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Protein

Centrosomal protein of 70 kDa

Gene

Cep70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 70 kDa
Short name:
Cep70
Gene namesi
Name:Cep70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915371 Cep70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894981 – 616Centrosomal protein of 70 kDaAdd BLAST616

Proteomic databases

PaxDbiQ6IQY5
PRIDEiQ6IQY5

PTM databases

iPTMnetiQ6IQY5
PhosphoSitePlusiQ6IQY5

Expressioni

Gene expression databases

BgeeiENSMUSG00000056267 Expressed in 251 organ(s), highest expression level in embryo
CleanExiMM_CEP70
ExpressionAtlasiQ6IQY5 baseline and differential
GenevisibleiQ6IQY5 MM

Interactioni

Subunit structurei

Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091312

Structurei

3D structure databases

ProteinModelPortaliQ6IQY5
SMRiQ6IQY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati502 – 535TPRAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 210Sequence analysisAdd BLAST115
Coiled coili273 – 335Sequence analysisAdd BLAST63

Domaini

The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.By similarity

Keywords - Domaini

Coiled coil, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFWI Eukaryota
ENOG4111V7R LUCA
GeneTreeiENSGT00390000009029
HOGENOMiHOG000290163
HOVERGENiHBG050899
InParanoidiQ6IQY5
KOiK16802
OMAiIYPRMNE
OrthoDBiEOG091G08G2
PhylomeDBiQ6IQY5
TreeFamiTF330986

Family and domain databases

InterProiView protein in InterPro
IPR037692 CEP70
IPR019734 TPR_repeat
PANTHERiPTHR14594 PTHR14594, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6IQY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEGSQIFLL PISTSDSTKE PLSPVASKAQ DPSLLSNRLM IEKQQEEAEW
60 70 80 90 100
ESINGLLMTH GFKPLCLVKG ADLRDFIVFD KQSSQKMRQI LKTLMEETTR
110 120 130 140 150
QQSMIRELIE TNQQLKSELQ LEQNRAAHQE QRANDLQQIM DSVKSKIGEL
160 170 180 190 200
EDESLNRVCQ QQNRIKDLQK EYKMLQMKCQ QYKKNRMEQE GTIASLQKEI
210 220 230 240 250
HRLAKEEEER ILTQNRVFAH LCRRVPHSVL DKQLLCLIDY YECKLRKLHI
260 270 280 290 300
QRQFEEDSQS EEKDFTNLGA SPNYKGVLMS LQKQLKESKS RIDVLVGEKL
310 320 330 340 350
SLQKDLENRP TEHELRLYKQ QVKKLEKTLK KNIKLQDLIG QKKSDDTEKK
360 370 380 390 400
DEPSKDSHQQ ALIEQSYFQV LCSINSIVHN PRAPVIIYKQ SKGRAPNGNK
410 420 430 440 450
DIGQDCGFEH LVPIIEMWVD ELTSLKDLYK SLKILSAELV PWHSLKKLDE
460 470 480 490 500
KEGVKVGDLL FMVDTMLEEV ENQKETSSTP NSQTLQAIVS HFQKLFDVQS
510 520 530 540 550
LNGVFPRMNE VYTRLGEMNN AVRNLQELLE LDSSSSLCVV VSTVGKLCEI
560 570 580 590 600
INKDVSEQVK QVLGPEDLQS IIKKLEEHEE FFPAFQAFAN DLLEILEIDD
610
LDAIVPAVKK LKILSY
Length:616
Mass (Da):71,065
Last modified:July 5, 2004 - v1
Checksum:i57302F6297E3ECBF
GO
Isoform 2 (identifier: Q6IQY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-578: SIIKKLEEH → RYLLEMHLE
     579-616: Missing.

Note: No experimental confirmation available.
Show »
Length:578
Mass (Da):66,850
Checksum:i4F7BB4987D6E9395
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J2B4A0A0R4J2B4_MOUSE
Centrosomal protein of 70 kDa
Cep70
160Annotation score:
A0A087WQX1A0A087WQX1_MOUSE
Centrosomal protein of 70 kDa
Cep70
179Annotation score:
A0A087WPS5A0A087WPS5_MOUSE
Centrosomal protein of 70 kDa
Cep70
116Annotation score:
A0A087WSG9A0A087WSG9_MOUSE
Centrosomal protein of 70 kDa
Cep70
72Annotation score:

Sequence cautioni

The sequence AAF97768 differs from that shown. Reason: Frameshift at position 614.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18T → I in BAE21486 (PubMed:16141072).Curated1
Sequence conflicti213T → L in AAF97768 (Ref. 1) Curated1
Sequence conflicti244K → Q in AAF97768 (Ref. 1) Curated1
Sequence conflicti286K → R in AAF97768 (Ref. 1) Curated1
Sequence conflicti335L → F in AAF97768 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042142570 – 578SIIKKLEEH → RYLLEMHLE in isoform 2. 1 Publication9
Alternative sequenceiVSP_042143579 – 616Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242319 mRNA Translation: AAF97768.1 Frameshift.
AK020174 mRNA Translation: BAB32020.1
AK020622 mRNA Translation: BAB32153.1
AK133048 mRNA Translation: BAE21486.1
BC050819 mRNA Translation: AAH50819.1
BC071260 mRNA Translation: AAH71260.1
CCDSiCCDS40738.1 [Q6IQY5-1]
RefSeqiNP_076362.2, NM_023873.3 [Q6IQY5-1]
XP_006511449.1, XM_006511386.3 [Q6IQY5-1]
XP_011241104.1, XM_011242802.2 [Q6IQY5-1]
UniGeneiMm.288739

Genome annotation databases

EnsembliENSMUST00000093795; ENSMUSP00000091312; ENSMUSG00000056267 [Q6IQY5-1]
ENSMUST00000191335; ENSMUSP00000139816; ENSMUSG00000056267 [Q6IQY5-2]
GeneIDi68121
KEGGimmu:68121
UCSCiuc009rdy.1 mouse [Q6IQY5-2]
uc009rdz.1 mouse [Q6IQY5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242319 mRNA Translation: AAF97768.1 Frameshift.
AK020174 mRNA Translation: BAB32020.1
AK020622 mRNA Translation: BAB32153.1
AK133048 mRNA Translation: BAE21486.1
BC050819 mRNA Translation: AAH50819.1
BC071260 mRNA Translation: AAH71260.1
CCDSiCCDS40738.1 [Q6IQY5-1]
RefSeqiNP_076362.2, NM_023873.3 [Q6IQY5-1]
XP_006511449.1, XM_006511386.3 [Q6IQY5-1]
XP_011241104.1, XM_011242802.2 [Q6IQY5-1]
UniGeneiMm.288739

3D structure databases

ProteinModelPortaliQ6IQY5
SMRiQ6IQY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091312

PTM databases

iPTMnetiQ6IQY5
PhosphoSitePlusiQ6IQY5

Proteomic databases

PaxDbiQ6IQY5
PRIDEiQ6IQY5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093795; ENSMUSP00000091312; ENSMUSG00000056267 [Q6IQY5-1]
ENSMUST00000191335; ENSMUSP00000139816; ENSMUSG00000056267 [Q6IQY5-2]
GeneIDi68121
KEGGimmu:68121
UCSCiuc009rdy.1 mouse [Q6IQY5-2]
uc009rdz.1 mouse [Q6IQY5-1]

Organism-specific databases

CTDi80321
MGIiMGI:1915371 Cep70

Phylogenomic databases

eggNOGiENOG410IFWI Eukaryota
ENOG4111V7R LUCA
GeneTreeiENSGT00390000009029
HOGENOMiHOG000290163
HOVERGENiHBG050899
InParanoidiQ6IQY5
KOiK16802
OMAiIYPRMNE
OrthoDBiEOG091G08G2
PhylomeDBiQ6IQY5
TreeFamiTF330986

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiCep70 mouse
PROiPR:Q6IQY5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056267 Expressed in 251 organ(s), highest expression level in embryo
CleanExiMM_CEP70
ExpressionAtlasiQ6IQY5 baseline and differential
GenevisibleiQ6IQY5 MM

Family and domain databases

InterProiView protein in InterPro
IPR037692 CEP70
IPR019734 TPR_repeat
PANTHERiPTHR14594 PTHR14594, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEP70_MOUSE
AccessioniPrimary (citable) accession number: Q6IQY5
Secondary accession number(s): Q3V0L8
, Q9CRL9, Q9CTS4, Q9JIC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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