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Protein

Zinc finger protein 219

Gene

Znf219

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (PubMed:20940257). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:20940257). Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity). Regulates SNCA expression in primary cortical neurons (By similarity). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (PubMed:20940257). Plays a role in chondrocyte differentiation (PubMed:20940257).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 83C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri89 – 111C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri193 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 9Sequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2191 Publication
Gene namesi
Name:Znf2191 Publication
Synonyms:Zfp219Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1917140 Zfp219

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004425371 – 726Zinc finger protein 219Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei699PhosphothreonineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6IQX8
PaxDbiQ6IQX8
PeptideAtlasiQ6IQX8
PRIDEiQ6IQX8

Expressioni

Tissue specificityi

Highly expressed in primary chondrocytes, heart, pancreas and testis.1 Publication

Developmental stagei

Expressed in proliferating chondrocytes in the tibia at embryonic stage E15.5 (at protein level). Expressed in limb buds at stage E11.5, where it colocalizes with Col2a1 and Sox9.1 Publication

Gene expression databases

BgeeiENSMUSG00000049295 Expressed in 313 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ6IQX8 baseline and differential
GenevisibleiQ924S6 MM

Interactioni

Subunit structurei

Interacts with SOX9 (via C-terminus).1 Publication

Protein-protein interaction databases

IntActiQ6IQX8, 10 interactors
MINTiQ6IQX8
STRINGi10090.ENSMUSP00000068184

Structurei

3D structure databases

ProteinModelPortaliQ6IQX8
SMRiQ6IQX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi229 – 275Pro-richPROSITE-ProRule annotationAdd BLAST47

Domaini

C2H2-type zinc-finger domains 5 and 6 are important for the interaction with SOX9.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 83C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri89 – 111C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri193 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 9Sequence analysisAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000140857
HOVERGENiHBG054187
InParanoidiQ6IQX8
OMAiASPPYAR
OrthoDBiEOG091G05JC
PhylomeDBiQ6IQX8
TreeFamiTF332241

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q6IQX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGSRPRILV GHLEPSPPAF DGELDLQRYS NGPGVSGTPG PGSPGMGAVG
60 70 80 90 100
WSETRAGERR FPCPVCGKRF RFNSILALHL RAHPGAQAFQ CPHCGHRAAQ
110 120 130 140 150
RALLRSHLRT HQPERPRSPA ARLLLELEER ALLREARLGR ARSSGGMQSS
160 170 180 190 200
PAAEGLARPQ VPSSSAFRCP FCKGKFRTSA ERERHLHILH RPWKCSLCSF
210 220 230 240 250
GSSQEEELLH HSLTAHGASE RPLAATSTPE PPPPPQQEPR SALEPEPEPE
260 270 280 290 300
PRPEPDREAN PAPTPAPPEE PPAPPEFRCQ VCGQSFTQSW FLKGHMRKHK
310 320 330 340 350
ASFDHACPVC GRCFKEPWFL KNHMKVHTSK LGPLRAPGPG SAPARAPQPP
360 370 380 390 400
DLSLLAYEPL GPALLLAPAP APAERREPPS LLGYLSVRAG EVRPNGEGAD
410 420 430 440 450
PGGGRSYGGF RPLPSALPNR ARRHRTEEPE EEEEVVEAEE ESWARGRSLG
460 470 480 490 500
SLTSLHPNPG EGSGQPAPAA GTQARSTATQ EENGLLVGGT RSEAGRGATG
510 520 530 540 550
KDCPFCGKSF RSAHHLKVHL RVHTGERPYK CPHCDYAGTQ SGSLKYHLQR
560 570 580 590 600
HHREQRSSAG PGPPPEPPPP SQRGSLQPQS GAKPTQASAT WVEGTASTRP
610 620 630 640 650
PSSSTGPGSR RKPASPGRTL RNGRGGEAEP LDLSLRAGPG GEAGAGGALH
660 670 680 690 700
RCLFCPFATG APELMALHLQ VHHSRRARGR RQPRADTSPT YVRAPSGETP
710 720
PSPPLEEEGS PGLSRSGEAG LGGQER
Length:726
Mass (Da):77,796
Last modified:July 5, 2004 - v1
Checksum:i7F0E43159B73B0F4
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VA98Q4VA98_MOUSE
Zfp219 protein
Zfp219 mCG_18709
681Annotation score:
A0A2I3BQZ2A0A2I3BQZ2_MOUSE
Zinc finger protein 219
Zfp219
109Annotation score:
A0A2I3BQI8A0A2I3BQI8_MOUSE
Zinc finger protein 219
Zfp219
131Annotation score:
A0A2I3BS40A0A2I3BS40_MOUSE
Zinc finger protein 219
Zfp219
141Annotation score:
A0A2I3BR43A0A2I3BR43_MOUSE
Zinc finger protein 219
Zfp219
201Annotation score:
A0A2I3BPD9A0A2I3BPD9_MOUSE
Zinc finger protein 219
Zfp219
95Annotation score:
A0A2I3BS09A0A2I3BS09_MOUSE
Zinc finger protein 219
Zfp219
14Annotation score:
A0A2I3BQ96A0A2I3BQ96_MOUSE
Zinc finger protein 219
Zfp219
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48A → Q in BAB61057 (PubMed:16141072).Curated1
Sequence conflicti274P → T in BAB61057 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008516 mRNA Translation: BAB25714.1
AB063578 mRNA Translation: BAB61057.1
AC157572 Genomic DNA No translation available.
CH466659 Genomic DNA Translation: EDL42263.1
CH466659 Genomic DNA Translation: EDL42264.1
CH466659 Genomic DNA Translation: EDL42265.1
BC010447 mRNA Translation: AAH10447.1
BC071271 mRNA Translation: AAH71271.1
CCDSiCCDS36916.1
RefSeqiNP_001240623.1, NM_001253694.1
NP_001240624.1, NM_001253695.1
NP_081524.2, NM_027248.2
XP_006519561.1, XM_006519498.3
XP_006519562.1, XM_006519499.3
XP_006519564.1, XM_006519501.3
XP_006519565.1, XM_006519502.3
XP_006519566.1, XM_006519503.2
XP_006519567.1, XM_006519504.3
XP_006519568.1, XM_006519505.1
XP_011243478.1, XM_011245176.2
XP_011243479.1, XM_011245177.1
XP_017171669.1, XM_017316180.1
UniGeneiMm.475652

Genome annotation databases

EnsembliENSMUST00000067549; ENSMUSP00000068184; ENSMUSG00000049295
ENSMUST00000166169; ENSMUSP00000126854; ENSMUSG00000049295
ENSMUST00000226522; ENSMUSP00000154709; ENSMUSG00000049295
GeneIDi69890
KEGGimmu:69890
UCSCiuc007tnv.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008516 mRNA Translation: BAB25714.1
AB063578 mRNA Translation: BAB61057.1
AC157572 Genomic DNA No translation available.
CH466659 Genomic DNA Translation: EDL42263.1
CH466659 Genomic DNA Translation: EDL42264.1
CH466659 Genomic DNA Translation: EDL42265.1
BC010447 mRNA Translation: AAH10447.1
BC071271 mRNA Translation: AAH71271.1
CCDSiCCDS36916.1
RefSeqiNP_001240623.1, NM_001253694.1
NP_001240624.1, NM_001253695.1
NP_081524.2, NM_027248.2
XP_006519561.1, XM_006519498.3
XP_006519562.1, XM_006519499.3
XP_006519564.1, XM_006519501.3
XP_006519565.1, XM_006519502.3
XP_006519566.1, XM_006519503.2
XP_006519567.1, XM_006519504.3
XP_006519568.1, XM_006519505.1
XP_011243478.1, XM_011245176.2
XP_011243479.1, XM_011245177.1
XP_017171669.1, XM_017316180.1
UniGeneiMm.475652

3D structure databases

ProteinModelPortaliQ6IQX8
SMRiQ6IQX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IQX8, 10 interactors
MINTiQ6IQX8
STRINGi10090.ENSMUSP00000068184

Proteomic databases

MaxQBiQ6IQX8
PaxDbiQ6IQX8
PeptideAtlasiQ6IQX8
PRIDEiQ6IQX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067549; ENSMUSP00000068184; ENSMUSG00000049295
ENSMUST00000166169; ENSMUSP00000126854; ENSMUSG00000049295
ENSMUST00000226522; ENSMUSP00000154709; ENSMUSG00000049295
GeneIDi69890
KEGGimmu:69890
UCSCiuc007tnv.3 mouse

Organism-specific databases

CTDi69890
MGIiMGI:1917140 Zfp219

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000140857
HOVERGENiHBG054187
InParanoidiQ6IQX8
OMAiASPPYAR
OrthoDBiEOG091G05JC
PhylomeDBiQ6IQX8
TreeFamiTF332241

Miscellaneous databases

ChiTaRSiZfp219 mouse
PROiPR:Q6IQX8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049295 Expressed in 313 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ6IQX8 baseline and differential
GenevisibleiQ924S6 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN219_MOUSE
AccessioniPrimary (citable) accession number: Q6IQX8
Secondary accession number(s): Q921W9, Q924S6, Q9CVF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2017
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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