
Liver annexin-like protein 1
Short name:
LAL-1
Plasma glutamate carboxypeptidase
Gene namesi
Name:Cpq
Synonyms:Pgcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628610 Cpq

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000031226421 – 44By similarityAdd BLAST24
ChainiPRO_000031226545 – 472Carboxypeptidase QAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains.1 Publication

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6IRK9
PRIDEiQ6IRK9

PTM databases

iPTMnetiQ6IRK9
PhosphoSitePlusiQ6IRK9

Expressioni

Inductioni

During regeneration of liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000005931 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ6IRK9 RN

Interactioni

Subunit structurei

Homodimer. The monomeric form is inactive while the homodimer is active (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6IRK9, 1 interactor
STRINGi10116.ENSRNOP00000008211

Structurei

3D structure databases

ProteinModelPortaliQ6IRK9
SMRiQ6IRK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00390000018110
HOGENOMiHOG000295607
HOVERGENiHBG105014
InParanoidiQ6IRK9
KOiK01302
OMAiFMNEENG
OrthoDBiEOG091G08CB
PhylomeDBiQ6IRK9
TreeFamiTF323248

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IRK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFLFFLFVA VVHLFSLGSG KAIYKSGVSQ RTFQEIKEEI ANYEDVAKAI
60 70 80 90 100
INLAVYGKYQ NRSYERLGLL VDTVGPRLSG SKNLEKAIQI MYQNLQQDGL
110 120 130 140 150
ENVHLEQVRI PHWERGEESA VMVVPRIHKL AILGLGGSIG TPPEGITAEV
160 170 180 190 200
LVVASFVELQ RRASEARGKI VVYNQPYTDY GKTVQYRERG AVEAAKVGAV
210 220 230 240 250
ASLIRSVASF SIYSPHTGHQ GYQDGVPKIP TACITIEDAE MMSRMASRGD
260 270 280 290 300
KIVIHLKMGA KTYPDTDSFN TVAEITGSKY PEEVVLVSGH LDSWDVGQGA
310 320 330 340 350
LDDGGGAFIS WEALSLVKDL GLRPKRTLRL VLWTAEEQGG VGASQYYELH
360 370 380 390 400
KANISKYSLV MEADSGTFLP TGLQFTGSDK ARAIMKEVMS LLQPLNITKV
410 420 430 440 450
FNDAEGTDIN FWIQAGVPGA SLRDDLYKYF FFHHSHGDTM TAMDPKQMNV
460 470
AAAVWAVVAY VVADMEEMLP RS
Length:472
Mass (Da):52,042
Last modified:July 5, 2004 - v1
Checksum:i1ABB7863A99CD8CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114E → G in AAC72384 (Ref. 2) Curated1
Sequence conflicti245M → T in AAF36518 (PubMed:12390252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131077 mRNA Translation: AAF36518.1
AF097723 mRNA Translation: AAC72384.1
BC070884 mRNA Translation: AAH70884.1
RefSeqiNP_113828.1, NM_031640.1
XP_008763639.1, XM_008765417.2
UniGeneiRn.17112

Genome annotation databases

EnsembliENSRNOT00000008211; ENSRNOP00000008211; ENSRNOG00000005931
GeneIDi58952
KEGGirno:58952
UCSCiRGD:628610 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131077 mRNA Translation: AAF36518.1
AF097723 mRNA Translation: AAC72384.1
BC070884 mRNA Translation: AAH70884.1
RefSeqiNP_113828.1, NM_031640.1
XP_008763639.1, XM_008765417.2
UniGeneiRn.17112

3D structure databases

ProteinModelPortaliQ6IRK9
SMRiQ6IRK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IRK9, 1 interactor
STRINGi10116.ENSRNOP00000008211

PTM databases

iPTMnetiQ6IRK9
PhosphoSitePlusiQ6IRK9

Proteomic databases

PaxDbiQ6IRK9
PRIDEiQ6IRK9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008211; ENSRNOP00000008211; ENSRNOG00000005931
GeneIDi58952
KEGGirno:58952
UCSCiRGD:628610 rat

Organism-specific databases

CTDi10404
RGDi628610 Cpq

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00390000018110
HOGENOMiHOG000295607
HOVERGENiHBG105014
InParanoidiQ6IRK9
KOiK01302
OMAiFMNEENG
OrthoDBiEOG091G08CB
PhylomeDBiQ6IRK9
TreeFamiTF323248

Miscellaneous databases

PROiPR:Q6IRK9

Gene expression databases

BgeeiENSRNOG00000005931 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ6IRK9 RN

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBPQ_RAT
AccessioniPrimary (citable) accession number: Q6IRK9
Secondary accession number(s): Q9JLV0, Q9Z1Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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